Abstract
Tri-substituted oxazoles, appearing in several anticancer natural products and various other bioactive compounds, have become increasingly visible in recent years. Research into the synthesis of such oxazoles has led to the development of new synthetic methods as well as refinements of classic methods of their synthesis. In addition, a number of research groups have pursued the synthesis of fully-functionalized-oxazole-containing natural products. We review recent investigations (2004-present) into methods of tri-substituted oxazole synthesis, and the construction of complex natural products containing such oxazoles.
Keywords: Methodology, natural product, tri-substituted oxazole, heterocycles, review, total synthesis, drug discovery, Tri-substituted oxazoles, Nitrogenous heterocycles, myriad, Telomestatin, anticancer activities, Martefragin A, Siphonazole
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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