Energy Metabolism Dysregulation in Myocardial Infarction: An Integrative Analysis of Ischemic Cardiomyopathy

Title:Energy Metabolism Dysregulation in Myocardial Infarction: An Integrative Analysis of Ischemic Cardiomyopathy

Volume: 22

Author(s): Zongtao Wang, Zhixin Xie, Tudi Li, Rong Chen, Zhihuan Zeng and Jun Guo*

Affiliation:

• Department of Cardiology and The First Affiliated Hospital of Jinan University, Guangzhou, China

Abstract: Background: Myocardial metabolism is closely related to functional changes after myocardial infarction (MI).

Objective: This study aimed to present an integrative examination of human ischemic cardiomyopathy.

Methods: We used both GSE121893 single-cell suspension sequencing and GSE19303 transcription microarray data sets from the GEO database, along with a murine MI model for full-spectrum metabolite detection. Through a systematic investigation that involved differential metabolite identification and functional enrichment analysis, we shed light on the pivotal role of energy metabolism dysregulation in the progression of MI.

Results: Our findings revealed an association between the core regulatory genes CDKN1A, FOS, ITGB4, and MAP2K1 and the underlying pathophysiology of the disease. These genes are identified as critical elements in the complex landscape of myocardial ischemic disorder, highlighting novel insights into therapeutic targets and the intricate biological mechanisms involved.

Conclusion: This analysis provides a framework for future research on the metabolic alterations associated with MI.

Cite this article as:

Wang Zongtao, Xie Zhixin, Li Tudi, Chen Rong, Zeng Zhihuan and Guo Jun*, Energy Metabolism Dysregulation in Myocardial Infarction: An Integrative Analysis of Ischemic Cardiomyopathy, Current Vascular Pharmacology 2024; 22 () . https://dx.doi.org/10.2174/0115701611289159240724114844

DOI https://dx.doi.org/10.2174/0115701611289159240724114844	Print ISSN 1570-1611
Publisher Name Bentham Science Publisher	Online ISSN 1875-6212