Biochemical Markers of Impending Psychosis

Title: Biochemical Markers of Impending Psychosis

Volume: 18 Issue: 4

Author(s): Enzo Emanuele, Valentina Martinelli, Vera Abbiati, Paolo Fusar-Poli and Pierluigi Politi

Affiliation:

Keywords: Biomarkers, at risk mental states, prodromal symptoms, psychosis, neurotrophins, oxidative stress, cannabinoids, schizophrenia, Mass spectrometry, cytokines

Abstract: Recent years have witnessed numerous attempts at identifying the biological correlates of impending psychosis. Biochemical markers may theoretically provide a powerful approach to identify at-risk individuals, potentially leading to more effective intervention strategies to treat them. Hopefully, future developments in the field of research biochemistry in patients with at risk mental states or prodromal symptoms will make this approach ideal for screening and monitoring purposes. In this review, we provide an overview of the different biochemical markers which have been recently demonstrated to be altered in the biological fluids of patients with impending psychosis. We will also examine the practical issues that seem to be limiting the effective integration of biomarkers into clinical development.

Cite this article as:

Emanuele Enzo, Martinelli Valentina, Abbiati Vera, Fusar-Poli Paolo and Politi Pierluigi, Biochemical Markers of Impending Psychosis, Current Pharmaceutical Design 2012; 18 (4) . https://dx.doi.org/10.2174/138161212799316000