Design of Dermaseptin S3 Analogues having Bacterial Cell Selectivity without Mammalian Cell Toxicity

Title: Design of Dermaseptin S3 Analogues having Bacterial Cell Selectivity without Mammalian Cell Toxicity

Volume: 8 Issue: 4

Author(s): Song Yub Shin, Sung Tae Yang, Soo Hyum Eom, Woo Keun Song, Yangmee Kim, Kyung-Soo Hahm and Jae Il Kim

Affiliation:

Keywords: DERMASEPTIN S3 ANALOGUES, MAMMALIAN CELL TOXICITY, helical antimicrobial peptide, Phyllomedusa sauvagii, antibacterial activity, Hemolytic activity

Abstract: Dermaseptin S3 (DS3) is a a-helical antimicrobial peptide isolated from the South American frogs Phyllomedusa sauvagii. Insertion of Gly-Pro sequence into DS3 resulted in a drastic reduction in the mammalian cell toxicity against human red blood and normal fibroblast cells, with retention of the antibacterial activity. The results indicated that the bend created by insertion of Gly-Pro in the continuous a-helical peptide plays an important role in providing high selectivity against bacterial cells without mammalian cell toxicity.

Cite this article as:

Shin Yub Song, Yang Tae Sung, Eom Hyum Soo, Song Keun Woo, Kim Yangmee, Hahm Kyung-Soo and Kim Il Jae, Design of Dermaseptin S3 Analogues having Bacterial Cell Selectivity without Mammalian Cell Toxicity, Protein & Peptide Letters 2001; 8 (4) . https://dx.doi.org/10.2174/0929866013409328

DOI https://dx.doi.org/10.2174/0929866013409328	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305