Abstract
Over the last few decades, the catalytic asymmetric Friedel-Crafts alkylation has become a powerful strategy that provides enantioenriched structural motifs of established value in medicinal chemistry or complex target synthesis. While the traditionally chiral Lewis-acid catalyzed Friedel-Crafts alkylation has been extensively reviewed in the literature, we focused this review on the recent advances on organocatalytic Friedel-Crafts alkylations. According to activation modes, this review is divided into three main sections, including 1) alkylations via iminium catalysis, 2) alkylations via SOMO catalysis, and 3) alkylations by chiral hydrogen-bond donors.
Keywords: Organocatalysis, Friedel-Crafts alkylation, iminium catalysis, SOMO catalysis, hydrogen-bonding catalysis, Enantioselective, chiral amine catalysts, organometallic/bioorganic methods, carbon-carbon, carbon-heteroatom, α β-unsaturated aldehydes, organic synthesis, Alkylation with Enals, covalent, alkylation chemistry
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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