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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

Histaminergic System and Vestibular Function in Normal and Pathological Conditions

Author(s): Brahim Tighilet*, Jessica Trico, Emna Marouane, Andreas Zwergal and Christian Chabbert

Volume 22, Issue 11, 2024

Published on: 19 March, 2024

Page: [1826 - 1845] Pages: 20

DOI: 10.2174/1570159X22666240319123151

Price: $65

Abstract

Most neurotransmitter systems are represented in the central and peripheral vestibular system and are thereby involved both in normal vestibular signal processing and the pathophysiology of vestibular disorders. However, there is a special relationship between the vestibular system and the histaminergic system. The purpose of this review is to document how the histaminergic system interferes with normal and pathological vestibular function. In particular, we will discuss neurobiological mechanisms such as neuroinflammation that involve histamine to modulate and allow restoration of balance function in the situation of a vestibular insult. These adaptive mechanisms represent targets of histaminergic pharmacological compounds capable of restoring vestibular function in pathological situations. The clinical use of drugs targeting the histaminergic system in various vestibular disorders is critically discussed.

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