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The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Review Article

New Aspects of the Medicinal Value of Cornsilk: A Review

Author(s): Priyansha Bhatia, Sushma Chaturvedi*, Sonika Shrivastav and Md Sabir Alam

Volume 15, Issue 1, 2025

Published on: 14 March, 2024

Article ID: e140324227982 Pages: 10

DOI: 10.2174/0122103155272229240305111959

Price: $65

Abstract

Cornsilk has been a natural remedy for centuries to treat various medical conditions. Recent research shows the anti-inflammatory activities of cornsilk extract, which can help relieve pain. Certain biopeptides are involved in the induction of anti-inflammatory action in the administration of cornsilk extract. The analgesic activity of cornsilk is due to the presence of tannins and polyphenolic constituents in Zea mays. Besides maysin, many other factors, such as steroids, flavonoids, volatile oils, and various phenolic compounds, make cornsilk extract a modern anti-inflammatory and analgesic drug with minor side effects. In diverse cultures and folk medicines, cornsilk is used for its diuretic properties, reduction in melanin production properties, and antioxidant, anti-inflammatory, and analgesic properties. Silver nanoparticles using a combined extract of cornsilk, parsley, and Arabic gum extract have been reported to reduce inflammation. These effects have been observed in vivo. This formulation has anti-microbial as well as antioxidant properties. This review article focuses on the newer aspects of the medicinal value of cornsilk.

[1]
Kumar, B. Maize biology: An introduction, directorate of maize, research; Indian Council of Agricultural Research, 2012.
[2]
Parle, M.; Dhamija, I. Zea maize: A modern craze. Int Res J Pharm, 2013, 4(6), 9-43.
[3]
Vijitha, T.P. Corn Silk- A medicinal boon, international journal of chemtech research. CODEN (USA). IJCRGG, 2017, 10, 129-137.
[4]
Abendroth, L.J.; Elmore, R.W.; Boyer, M.J.; Marlay, S.K. Corn Growth and Development. Iowa State Univ. Extension Publication, 2011.
[5]
Guo, J.; Liu, T.; Han, L.; Liu, Y. The effects of corn silk on glycaemic metabolism. Nutr. Metab. , 2009, 6(1), 47.
[http://dx.doi.org/10.1186/1743-7075-6-47] [PMID: 19930631]
[6]
Hasanudin, K.; Hashim, P.; Mustafa, S. Corn silk (Stigma maydis) in healthcare: A phytochemical and pharmacological review. Molecules, 2012, 17(8), 679-715.
[7]
Morandi, A.; Sartori, G.; Tosto, C. Ayurveda-LaMedicina tradizionale Indiana. In: Le Medicine Non Convenzionali in Italia – Storia, Problemi e Prospettive di Integrazione; Giarrelli, G.; di Sarsina, P.R.; Bilvestrini, B., Eds.; Franco Angeli: Milan, Italy, 2007, pp. 291-309.
[8]
Datta, H.S.; Mitra, S.K.; Patwardhan, B. Wound healing activity of topical application forms based on ayurveda. Evid. Based Complement. Alternat. Med., 2011, 2011, 1-10.
[http://dx.doi.org/10.1093/ecam/nep015] [PMID: 19252191]
[9]
Saper, R.B.; Phillips, R.S.; Sehgal, A.; Khouri, N.; Davis, R.B.; Paquin, J.; Thuppil, V.; Kales, S.N. Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet. JAMA, 2008, 300(8), 915-923.
[http://dx.doi.org/10.1001/jama.300.8.915] [PMID: 18728265]
[10]
Wang, B.; Xiao, T.; Ruan, J.; Liu, W. Beneficial effects of corn silk on metabolic syndrome. Curr. Pharm. Des., 2017, 23(34), 5097-5103.
[PMID: 28950827]
[11]
Yeşilada, E.; Honda, G.; Sezik, E.; Tabata, M.; Fujita, T.; Tanaka, T.; Takeda, Y.; Takaishi, Y. Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains. J. Ethnopharmacol., 1995, 46(3), 133-152.
[http://dx.doi.org/10.1016/0378-8741(95)01241-5] [PMID: 7564412]
[12]
Cáceres, A.; Girón, L.M.; Martínez, A.M. Diuretic activity of plants used for the treatment of urinary ailments in guatemala. J. Ethnopharmacol., 1987, 19(3), 233-245.
[http://dx.doi.org/10.1016/0378-8741(87)90001-8] [PMID: 3669686]
[13]
Wang, G.Q.; Xu, T.; Bu, X.M.; Liu, B.Y. Anti-inflammation effects of corn silk in a rat model of carrageenin-induced pleurisy. Inflammation, 2012, 35(3), 822-827.
[http://dx.doi.org/10.1007/s10753-011-9382-9] [PMID: 21898269]
[14]
Mehra, R.; Makhija, R.; Vyas, N. A clinical study on the role of Ksara Vasti and Triphala Guggulu in Raktarsha (Bleeding piles). Ayu, 2011, 32(2), 192-195.
[http://dx.doi.org/10.4103/0974-8520.92572] [PMID: 22408301]
[15]
Sahib, A.; Mohammed, I.; Hamdan, S. Use of aqueous extract of corn silk in the treatment of urinary tract infection. J. Intercult. Ethnopharmacol., 2012, 1(2), 93.
[http://dx.doi.org/10.5455/jice.20120525123150]
[16]
Grases, F.; March, J.G.; Ramis, M.; Costa-Bauzá, A. The influence of Zea mays on urinary risk factors for kidney stones in rats. Phytother. Res., 1993, 7(2), 146-149.
[http://dx.doi.org/10.1002/ptr.2650070210]
[17]
Okokon, JE. Edem, UA Antiulcerogenic activity of Cornsilk extract of Zea mays. World Journal. Pharm. Research., 2020, 9(2), 117-126.
[18]
Guo, H.; Guan, H.; Yang, W.; Liu, H.; Hou, H.; Chen, X.; Liu, Z.; Zang, C.; Liu, Y.; Liu, J. Pro-apoptotic and anti-proliferative effects of corn silk extract on human colon cancer cell lines. Oncol. Lett., 2017, 13(2), 973-978.
[http://dx.doi.org/10.3892/ol.2016.5460] [PMID: 28356987]
[19]
Shi, S.; Li, S.; Li, W.; Xu, H. Corn silk tea for hypertension: A systematic review and meta-analysis of randomized controlled trials. Evid. Based Complement. Alternat. Med., 2019, 2019, 1-7.
[http://dx.doi.org/10.1155/2019/2915498] [PMID: 30792743]
[20]
Liu, J.; Lin, S.; Wang, Z.; Wang, C.; Wang, E.; Zhang, Y.; Liu, J. Supercritical fluid extraction of flavonoids from Maydis stigma and its nitrite-scavenging ability. Food Bioprod. Process., 2011, 89(4), 333-339.
[http://dx.doi.org/10.1016/j.fbp.2010.08.004]
[21]
Snook, M.E.; Widstrom, N.W.; Wiseman, B.R.; Byrne, P.F.; Harwood, J.S.; Costello, C.E. New C-4”-hyroxy derivatives of maysin and 3′-methoxymaysin isolated from corn silks (Zea mays). J. Agric. Food Chem., 1995, 43(10), 2740-2745.
[http://dx.doi.org/10.1021/jf00058a036]
[22]
Elliger, C.A.; Chan, B.G.; Waiss, A.C., Jr; Lundin, R.E.; Haddon, W.F. C-Glycosylflavones from Zea mays that inhibit insect development. Phytochemistry, 1980, 19(2), 293-297.
[http://dx.doi.org/10.1016/S0031-9422(00)81977-9]
[23]
Limmatvapirat, C.; Nateesathittarn, C.; Dechasathian, K.; Moohummad, T.; Chinajitphan, P.; Limmatvapirat, S. Phytochemical analysis of baby corn silk extracts. J. Ayurveda Integr. Med., 2020, 11(3), 344-351.
[http://dx.doi.org/10.1016/j.jaim.2019.10.005] [PMID: 32165017]
[24]
Snook, M.E.; Widstrom, N.W.; Wiseman, B.R.; Byrne, P.F.; Harwood, J.S.; Costello, C.E. New C-4′'-hydroxy derivatives of maysin and 3′-methoxymaysin isolated from corn silks (Zea mays). J. Agric. Food Chem., 1995, 43(10), 2740-2745.
[http://dx.doi.org/10.1021/jf00058a036]
[25]
Ren, S.C.; Liu, S.L.; Ding, X.L. Isolation and identification of two novel flavone glycosides from corn silk (Stigma maydis). J. Med. Plants Res., 2009, 32, 1009-1015.
[26]
Lapčík, L.; Řepka, D.; Lapčíková, B.; Sumczynski, D.; Gautam, S.; Li, P.; Valenta, T. A physicochemical study of the antioxidant activity of corn silk extracts. Foods, 2023, 12(11), 2159.
[http://dx.doi.org/10.3390/foods12112159] [PMID: 37297404]
[27]
Tian, Shuangqi.; Sun, Yue. Chen, Zhicheng Extraction of flavonoids from corn silk and biological activities in vitro. J. Food Quality., 2021, 2021, 9.
[http://dx.doi.org/10.1155/2021/7390425]
[28]
El-Ghorab, A.; El-Massry, K.F.; Shibamoto, T. Chemical composition of the volatile extract and antioxidant activities of the volatile and nonvolatile extracts of Egyptian corn silk (Zea mays L.). J. Agric. Food Chem., 2007, 55(22), 9124-9127.
[http://dx.doi.org/10.1021/jf071646e] [PMID: 17914872]
[29]
Singh, J.; Rasane, P.; Nanda, V.; Kaur, S. Bioactive compounds of corn silk and their role in management of glycaemic response. J. Food Sci. Technol., 2023, 60(6), 1695-1710.
[http://dx.doi.org/10.1007/s13197-022-05442-z] [PMID: 37187994]
[30]
Ingle, K.P.; Deshmukh, A.G.; Padole, D.A.; Dudhare, M.S.; Moharil, M.P.; Khelurkar, V.C. Phytochemicals: Extraction methods, identification, and detection of bioactive compounds from plant extracts. J. Pharmacogn. Phytochem., 2017, 6, 32-36.
[31]
Pandey, A.; Tripathi, S. Concept of standardization, extraction, and pre-phytochemical screening strategies for herbal drug. J. Pharmacogn. Phytochem., 2014, 2, 115-119.
[32]
Harborne JB Phytochemical methods: A guide to modern techniques of plant analysis. In: UKThomson Science; New York, NY: London 1998, 219.
[33]
Azwanida, N.N. A review on the extraction methods use in medicinal plants, principle, strength, and limitation. Med. Aromat. Plants, 2015, 4, 196.
[34]
Altemimi, A.; Lakhssassi, N.; Baharlouei, A.; Watson, D.; Lightfoot, D. Phytochemicals: Extraction, isolation, and identification of bioactive compounds from plant extracts. Plants, 2017, 6(4), 42.
[http://dx.doi.org/10.3390/plants6040042] [PMID: 28937585]
[35]
Nurraihana, H.; Wan Rosli, W.I.; Sabreena, S.; Norfarizan-Hanoon, N.A. Optimisation extraction procedure and identification of phenolic compounds from fractional extract of corn silk (Zea mays hair) using LC-TOF/MS system. J. Food Meas. Charact., 2018, 12(3), 1852-1862.
[http://dx.doi.org/10.1007/s11694-018-9799-z]
[36]
Habtemariam, S. Extract of corn silk (stigma of Zea mays) inhibits the tumour necrosis factor-α- and bacterial lipopolysaccharide-induced cell adhesion and ICAM-1 expression. Planta Med., 1998, 64(4), 314-318.
[http://dx.doi.org/10.1055/s-2006-957441] [PMID: 9619111]
[37]
Kim, S.R.; Ha, A.W.; Choi, H.J.; Kim, S.L.; Kang, H.J.; Kim, M.H.; Kim, W.K. Corn silk extract improves benign prostatic hyperplasia in experimental rat model. Nutr. Res. Pract., 2017, 11(5), 373-380.
[http://dx.doi.org/10.4162/nrp.2017.11.5.373] [PMID: 28989573]
[38]
Hu, Q.L.; Zhang, L.J.; Li, Y.N.; Ding, Y.J.; Li, F.L. Purification and anti-fatigue activity of flavonoids from corn silk. Int. J. Phys. Sci., 2010, 5, 321-326.
[39]
Ebrahimzadeh, M.A.; Mahmoudi, M.; Ahangar, N.; Ehteshami, S.; Ansaroudi, F.; Nabavi, S.F.; Nabavi, S.M. Anti-depressant activity of corn silk. Pharmacologyonline, 2009, 3, 647-652.
[40]
Velazquez, D.V.O.; Xavier, H.S.; Batista, J.E.M.; de Castro-Chaves, C. Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats. Phytomedicine, 2005, 12(5), 363-369.
[http://dx.doi.org/10.1016/j.phymed.2003.12.010] [PMID: 15957371]
[41]
Qing lan, H.; Zhi hong, D. Protective effects of flavonoids from corn silk on oxidative stress induced by exhaustive exercise in mice. Afr. J. Biotechnol., 2011, 10(16), 3163-3167.
[http://dx.doi.org/10.5897/AJB10.2671]
[42]
Li, C.C.; Lee, Y.C.; Lo, H.Y.; Huang, Y.W.; Hsiang, C.Y.; Ho, T.Y. Antihypertensive effects of corn silk extract and its novel bioactive constituent in spontaneously hypertensive rats: The involvement of angiotensin-converting enzyme inhibition. Molecules, 2019, 24(10), 1886.
[http://dx.doi.org/10.3390/molecules24101886] [PMID: 31100914]
[43]
Hashim, P. Centella asiatica in food and beverage applications and its potential antioxidant and neuroprotective effect. J. Int. Food Res., 2011, 18, 2217-2222.
[44]
Liu, J.; Wang, C.; Wang, Z.; Zhang, C.; Lu, S.; Liu, J. The antioxidant and free-radical scavenging activities of extract and fractions from corn silk (Zea mays L.) and related flavone glycosides. Food Chem., 2011, 126(1), 261-269.
[http://dx.doi.org/10.1016/j.foodchem.2010.11.014]
[45]
Nandi, A.; Yan, L.J.; Jana, C.K.; Das, N. Role of catalase in oxidative stress- and age-associated degenerative diseases. Oxid. Med. Cell. Longev., 2019, 2019, 1-19.
[http://dx.doi.org/10.1155/2019/9613090] [PMID: 31827713]
[46]
Martínez, M.C.; Andriantsitohaina, R. Reactive nitrogen species: Molecular mechanisms and potential significance in health and disease. Antioxid. Redox Signal., 2009, 11(3), 669-702.
[http://dx.doi.org/10.1089/ars.2007.1993] [PMID: 19014277]
[47]
Maksimović, Z.; Malenčić, Đ.; Kovačević, N. Polyphenol contents and antioxidant activity of Maydis stigma extracts. Bioresour. Technol., 2005, 96(8), 873-877.
[http://dx.doi.org/10.1016/j.biortech.2004.09.006] [PMID: 15627557]
[48]
Fougère, L.; Zubrzycki, S.; Elfakir, C.; Destandau, E. Characterization of corn silk extract using HPLC/HRMS/MS analyses and bioinformatic data processing. Plants, 2023, 12(4), 721.
[http://dx.doi.org/10.3390/plants12040721] [PMID: 36840069]
[49]
Bahorun, T.; Soobrattee, M.A.; Luximon-Ramma, V.; Aruoma, O.I. Free radicals and antioxidants in cardiovascular health and disease. Internet Journal of Medical Update., 2006, 1, 1-17.
[50]
Halliwell, B. Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment. Drugs Aging, 2001, 18(9), 685-716.
[http://dx.doi.org/10.2165/00002512-200118090-00004] [PMID: 11599635]
[51]
Willcox, J.K.; Ash, S.L.; Catignani, G.L. Antioxidants and prevention of chronic disease. Crit. Rev. Food Sci. Nutr., 2004, 44(4), 275-295.
[http://dx.doi.org/10.1080/10408690490468489] [PMID: 15462130]
[52]
Valko, M.; Izakovic, M.; Mazur, M.; Rhodes, C.J.; Telser, J. Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell. Biochem., 2004, 266(1/2), 37-56.
[http://dx.doi.org/10.1023/B:MCBI.0000049134.69131.89] [PMID: 15646026]
[53]
MacNee, W. Oxidative stress and lung inflammation in airways disease. Eur. J. Pharmacol., 2001, 429(1-3), 195-207.
[http://dx.doi.org/10.1016/S0014-2999(01)01320-6] [PMID: 11698041]
[54]
Galle, J. Oxidative stress in chronic renal failure. Nephrol. Dial. Transplant., 2001, 16(11), 2135-2137.
[http://dx.doi.org/10.1093/ndt/16.11.2135] [PMID: 11682656]
[55]
Mahajan, A.; Tandon, V.R. Antioxidants and rheumatoid arthritis. Journal of Indian Rheumatology Association., 2004, 12, 139-142.
[56]
Samuel, J.B.; Stanley, J.A.; Princess, R.A.; Shanthi, P.; Sebastian, M.S. Gestational cadmium exposure-induced ovotoxicity delays puberty through oxidative stress and impaired steroid hormone levels. J. Med. Toxicol., 2011, 7(3), 195-204.
[http://dx.doi.org/10.1007/s13181-011-0143-9] [PMID: 21373971]
[57]
Beckman, K.B.; Ames, B.N. The free radical theory of aging matures. Physiol. Rev., 1998, 78(2), 547-581.
[http://dx.doi.org/10.1152/physrev.1998.78.2.547] [PMID: 9562038]
[58]
Pole, A.; Dimri, M.; Dimri, G. Oxidative stress, cellular senescence and ageing. AIMS Mol. Sci., 2016, 3(3), 300-324.
[http://dx.doi.org/10.3934/molsci.2016.3.300]
[59]
Khansari, N.; Shakiba, Y.; Mahmoudi, M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat. Inflamm. Allergy Drug Discov., 2009, 3(1), 73-80.
[http://dx.doi.org/10.2174/187221309787158371] [PMID: 19149749]
[60]
Abeyrathne, E.D.N.S.; Nam, K.; Huang, X.; Ahn, D.U. Plant- and animal-based antioxidants’ structure, efficacy, mechanisms, and applications: A review. Antioxidants, 2022, 11(5), 1025.
[http://dx.doi.org/10.3390/antiox11051025] [PMID: 35624889]
[61]
Padayatty, S.J.; Katz, A.; Wang, Y.; Eck, P.; Kwon, O.; Lee, J.H.; Chen, S.; Corpe, C.; Dutta, A.; Dutta, S.K.; Levine, M. Vitamin C as an antioxidant: Evaluation of its role in disease prevention. J. Am. Coll. Nutr., 2003, 22(1), 18-35.
[http://dx.doi.org/10.1080/07315724.2003.10719272] [PMID: 12569111]
[62]
Frankel, E.N. The antioxidant and nutritional effects of tocopherols, ascorbic acid and beta-carotene in relation to processing of edible oils. Bibl. Nutr. Dieta, 1989, (43), 297-312.
[PMID: 2658965]
[63]
Panche, A.N.; Diwan, A.D.; Chandra, S.R. Flavonoids: An overview. J. Nutr. Sci., 2016, 5, e47.
[http://dx.doi.org/10.1017/jns.2016.41] [PMID: 28620474]
[64]
Zeb, A. Concept, mechanism, and applications of phenolic antioxidants in foods. J. Food Biochem., 2020, 44(9), e13394.
[http://dx.doi.org/10.1111/jfbc.13394] [PMID: 32691460]
[65]
Carlsen, M.H.; Halvorsen, B.L.; Holte, K.; Bøhn, S.K.; Dragland, S.; Sampson, L.; Willey, C.; Senoo, H.; Umezono, Y.; Sanada, C.; Barikmo, I.; Berhe, N.; Willett, W.C.; Phillips, K.M.; Jacobs, D.R., Jr; Blomhoff, R. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr. J., 2010, 9(1), 3.
[http://dx.doi.org/10.1186/1475-2891-9-3] [PMID: 20096093]
[66]
Williams, G.M.; Iatropoulos, M.J.; Whysner, J. Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives. Food Chem. Toxicol., 1999, 37(9-10), 1027-1038.
[http://dx.doi.org/10.1016/S0278-6915(99)00085-X] [PMID: 10541460]
[67]
Ebrahimzadeh, M.A.; Pourmorad, F.; Hafe, S. Anti-oxidant activities of iranian corn silk. Turk. J. Biol., 2008, 32, 43-49.
[68]
Wang, K.; Zhao, J. Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities. Biomedicine & Pharmacotherapy., 2019, 110, 510-517.
[69]
Rabi, O.O.; Omoba, O.S.; Aderonke Ibidunni, O. In vitro antioxidants and antihypertensive properties of corn silk–lemon infusion. Bull. Natl. Res. Cent., 2022, 46(1), 46.
[http://dx.doi.org/10.1186/s42269-022-00728-w]
[70]
Alam, E.A. Evaluation of antioxidant and antibacterial activities of Egyptian Maydis stigma (Zea mays hairs) rich in some bioactive constituents. J. Am. Sci., 2011, 7, 726-729.
[71]
Karami, Mohammad An experimental model for study of the renal protective activity of corn silk against dosage induced By MDMA using in situ rat renal system. Iranian J. Toxicology, 2013, 8.
[72]
Nguyen, T.; Sherratt, P.J.; Pickett, C.B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol., 2003, 43(1), 233-260.
[http://dx.doi.org/10.1146/annurev.pharmtox.43.100901.140229] [PMID: 12359864]
[73]
Nguemfo, E.L.; Dimo, T.; Azebaze, A.G.B.; Asongalem, E.A.; Alaoui, K.; Dongmo, A.B.; Cherrah, Y.; Kamtchouing, P. Anti-inflammatory and anti-nociceptive activities of the stem bark extracts from Allanblackia monticola STANER L.C. (Guttiferae). J. Ethnopharmacol., 2007, 114(3), 417-424.
[http://dx.doi.org/10.1016/j.jep.2007.08.022] [PMID: 17913418]
[74]
Sørnes, E.Ø.; Risal, A.; Manandhar, K.; Thomas, H.; Steiner, T.J.; Linde, M. Use of medicinal plants for headache, and their potential implication in medication-overuse headache: Evidence from a population-based study in Nepal. Cephalalgia, 2021, 41(5), 561-581.
[http://dx.doi.org/10.1177/0333102420970904] [PMID: 33435708]
[75]
Zhang, H.; Jiang, H.; Zhao, M.; Xu, Y.; Liang, J.; Ye, Y.; Chen, H. Treatment of gout with TCM using turmeric and corn silk: A concise review article and pharmacology network analysis. Evid. Based Complement. Alternat. Med., 2022, 2022, 1-18.
[http://dx.doi.org/10.1155/2022/3143733] [PMID: 36276864]
[76]
Adedapo, A.A.; Babarinsa, O.S.; Ogunshe, A.A.O.; Oyagbemi, A.A.; Omobowale, T.O.; Adedapo, A.D. Evaluation of some biological activities of the extracts of corn silk and leaves. Trop Vet (Ib), 2013, 31(4), 12-32.
[77]
Namba, T.; Xu, H.; Kadota, S.; Hattori, M.; Takahashi, T.; Kojima, Y. Inhibition of IgE formation in mice by glycoproteins from corn silk. Phytother. Res., 1993, 7(3), 227-230.
[http://dx.doi.org/10.1002/ptr.2650070303]
[78]
Pinheiro, A.C.S.; Pais, A.A.; Tardivo, A.C.B. Alves MJQF Effect of aqueous extract of corn silks (Zea mays L.) on the renal excretion of water and electrolytes and arterial pressure in anesthetized wistar rats. Rev. Bras. Plantas Med., 2011, 13, 375-381.
[http://dx.doi.org/10.1590/S1516-05722011000400001]
[79]
Ramasamy, R.; Vannucci, S.J.; Yan, S.S.D.; Herold, K.; Yan, S.F.; Schmidt, A.M. Advanced glycation end products and RAGE: A common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology, 2005, 15(7), 16R-28R.
[http://dx.doi.org/10.1093/glycob/cwi053] [PMID: 15764591]
[80]
Farsi, D.A.; Harris, C.S.; Reid, L.; Bennett, S.A.L.; Haddad, P.S.; Martineau, L.C.; Arnason, J.T. Inhibition of non‐enzymatic glycation by silk extracts from a Mexican land race and modern inbred lines of maize (Zea mays). Phytother. Res., 2008, 22(1), 108-112.
[http://dx.doi.org/10.1002/ptr.2275] [PMID: 17724765]
[81]
Chan, C.C.; Zhang, H.W.; Chan, K.; Lin, Z.X. Xiaoke Pill () and anti-diabetic drugs: A review on clinical evidence of possible herb-drug interactions. Chin. J. Integr. Med., 2016.
[http://dx.doi.org/10.1007/s11655-015-2106-5] [PMID: 26825080]
[82]
Eyth, E.; Basit, H.; Swift, C.J. Glucose Tolerance Test; StatPearls Publishing: In: StatPearls [Internet]. Treasure Island 2023.
[83]
Schreiner, G.E. Toxic nephropathy. JAMA, 1965, 191(10), 849-850.
[http://dx.doi.org/10.1001/jama.1965.03080100067015] [PMID: 14250075]
[84]
Sepehri, G.; Derakhshanfar, A.; Yazdi Zadeh, F. Protective effects of corn silk extract administration on gentamicin-induced nephrotoxicity in rat. Comp. Clin. Pathol., 2011, 20(1), 89-94.
[http://dx.doi.org/10.1007/s00580-009-0943-3]
[85]
Kaup, S.R.; Arunkumar, N.; Bernhardt, L.K.; Vasavi, R.G.; Shetty, S.S.; Pai, S.R.; Arunkumar, B. Antihyperlipedemic activity of Cynodon dactylon extract in high-cholesterol diet fed Wistar rats. Genomic Medicine, Biomarkers, and Health Sciences, 2011, 3(3-4), 98-102.
[http://dx.doi.org/10.1016/j.gmbhs.2011.11.001]
[86]
Kan, A.; Orhan, I.; Coksari, G.; Sener, B. In-vitro neuroprotective properties of the Maydis stigma extracts from four corn varieties. Int. J. Food Sci. Nutr., 2012, 63(1), 1-4.
[http://dx.doi.org/10.3109/09637486.2011.590797] [PMID: 21696302]
[87]
Sheng, L.; Chen, Q.; Di, L.; Li, N. Evaluation of anti-diabetic potential of corn silk in high-fat diet/streptozotocin-induced type 2 diabetes mice model. Endocr. Metab. Immune Disord. Drug Targets, 2021, 21(1), 131-138.
[http://dx.doi.org/10.2174/1871530320666200606224708] [PMID: 32504506]
[88]
Zhao, W.; Yin, Y.; Yu, Z.; Liu, J.; Chen, F. Comparison of anti-diabetic effects of polysaccharides from corn silk on normal and hyperglycemia rats. Int. J. Biol. Macromol., 2012, 50(4), 1133-1137.
[http://dx.doi.org/10.1016/j.ijbiomac.2012.02.004] [PMID: 22353397]
[89]
Baliyan, S.; Mukherjee, R.; Priyadarshini, A. Determination of antioxidants by dpph radical scavenging activity and quantitative phytochemical analysis of ficus religiosa. Molecules, 2022, 27(4), 1326.
[90]
Yadav, A.S.; Bhatnagar, D. Free radical scavenging activity, metal chelation and antioxidant power of some of the Indian spices. Biofactors, 2007, 31(3-4), 219-227.
[http://dx.doi.org/10.1002/biof.5520310309] [PMID: 18997285]
[91]
Eliopoulos, A.G.; Dumitru, C.D.; Wang, C-C.; Cho, J.; Tsichlis, P.N. Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. EMBO J., 2002, 21(18), 4831-4840.
[http://dx.doi.org/10.1093/emboj/cdf478] [PMID: 12234923]
[92]
Kim, K.A.; Shin, H.H.; Choi, S.K.; Choi, H.S. Corn silk induced cyclooxygenase-2 in murine macrophages. Biosci. Biotechnol. Biochem., 2005, 69(10), 1848-1853.
[http://dx.doi.org/10.1271/bbb.69.1848] [PMID: 16244433]
[93]
Wang, C.; Zhang, T.; Liu, J.; Lu, S.; Zhang, C.; Wang, E.; Wang, Z.; Zhang, Y.; Liu, J. Subchronic toxicity study of corn silk with rats. J. Ethnopharmacol., 2011, 137(1), 36-43.
[http://dx.doi.org/10.1016/j.jep.2011.03.021] [PMID: 21397679]
[94]
Ha, A.W.; Kang, H.J.; Kim, S.L.; Kim, M.H.; Kim, W.K. Acute and subacute toxicity evaluation of corn silk extract. Prev. Nutr. Food Sci., 2018, 23(1), 70-76.
[http://dx.doi.org/10.3746/pnf.2018.23.1.70] [PMID: 29662850]
[95]
Sarmukaddam, S.; Chopra, A.; Tillu, G. Efficacy and safety of Ayurvedic medicines: Recommending equivalence trial design and proposing safety index. Int. J. Ayurveda Res., 2010, 1(3), 175-180.
[http://dx.doi.org/10.4103/0974-7788.72491] [PMID: 21170211]
[96]
Patra, J.K.; Baek, K.H. Biosynthesis of silver nanoparticles using aqueous extract of silky hairs of corn and investigation of its antibacterial and anticandidal synergistic activity and antioxidant potential. IET Nanobiotechnol., 2016, 10(5), 326-333.
[http://dx.doi.org/10.1049/iet-nbt.2015.0102] [PMID: 27676382]
[97]
Zhang, Y.; Liu, J.; Guan, L.; Fan, D.; Xia, F.; Wang, A.; Bao, Y.; Xu, Y. By‐Products of Zea mays L.: A promising source of medicinal properties with phytochemistry and pharmacological activities: A comprehensive review. Chem. Biodivers., 2023, 20(3), e202200940.
[http://dx.doi.org/10.1002/cbdv.202200940] [PMID: 36721262]
[98]
Stoecklin, G.; Lu, M.; Rattenbacher, B.; Moroni, C. A constitutive decay element promotes tumor necrosis factor alpha mRNA degradation via an AU-rich element-independent pathway. Mol. Cell. Biol., 2003, 23(10), 3506-3515.
[http://dx.doi.org/10.1128/MCB.23.10.3506-3515.2003] [PMID: 12724409]
[99]
Pietta, P.G. Flavonoids as antioxidants. J. Nat. Prod., 2000, 63(7), 1035-1042.
[http://dx.doi.org/10.1021/np9904509] [PMID: 10924197]

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