FeCl3 and FeCl3-SiO2 Catalysed Selective p-Methoxybenzylation of Alcohols with p-Methoxybenzyl Alcohol (PMB-OH)&#

Palakodety   Radha   Krishna; B.      Lavanya; A.   K.   Mahalingam; V.V.   Ramana   Reddy; G.   V.M.   Sharma

doi:10.2174/1570178054038939

Abstract

Anhydrous FeCl3 and FeCl3-SiO2 serve as Lewis acids for direct conversion of alcohols into pmethoxybezyl ethers using PMB-OH in good yields, the latter reagent was found to be effective in not only converting primary, allylic and propargylic alcohols selectively but also the pre-existing acid sensitive groups remained unscathed.

Keywords: deprotection, benzyl ethers, p-methoxybenzyl (pmb), catalytic ddq, nucleophilic attack, lewis acid, pmb alcohol

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Letters in Organic Chemistry

Title: FeCl3 and FeCl3-SiO2 Catalysed Selective p-Methoxybenzylation of Alcohols with p-Methoxybenzyl Alcohol (PMB-OH)&#

Volume: 2 Issue: 4

Author(s): Palakodety Radha Krishna, B. Lavanya, A. K. Mahalingam, V.V. Ramana Reddy and G. V.M. Sharma

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Keywords: deprotection, benzyl ethers, p-methoxybenzyl (pmb), catalytic ddq, nucleophilic attack, lewis acid, pmb alcohol

Abstract: Anhydrous FeCl3 and FeCl3-SiO2 serve as Lewis acids for direct conversion of alcohols into pmethoxybezyl ethers using PMB-OH in good yields, the latter reagent was found to be effective in not only converting primary, allylic and propargylic alcohols selectively but also the pre-existing acid sensitive groups remained unscathed.

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Krishna Radha Palakodety, Lavanya B., Mahalingam K. A., Reddy Ramana V.V. and Sharma V.M. G., FeCl3 and FeCl3-SiO2 Catalysed Selective p-Methoxybenzylation of Alcohols with p-Methoxybenzyl Alcohol (PMB-OH)&#, Letters in Organic Chemistry 2005; 2 (4) . https://dx.doi.org/10.2174/1570178054038939