Investigating the Relationship between COVID-19 In-hospital Death and Acute Kidney Injury

Title:Investigating the Relationship between COVID-19 In-hospital Death and Acute Kidney Injury

Volume: 5 Issue: 4

Author(s): Ramin Haghighi, Nikoo Fereyduny, Mohammad Bagher Oghazian, Ashkan Haghighi, Amir Bigdeli*Amirhossein Sahebkar*

Affiliation:

• Department of Nephrology and Hypertension, Sayad Shirazi Hospital, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

• Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
• Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
• School of Medicine, The University of Western Australia, Perth, Australia
• Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

Introduction: Coronavirus Disease 2019 (COVID-19) can induce multiorgan failure, including acute kidney injury (AKI), which is associated with a poor prognosis. Some of these patients develop proteinuria, hematuria, and elevated serum creatinine, therefore some require hemodialysis. This study aimed to investigate the association between in-hospital death due to COVID-19 and the prevalence of AKI.

Methods: In a retrospective study, the available data of patients who died because of COVID-19 from April 1 to September 22, 2020 in a referral hospital was investigated using the case census method.

Results: A total of 190 patients who died of COVID-19 were evaluated. Of these, 111 (58.42%) had AKI, with 108 (56.84%) being male. The mean age of the subjects was 66.16±15.43 years old. The mean time from hospital admission to death was about 9 days in all patients. Although not statistically significant, the findings showed that patients who developed AKI died sooner. The most frequent underlying diseases were hypertension [n= 101 (53.16%)] and diabetes [n= 44 (23.16%)]. Moreover, a higher proportion of subjects with AKI as compared to those without AKI were admitted to the intensive care unit (ICU), and had abnormal proteinuria profile (p-value=0.045 and 0.025, respectively).

Conclusion: The prevalence of AKI was 58.42% in patients who died from COVID-19 disease. Moreover, abnormal proteinuria and ICU admission were significantly higher in COVID-19 patients with AKI than in those without AKI.

Cite this article as:

Haghighi Ramin, Fereyduny Nikoo, Oghazian Mohammad Bagher, Haghighi Ashkan, Bigdeli Amir*, Sahebkar Amirhossein*, Investigating the Relationship between COVID-19 In-hospital Death and Acute Kidney Injury, Coronaviruses 2024; 5 (4) : e290124226454 . https://dx.doi.org/10.2174/0126667975284268240109110622