DNA Topoisomerases as Targets for Antiprotozoal Therapy

Title: DNA Topoisomerases as Targets for Antiprotozoal Therapy

Volume: 3 Issue: 6

Author(s): R. P. Bakshi and T. A. Shapiro

Affiliation:

Keywords: dna topoisomerase, antiparasitic, poison, inhibitor, trypanosoma, plasmodium, leishmania, protozoa

Abstract: Diseases caused by parasitic protozoa present a health problem of immense magnitude, and there is an urgent need for safe and effective new therapies. DNA topoisomerases are clinically relevant targets for anticancer and anti-bacterial agents. Inhibitor studies on parasite topoisomerases have revealed that these enzymes have great promise as molecular targets for anti-parasitics, and have helped to dissect the basic biology of DNA topoisomerases in these organisms. This review provides a brief introduction to DNA topoisomerases and anti-topoisomerase drugs, and an overview of studies on protozoal DNA topoisomerases and their inhibitors.

Cite this article as:

Bakshi P. R. and Shapiro A. T., DNA Topoisomerases as Targets for Antiprotozoal Therapy, Mini-Reviews in Medicinal Chemistry 2003; 3 (6) . https://dx.doi.org/10.2174/1389557033487863