Natural Products as Trypanocidal, Antileishmanial and Antimalarial Drugs

Alain      Fournet; Victoria      Munoz

doi:10.2174/1568026023393011

Abstract

Parasitic diseases caused by protozoa as Leishmania, Trypanosome or Plasmodium are responsible for more than three millions deaths annually throughout the developing countries. This review covers recent studies on plant-secondary metabolites isolated from medicinal plants and that have demonstrated moderate to high activity in in vitro and in vivo bioassays against these protozoa. The biological activity of the last promising antiparasitic leads are described.

Keywords: antileishmanial and antimalarial drugs, trypanocidal drugs

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Current Topics in Medicinal Chemistry

Title: Natural Products as Trypanocidal, Antileishmanial and Antimalarial Drugs

Volume: 2 Issue: 11

Author(s): Alain Fournet and Victoria Munoz

Affiliation:

Keywords: antileishmanial and antimalarial drugs, trypanocidal drugs

Abstract: Parasitic diseases caused by protozoa as Leishmania, Trypanosome or Plasmodium are responsible for more than three millions deaths annually throughout the developing countries. This review covers recent studies on plant-secondary metabolites isolated from medicinal plants and that have demonstrated moderate to high activity in in vitro and in vivo bioassays against these protozoa. The biological activity of the last promising antiparasitic leads are described.

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Fournet Alain and Munoz Victoria, Natural Products as Trypanocidal, Antileishmanial and Antimalarial Drugs, Current Topics in Medicinal Chemistry 2002; 2 (11) . https://dx.doi.org/10.2174/1568026023393011