Abstract
Its outstanding ability to generate singlet oxygen or reactive oxygen species upon irradiation with light makes hypericin one of the most powerful photosensitizers to be found in Nature. The most important fields of application of hypericin seem presently to be its use as a photosensitizing antiviral agent to destroy virus particles in blood preparations, to sensitize the destruction of superficial tumors, and its use as a diagnostic tool for fluorescence detection of malignant tissue.
Despite all of its benefits and its strong photosensitizing ability, the application of hypericin in photodynamic therapy (PDT) suffers from three main disadvantages: cost intensive isolation from natural sources, limited solubility under physiological conditions, and long wavelength absorption maximum outside the optimum wavelength range for a PDT photosensitizer. Thus, over the last years several efforts have been undertaken to synthesize new hypericin derivatives with increased solubility, a bathochromically shifted long wavelength absorption band, enhanced photosensitizing potential, and applicability to a more widespread field (second generation hypericin based photosensitizers). The objective of this review is to discuss the investigations undertaken in the development of second generation hypericin based photosensitizers. The focus will be on the synthesis of such derivatives as well as on their photochemical properties, their advantages, and disadvantages. Several of these novel synthetic hypericin derivatives have already been tested in vitro and/or in vivo. Accordingly, a summary of the corresponding results will be presented.
Keywords: Phenanthroperylene Quinones, Photodynamic Therapy, Photosensitizers, Emodin, Photochemistry, Natural Compounds, Semisynthesis Approaches, Cancer, viruses, retroviruses, microorganisms, photodynamic, photosensitizer, hypericism, HIV infection
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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