Abstract
Cyclodextrins bearing pendant cationic or anionic moieties have been shown to form highly stable inclusion complexes with oppositely charged organic molecules. These charged hosts are also capable of molecular recognition of various organic cations and anions such as nucleotides and other phosphates, sulfates, sulfonates, carboxylates, enantiomers of amino acids, bile acids and many others. This review summarizes work in this field published till the year 2009 including most common synthetic methods for the preparation of charged cyclodextrin derivatives and examples of their applications in bioorganic chemistry and pharmacy.
Keywords: Cyclodextrins, ionic interactions, host-guest complexes, inclusion complexes
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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