Abstract
This study outlines the development of a novel approach utilizing microwave assistance for the alcohol dehydrogenative reaction. The process is catalyzed by manganese (II) and cobalt (II) in conjunction with chroman-4-one amino ligands. This research introduces a unique catalytic system capable of synthesizing various heterocyclic compounds, including pyrroles, pyridines, Betti bases, chromenes, and coumarins via alcohol dehydrogenation. The synthesis involved the preparation and characterization of a series of chroman- 4-one amino ligands (C1-C6) using standard analytical techniques. These ligands, in combination with MnCl2‧4H2O and CoCl2, demonstrated remarkable catalytic activity, effectively driving alcohol dehydrogenation. The catalytic cycle was initiated by the in-situ formation of metal complexes with the ligands during the reaction. Characterization using ESI-MS confirmed the presence of metal complexes (Int-1) and other intermediates (Int-II and Int-III) throughout the catalytic cycle. Additionally, the controlled experiment corroborated the efficacy of the catalytic system, evidenced by the evolution of H2 gas.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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