Syntheses of Disaccharide Units of Manβ (1→6)Man, Man (1→6)Manα and Glcα (1→6)Man, and Their Interactions for Concanavalin A

Title: Syntheses of Disaccharide Units of Manβ (1→6)Man, Man (1→6)Manα and Glcα (1→6)Man, and Their Interactions for Concanavalin A

Volume: 3 Issue: 8

Author(s): Takashi Yamanoi, Hitomi Hamada, Yoshiki Oda and Kenjiro Hattori

Affiliation:

Keywords: Concanavalin A, β1,6-linked disaccharide, Mannodisaccharide, Association constant, Dimethylphosphinothioate, SPR

Abstract: We investigated the synthesis of the disaccharide units of Manβ(1→ 6)Manα1→ OPh, Manα(1→ 6)Manα1→ OPh and Glcα(1→ 6)Manβ1→ OPh as the analogues of the α(1→6) arm of the mannotrisaccharide core in N-linked glycopeptides using the dimethylphosphinothioate method. Studies using a surface plasmon resonance optical biosensor indicated that the Manβ(1→6)Manα1→ OPh had an association constant of 1.15 104 M-1 for immobilized Concanavalin A, which almost corresponded to that of the Manα(1→ 6)Manα1→ OPh.

Cite this article as:

Yamanoi Takashi, Hamada Hitomi, Oda Yoshiki and Hattori Kenjiro, Syntheses of Disaccharide Units of Manβ (1→6)Man, Man (1→6)Manα and Glcα (1→6)Man, and Their Interactions for Concanavalin A, Letters in Drug Design & Discovery 2006; 3 (8) . https://dx.doi.org/10.2174/157018006778194763

DOI https://dx.doi.org/10.2174/157018006778194763	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X