QSAR of the Anticonvulsant Enaminones; Molecular Modeling Aspects and other Assessments

Title: QSAR of the Anticonvulsant Enaminones; Molecular Modeling Aspects and other Assessments

Volume: 1 Issue: 4

Author(s): T. L. Wilson, P. L. Jackson, C. D. Hanson, Z. Xue, N. D. Eddington and K. R. Scott

Affiliation:

Keywords: epilepsy, sodium channel, anticonvulsants, molecular modeling, regression analysis

Abstract: The enaminones represent potentially useful agents for the clinical treatment in generalized tonic-clonic seizures (Epilepsia, 1993, 34(6), 1141-1145, Biopharm. Drug Disp. 2003, 397-407). A regression analysis was performed to provide a quantitative structure-activity relationship (QSAR) correlation model for prediction of activity for the anticonvulsant enaminones. Molecular modeling was performed to determine the molecular confluence of the Unverferth model (J. Med. Chem. 1998, 41, 63-73) to the enaminones. Conclusions related to the sodium channel model were assessed.

Cite this article as:

Wilson L. T., Jackson L. P., Hanson D. C., Xue Z., Eddington D. N. and Scott R. K., QSAR of the Anticonvulsant Enaminones; Molecular Modeling Aspects and other Assessments, Medicinal Chemistry 2005; 1 (4) . https://dx.doi.org/10.2174/1573406054368710