Research Progress of Natural Products with the Activity of Anti-nonalcoholic Steatohepatitis

Title:Research Progress of Natural Products with the Activity of Anti-nonalcoholic Steatohepatitis

Volume: 24 Issue: 21

Author(s): Rui Wang, Yuheng Mao, Chunping Yu, Zhenji Rong, Ruyue Wang, Yixin Wang, Linjin Lv, Yang Gao, Zhigang Wang*Hailong Zhang*

Affiliation:

• Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150040, China

• School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China

Abstract: Nonalcoholic steatohepatitis (NASH), a multi-target disease, is becoming a global epidemic. Although several anti-NASH drug candidates are being evaluated in late-stage clinical trials, none have been approved by the FDA to date. Given the global prevalence of the disease, the lack of effective drugs, and the very limited therapeutic efficacy of most of the existing synthetic drugs focusing on a single target, there is an urgent need to continue to develop new therapeutic agents. In contrast, many natural products, including pure compounds and crude extracts, possess hepatoprotective activities. Usually, these natural components are characterized by multi-targeting and low side effects. Therefore, natural products are important resources for the development of new anti- NASH drugs. In this paper, we focus on reviewing the anti-NASH potential, structure, and some of the side effects of natural products based on structural classification. We hope this mini-review will help researchers design and develop new anti-NASH drugs, especially based on the structure of natural products.

Cite this article as:

Wang Rui, Mao Yuheng, Yu Chunping, Rong Zhenji, Wang Ruyue, Wang Yixin, Lv Linjin, Gao Yang, Wang Zhigang*, Zhang Hailong*, Research Progress of Natural Products with the Activity of Anti-nonalcoholic Steatohepatitis, Mini-Reviews in Medicinal Chemistry 2024; 24 (21) . https://dx.doi.org/10.2174/0113895575306598240503054317