Inhibition of Human Melanoma Cell Replication Using Protein Transduction Technology with a Uracil-DNA Glycosylase Inhibitor

Title: Inhibition of Human Melanoma Cell Replication Using Protein Transduction Technology with a Uracil-DNA Glycosylase Inhibitor

Volume: 2 Issue: 2

Author(s): Maria E. Ariza, Irene Pedersen and M. V. Williams

Affiliation:

Keywords: uracil-dna glycosylase, uracil-dna glycosylase inhibitor, protein transduction, melanoma

Abstract: We demonstrated that the uracil-DNA glycosylase inhibitor, when delivered to human melanoma cells using protein transduction technology, resulted in a dose and time dependent inhibition of uracil-DNA glycosylase (UNG) and this inhibited cell proliferation. These results suggest that a novel class of inhibitors specifically targeting UNG can be developed as potential anti-cancer agents.

Cite this article as:

Ariza E. Maria, Pedersen Irene and Williams V. M., Inhibition of Human Melanoma Cell Replication Using Protein Transduction Technology with a Uracil-DNA Glycosylase Inhibitor, Letters in Drug Design & Discovery 2005; 2 (2) . https://dx.doi.org/10.2174/1570180053175179

DOI https://dx.doi.org/10.2174/1570180053175179	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X