Alnustone: A Review of its Sources, Pharmacology, and Pharmacokinetics

Title:Alnustone: A Review of its Sources, Pharmacology, and Pharmacokinetics

Volume: 17

Author(s): Zahra Salari, Maryam Alavi, Hojjat Rezaii-zadeh, Abdelhakim Bouyahya, Ammar Alfergah, Sahar Afsari Sardari and Ehsan Amiri Ardekani*

Affiliation:

• Students Research Committee, Shiraz University of Medical Sciences, Shiraz 71348, Iran
• Department of Phytopharmaceuticals (Traditional Pharmacy), Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz 71348, Iran
• Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz 71348, Iran

Abstract:

Alnustone (4(E)-,6(E)-1,7-Diphenyl-hepta-4,6-dien-3-one) is a non-phenolic natural diarylheptanoid, which was first isolated and identified from the male flower of Alnus pendula (Betulaceae). It can also be isolated from Curcuma xanthorrhiza Roxb (Zingiberaceae) rhizomes and Alpinia katsumadai Hayata (Zingiberaceae) seeds. It was first synthesized through a five-step process from β-phenyl propionyl chloride. In later years, new methods for synthesizing Alnustone were designed and performed with different yields. Due to the various therapeutic effects exhibited by alnustone like other diarylheptanoids, its biological activities such as antioxidant, antibacterial, and anti-inflammatory properties have been the subject of many studies.

This article has reviewed different aspects of this valuable natural compound, including its natural and synthetic sources, therapeutic effects, and pharmacokinetics as a potential future therapeutic agent.

Cite this article as:

Salari Zahra, Alavi Maryam, Rezaii-zadeh Hojjat, Bouyahya Abdelhakim, Alfergah Ammar, Afsari Sardari Sahar and Amiri Ardekani Ehsan*, Alnustone: A Review of its Sources, Pharmacology, and Pharmacokinetics, Current Molecular Pharmacology 2024; 17 : e18761429252459 . https://dx.doi.org/10.2174/0118761429252459231115060139