Abstract
Aims: This study aimed to employ sustainable green methods in the synthesis of bisfused cycles incorporating pyrido[2,3-d]pyrimidine moiety using a green catalyst nano ZnO catalyst by one-pot, multicomponent reaction among 2,2'-(propane-1,3-diylbis(sulfanediyl)) bis(6-aminopyrimidin-4(3H)-one) 3, 1H-indene-1,3(2H)-dione 4, and aromatic aldehydes 5.
Method: The reactions proceeded with both conventional and microwave (MW) irradiation methods.
Result: The microwave-assisted method carried out the reaction in 10 min and had high yields (89-95%).
Conclusion: A molecular docking simulation study was conducted using human serum albumin (PDB: ID (2XVQ)). The study revealed that compounds strongly fit into the active sites of the target protein.
