Opioid Receptor-Like (ORL1) Receptor Utilizes Both GoA and GoB for Signal Transductio

Title: Opioid Receptor-Like (ORL1) Receptor Utilizes Both GoA and GoB for Signal Transductio

Volume: 13 Issue: 5

Author(s): Prudence H. Tso and Yung H. Wong

Affiliation:

Keywords: Adenylyl cyclase, ERK, G proteins, ORL1 receptor, signal transduction, superactivation

Abstract: The ORL1 receptors stably expressed in HEK 293 cells can utilize PTX-resistant mutants of GαoA/B to inhibit adenylyl cyclase (AC) and stimulate extracellular signal-regulated protein kinases (ERKs). However, development of AC superactivation and loss of ERK1/2 responsiveness induced by chronic activation of the ORL1 receptors remained PTXsensitive.

Cite this article as:

Tso H. Prudence and Wong H. Yung, Opioid Receptor-Like (ORL1) Receptor Utilizes Both GoA and GoB for Signal Transductio, Protein & Peptide Letters 2006; 13 (5) . https://dx.doi.org/10.2174/092986606776819547

DOI https://dx.doi.org/10.2174/092986606776819547	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305