Peptides Neutralizing Lipopolysaccharide - Structure and Function

Title: Peptides Neutralizing Lipopolysaccharide - Structure and Function

Volume: 1 Issue: 4

Author(s): P. Pristovsek and J. Kidric

Affiliation:

Keywords: Lipopolysaccharide, Lipopeptides Polymyxin, Lactoferrin Lactoferricin, Polymyxin B

Abstract: Lipopolysaccharide (LPS) induced Gram-negative sepsis and septic shock remain lethal in up to 60 percent of cases, and LPS antagonists that neutralize its endotoxic action are the subject of intensive research. In the last decade peptidic antagonists have become increasingly important in providing leads for treatment of LPS-mediated diseases. In this review an overview of the sources, functions and structures of antiseptic and antibacterial peptides that interact with LPS is presented.

Cite this article as:

Pristovsek P. and Kidric J., Peptides Neutralizing Lipopolysaccharide - Structure and Function, Mini-Reviews in Medicinal Chemistry 2001; 1 (4) . https://dx.doi.org/10.2174/1389557013406729