Abstract
During last decade the field of Organocatalysis emerged as one of the cornerstones of organic asymmetric synthesis. The use of organocatalysis has some advantages such as metal free reactions, environmentally friendly conditions, does not need to use dry solvents or inert atmosphere, avoid the use of protecting groups, etc … For these reasons, several research groups have focused their efforts on the development of new organocatalytic methodologies that render the final products in excellent yields and stereoselectivities. Concretely, the organocatalytic synthesis of 5 and 6 membered heterocycles has attracted much attention. In this review we have the aim to describe the different organocatalytic methodologies developed since in the synthesis of 5 and 6 heterocycles.
Keywords: Organocatalysis, Michael reaction, 3+2 cycloaddition, diels-Alder, domino reaction, heterocylic rings, organic chemistry, Synthesis of Azacycles, Pyrrolidines, Saturated Heterocycles, Nitrogen, addition-cyclization, 1,3-dipolar cycloaddition, nitroaldehydes, homoproline derivatives
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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