Mixed Connective Tissue Disease (MCTD) and Undifferentiated Connective Tissue Disease (UCTD)

Title: Mixed Connective Tissue Disease (MCTD) and Undifferentiated Connective Tissue Disease (UCTD)

Volume: 2 Issue: 3

Author(s): Yolanda Farhey and Evelyn V. Hess

Affiliation:

Keywords: MCTD, U1RNP, Raynaud's, overlapping syndromes, UCTD

Abstract: In Mixed Connective Tissue Disease (MCTD), features of various connective tissue disorders such as systemic lupus erythematosus (SLE), systemic sclerosis (PSSc), dermatomyositis/polymyositis (DM/PM), and occasionally Sjogrens syndrome and rheumatoid arthritis (RA) can coexist and overlap. The picture is marked by the presence of high titer anti-U1 ribonucleoprotein (RNP) antibodies. Over the last 30 years since first described a lot of controversial studies have been published regarding the nature, the severity or the very existence of the condition. We review here the various aspects and the characteristics which make it a distinctive autoimmune condition. We discuss the new understanding of the prognosis of this connective tissue disorder. We give an update on the management of MCTD. Some aspects of the Undifferentiated Connective Tissue Disease (UCTD) are approached as a class apart.

Cite this article as:

Farhey Yolanda and Hess V. Evelyn, Mixed Connective Tissue Disease (MCTD) and Undifferentiated Connective Tissue Disease (UCTD), Current Rheumatology Reviews 2006; 2 (3) . https://dx.doi.org/10.2174/157339706778019610

DOI https://dx.doi.org/10.2174/157339706778019610	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360