ANRIL: A Long Noncoding RNA in Age-related Diseases

Title:ANRIL: A Long Noncoding RNA in Age-related Diseases

Volume: 24 Issue: 21

Author(s): Rui Wang, Qi Yuan, Yuan Wen, Yifan Zhang, Yaqi Hu, Shuwen Wang and Chengfu Yuan*

Affiliation:

• Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China
• Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University
• College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China

Abstract: The intensification of the aging population is often accompanied by an increase in agerelated diseases, which impair the quality of life of the elderly. The characteristic feature of aging is progressive physiological decline, which is the largest cause of human pathology and death worldwide. However, natural aging interacts in exceptionally complex ways within and between organs, but its underlying mechanisms are still poorly understood. Long non-coding RNA (lncRNA) is a type of noncoding RNA that exceeds 200 nucleotides in length and does not possess protein-coding ability. It plays a crucial role in the occurrence and development of diseases. ANRIL, also known as CDKN2B-AS1, is an antisense ncRNA located at the INK4 site. It can play a crucial role in agerelated disease progression by regulating single nucleotide polymorphism, histone modifications, or post-transcriptional modifications (such as RNA stability and microRNA), such as cardiovascular disease, diabetes, tumor, arthritis, and osteoporosis. Therefore, a deeper understanding of the molecular mechanisms of lncRNA ANRIL in age-related diseases will help provide new diagnostic and therapeutic targets for clinical practice.

Cite this article as:

Wang Rui, Yuan Qi, Wen Yuan, Zhang Yifan, Hu Yaqi, Wang Shuwen and Yuan Chengfu*, ANRIL: A Long Noncoding RNA in Age-related Diseases, Mini-Reviews in Medicinal Chemistry 2024; 24 (21) . https://dx.doi.org/10.2174/0113895575295976240415045602