Plant-Derived Triterpenoids as Potential Antineoplastic Agents

Title: Plant-Derived Triterpenoids as Potential Antineoplastic Agents

Volume: 3 Issue: 6

Author(s): W. N. Setzer and M. C. Setzer

Affiliation:

Keywords: triterpenoids, cytotoxic, antineoplastic, cancer

Abstract: Man has relied on plants as a source of medicinal agents for centuries. Today, with the specter of antibiotic resistance, emerging infectious diseases, and cancers, phytochemicals continue to provide new structural leads for the chemotherapeutic industry. A number of triterpenoids have shown promise as antineoplastic agents. Members of the cycloartane, lupane, ursane, oleanane, friedelane (especially quinone methides), dammarane, cucurbitacin, and limonoid triterpenoids, have demonstrated anti-proliferative activity on various cancer cell lines. This review covers the recent developments regarding antineoplastic / cytotoxic triterpenoids, excluding saponins, from higher plants.

Cite this article as:

Setzer N. W. and Setzer C. M., Plant-Derived Triterpenoids as Potential Antineoplastic Agents, Mini-Reviews in Medicinal Chemistry 2003; 3 (6) . https://dx.doi.org/10.2174/1389557033487854