Abstract
Combined reactions through organoboron intermediates belong to the class of sequential reactions whereby the advantages are clear in terms of efficiency and selectivity. The goal to prepare target molecules from simple substrates requires strategic steps and very selective formation of new bonds. The addition of boryl units to unsaturated substrates can be performed chemo-, regio- and stereoselectively, therefore the organoboron intermediates might be easily transformed into the functionalized molecules, with total retention of configuration. Taking advantage of these protocols, here we describe the most recent advances in combined reactions through B chemistry.
Keywords: Cross-coupling, bis(pinacolato)diboron, bis(catecholato)diboron, boration, dimerization, cyclization, Organic Reactions, organic synthesis, building blocks, organoboronic esters, reductive elimination, oxidative addition, Transition metal-catalyzed, atom-economical manner, crystalline materials
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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