Syntheses and Biological Activities of Iminosugars as α-L-Fucosidase Inhibitors

Title: Syntheses and Biological Activities of Iminosugars as α-L-Fucosidase Inhibitors

Volume: 8 Issue: 1

Author(s): Elena Moreno-Clavijo, Ana T. Carmona, Antonio J. Moreno-Vargas, Lidia Molina and Inmaculada Robina

Affiliation:

Keywords: Azafagomines, hydroxylated azepanes, piperidines, pyrrolidines, fucosidase inhibitors, iminosugars, azasugars, L-Fucosidase Inhibitors, glycosylation, glycosylation reactions, hydrolysis, glycoconjugates, carcinomas, L-fucosidases, Thermotoga maritima, Thermotoga maritima enzyme, iminocyclitols, hydrophobic, POLYHYDROXYLATED PYRROLIDINES, meso-pyrrolidine 1, human placenta, chromatography, Holzapfel, Crous method, Oxime, Bayon's method, pyrrolidinethylphosphonate, nitrone, Cope-House cyclization, tetraacetate, POLYHYDROXYLATED PIPERIDINES, POLYHYDROXYHEXAHYDROPYRIDAZINES, POLYHYDROXYAZEPANES

Abstract: A review dealing with iminosugars as inhibitors of α-L-fucosidases is presented. The different synthetic approaches for the preparation of the most relevant ones as well as their inhibitory properties are presented.

Cite this article as:

Moreno-Clavijo Elena, T. Carmona Ana, J. Moreno-Vargas Antonio, Molina Lidia and Robina Inmaculada, Syntheses and Biological Activities of Iminosugars as α-L-Fucosidase Inhibitors, Current Organic Synthesis 2011; 8 (1) . https://dx.doi.org/10.2174/157017911794407700