Approaches for the Inhibition of Human Telomerase Based on the Use of Peptide Nucleic Acids and Hammerhead Ribozymes

Title: Approaches for the Inhibition of Human Telomerase Based on the Use of Peptide Nucleic Acids and Hammerhead Ribozymes

Volume: 3 Issue: 1

Author(s): N. Zaffaroni, R. Villa, M. Pennati and M. Folini

Affiliation:

Keywords: telomerase inhibitor, human telomerase, hammerhead ribozyme, peptide nucleic acid, htr

Abstract: The ability of peptide nucleic acids and hammerhead ribozymes, which target different subunits of human telomerase, to efficiently inhibit the enzymes catalytic activity has been clearly demonstrated in several in vitro studies carried out in human immortalized and cancer cell lines. However, the actual efficacy of these molecules still needs to be validated in in vivo human tumor models, and such validation appears to be largely dependent on the development of reliable systems for their intracellular delivery.

Cite this article as:

Zaffaroni N., Villa R., Pennati M. and Folini M., Approaches for the Inhibition of Human Telomerase Based on the Use of Peptide Nucleic Acids and Hammerhead Ribozymes, Mini-Reviews in Medicinal Chemistry 2003; 3 (1) . https://dx.doi.org/10.2174/1389557033405458