Cysteine Protease Inhibitors Containing Small Rings

Title: Cysteine Protease Inhibitors Containing Small Rings

Volume: 3 Issue: 6

Author(s): T. Schirmeister and A. Klockow

Affiliation:

Keywords: cysteine protease inhibitors, epoxysuccinyl peptides, peptidomimetic inhibitors, epoxide, aziridine, thiirane, cyclopropane

Abstract: Since the discovery of E-64 in 1978 as potent cysteine protease inhibitor a variety of inhibitors containing small rings as electrophilic building blocks responsible for enzyme inhibition have been developed. In this review we summarize new aspects concerning epoxysuccinyl peptides derived from E-64 and discuss inhibition potency, selectivity and mechanisms of peptidic and peptidomimetic inhibitors containing epoxide, aziridine, thiirane, cyclopropane, ß-lactam and ß-lactone rings as electrophilic fragments.

Cite this article as:

Schirmeister T. and Klockow A., Cysteine Protease Inhibitors Containing Small Rings, Mini-Reviews in Medicinal Chemistry 2003; 3 (6) . https://dx.doi.org/10.2174/1389557033487935