Chemotherapy of Chagas Disease: Status and New Developments

Hugo      Cerecetto; Mercedes      Gonzalez

doi:10.2174/1568026023393066

Abstract

Chagas disease is a major parasitic problem in developing countries in Central and South America. Chemotherapy for such disease is still insufficient and not effective in its chronic part. Many efforts have been made in recent years to know more about possible new biochemical targets to design new selective drugs. This paper reviews old therapeutic approaches -Nifurtimox, Benznidazole and related compounds- and the latest rationally developed drugs that prove to be active against different parasitic forms

Keywords: chemotherapy of chagas disease

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Current Topics in Medicinal Chemistry

Title: Chemotherapy of Chagas Disease: Status and New Developments

Volume: 2 Issue: 11

Author(s): Hugo Cerecetto and Mercedes Gonzalez

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Keywords: chemotherapy of chagas disease

Abstract: Chagas disease is a major parasitic problem in developing countries in Central and South America. Chemotherapy for such disease is still insufficient and not effective in its chronic part. Many efforts have been made in recent years to know more about possible new biochemical targets to design new selective drugs. This paper reviews old therapeutic approaches -Nifurtimox, Benznidazole and related compounds- and the latest rationally developed drugs that prove to be active against different parasitic forms

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Cerecetto Hugo and Gonzalez Mercedes, Chemotherapy of Chagas Disease: Status and New Developments, Current Topics in Medicinal Chemistry 2002; 2 (11) . https://dx.doi.org/10.2174/1568026023393066