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Current Indian Science

Editor-in-Chief

ISSN (Print): 2210-299X
ISSN (Online): 2210-3007

Review Article

Fostemsavir: A Novel CD4 Attachment Inhibitor for Heavily Treated HIV-1 Patient

Author(s): Prince P. George, Ranjeet Kumar*, Manvi Sharma and Rojin G. Raj

Volume 1, 2023

Published on: 23 October, 2023

Article ID: e2210299X255078 Pages: 8

DOI: 10.2174/012210299X255078231011111629

open_access

Abstract

Despite the evident success of antiretroviral therapy in recent years, many patients undergoing intense treatment still struggle to find a cure for their disease due to drug resistance or treatment failure. To solve this problem, new antiretroviral drug alternatives are required. The HIV-1 antiretroviral drug fostemsavir (GSK3684394, previously BMS-663068) is a first-in-class HIV-1 attachment inhibitor with a novel mechanism. After oral administration, fostemsavir gets converted into temsavir in the gastrointestinal lumen, which then attaches to the glycoprotein 120 surface subunit on HIV-1 and produces a conformational change that prevents it from adhering to CD4+ T cells of the host immune system, thereby preventing the virus from infecting other cells. Fostemsavir is indicated in heavily treated (HTE) patients with an ideal antiretroviral (ARV) regimen. The drug has shown significant tolerability, and no hepatic or renal dose adjustments were required. Fostemsavir can be used as an effective alternative in salvage therapy because of its favourable adverse effect profile and few drug interactions.

[1]
WHO. HIV and AIDS. Available from:https://www.who.int/news-room/fact-sheets/detail/hiv-aids (accessed Nov. 11, 2022)
[2]
Hemelaar, J.; Elangovan, R.; Yun, J.; Dickson-Tetteh, L.; Fleminger, I.; Kirtley, S.; Williams, B.; Gouws-Williams, E.; Ghys, P.D.; Abimiku, A.G.; Agwale, S.; Archibald, C.; Avidor, B.; Barbás, M.G.; Barre-Sinoussi, F.; Barugahare, B.; Belabbes, E.H.; Bertagnolio, S.; Birx, D.; Bobkov, A.F.; Brandful, J.; Bredell, H.; Brennan, C.A.; Brooks, J.; Bruckova, M.; Buonaguro, L.; Buonaguro, F.; Buttò, S.; Buve, A.; Campbell, M.; Carr, J.; Carrera, A.; Carrillo, M.G.; Celum, C.; Chaplin, B.; Charles, M.; Chatzidimitriou, D.; Chen, Z.; Chijiwa, K.; Cooper, D.; Cunningham, P.; Dagnra, A.; de Gascun, C.F.; Del Amo, J.; Delgado, E.; Dietrich, U.; Dwyer, D.; Ellenberger, D.; Ensoli, B.; Essex, M.; Gao, F.; Fleury, H.; Fonjungo, P.N.; Foulongne, V.; Gadkari, D.A.; García, F.; Garsia, R.; Gershy-Damet, G.M.; Glynn, J.R.; Goodall, R.; Grossman, Z.; Lindenmeyer-Guimarães, M.; Hahn, B.; Hamers, R.L.; Hamouda, O.; Handema, R.; He, X.; Herbeck, J.; Ho, D.D.; Holguin, A.; Hosseinipour, M.; Hunt, G.; Ito, M.; Bel Hadj Kacem, M.A.; Kahle, E.; Kaleebu, P.K.; Kalish, M.; Kamarulzaman, A.; Kang, C.; Kanki, P.; Karamov, E.; Karasi, J-C.; Kayitenkore, K.; Kelleher, T.; Kitayaporn, D.; Kostrikis, L.G.; Kucherer, C.; Lara, C.; Leitner, T.; Liitsola, K.; Lingappa, J.; Linka, M.; Lorenzana de Rivera, I.; Lukashov, V.; Maayan, S.; Mayr, L.; McCutchan, F.; Meda, N.; Menu, E.; Mhalu, F.; Mloka, D.; Mokili, J.L.; Montes, B.; Mor, O.; Morgado, M.; Mosha, F.; Moussi, A.; Mullins, J.; Najera, R.; Nasr, M.; Ndembi, N.; Neilson, J.R.; Nerurkar, V.R.; Neuhann, F.; Nolte, C.; Novitsky, V.; Nyambi, P.; Ofner, M.; Paladin, F.J.; Papa, A.; Pape, J.; Parkin, N.; Parry, C.; Peeters, M.; Pelletier, A.; Pérez-Álvarez, L.; Pillay, D.; Pinto, A.; Quang, T.D.; Rademeyer, C.; Raikanikoda, F.; Rayfield, M.A.; Reynes, J-M.; Rinke de Wit, T.; Robbins, K.E.; Rolland, M.; Rousseau, C.; Salazar-Gonzales, J.; Salem, H.; Salminen, M.; Salomon, H.; Sandstrom, P.; Santiago, M.L.; Sarr, A.D.; Schroeder, B.; Segondy, M.; Selhorst, P.; Sempala, S.; Servais, J.; Shaik, A.; Shao, Y.; Slim, A.; Soares, M.A.; Songok, E.; Stewart, D.; Stokes, J.; Subbarao, S.; Sutthent, R.; Takehisa, J.; Tanuri, A.; Tee, K.K.; Thapa, K.; Thomson, M.; Tran, T.; Urassa, W.; Ushijima, H.; van de Perre, P.; van der Groen, G.; van Laethem, K.; van Oosterhout, J.; van Sighem, A.; van Wijngaerden, E.; Vandamme, A-M.; Vercauteren, J.; Vidal, N.; Wallace, L.; Williamson, C.; Wolday, D.; Xu, J.; Yang, C.; Zhang, L.; Zhang, R. Global and regional molecular epidemiology of HIV-1, 1990–2015: A systematic review, global survey, and trend analysis. Lancet Infect. Dis., 2019, 19(2), 143-155.
[http://dx.doi.org/10.1016/S1473-3099(18)30647-9] [PMID: 30509777]
[3]
NIH. What’s New in the Guidelines. Available from:https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/whats-new-guidelines (accessed Nov. 11, 2022)
[4]
Gulick, R.M.; Flexner, C. Long-acting HIV drugs for treatment and prevention. Annu. Rev. Med., 2019, 70(1), 137-150.
[http://dx.doi.org/10.1146/annurev-med-041217-013717] [PMID: 30355266]
[5]
Liang, G.; Zhang, Z.; Zhou, Y. Fostemsavir: A novel multidrug-resistant HIV-1 infection therapy. 2022. Available from:https://scholar.archive.org/work/bt26camiqrcnjc6rnplndqcycy/access/wayback/http://www.clausiuspress.com/conferences/LNMLS/BLSME%202022/Y0824.pdf (Accessed: Nov. 11, 2022)
[6]
Berruti, M.; Pincino, R.; Taramasso, L.; Di Biagio, A. Evaluating fostemsavir as a therapeutic option for patients with HIV. Expert Opin. Pharmacother., 2021, 22(12), 1539-1545.
[http://dx.doi.org/10.1080/14656566.2021.1937120] [PMID: 34125644]
[7]
Kozal, M.; Aberg, J.; Pialoux, G.; Cahn, P.; Thompson, M.; Molina, J.M.; Grinsztejn, B.; Diaz, R.; Castagna, A.; Kumar, P.; Latiff, G.; DeJesus, E.; Gummel, M.; Gartland, M.; Pierce, A.; Ackerman, P.; Llamoso, C.; Lataillade, M. Fostemsavir in adults with multidrug-resistant HIV-1 infection. N. Engl. J. Med., 2020, 382(13), 1232-1243.
[http://dx.doi.org/10.1056/NEJMoa1902493] [PMID: 32212519]
[8]
ViiV Healthcare and Medicine Patent Pool statement on voluntary licences in enabling access to fostemsavir. Available from:https://viivhealthcare.com/hiv-news-and-media/news/company-statements/fostemsavir-voluntary-licences-statement/ (accessed Oct. 18, 2022)
[9]
ViiV healthcare submits new drug application to the FDA for fostemsavir, an investigational, first-in-class attachment inhibitor for the treatment of HIV in adults with few treatment options available. Available from:https://viivhealthcare.com/en-us/media-center/news/press-releases/2019/december/viiv-healthcare-submits-new-drug-application-to-the-fda-for-fost/ (accessed Nov. 10, 2022)
[10]
ViiV Healthcare receives Marketing Authorisation for Rukobia (fostemsavir), a first-in-class attachment inhibitor in combination with other antiretrovirals for the treatment of adults with multidrug-resistant HIV. Available from:https://viivhealthcare.com/hiv-news-and-media/news/press-releases/2021/february/viiv-healthcare-receives-marketing-authorisation-for-rukobia/ (accessed Oct. 16, 2022)
[11]
ViiV Healthcare announces positive CHMP opinion for Rukobia (fostemsavir), a first-in-class attachment inhibitor for the treatment of adults with multidrug-resistant HIV with few treatment options available. Available from:https://viivhealthcare.com/hiv-news-and-media/news/press-releases/2020/december/viiv-healthcare-announces-positive-chmp-opinion-for-rukobia/ (accessed Oct. 18, 2022)
[12]
Craft, B.M.; Baker, D.E. Fostemsavir. Hosp. Pharm., 2021, (Jan)
[http://dx.doi.org/10.1177/0018578720985433]
[13]
Hiryak, K.; Koren, D.E. Fostemsavir: A novel attachment inhibitor for patients with multidrug-resistant HIV-1 infection. Ann. Pharmacother., 2021, 55(6), 792-797.
[http://dx.doi.org/10.1177/1060028020962424] [PMID: 32964736]
[14]
Magee, M.; Slater, J.; Mannino, F.; Ackerman, P.; Llamoso, C.; Moore, K. Effect of renal and hepatic impairment on the pharmacokinetics of temsavir, the active moiety of fostemsavir. J. Clin. Pharmacol., 2021, 61(7), 939-953.
[http://dx.doi.org/10.1002/jcph.1810] [PMID: 33368327]
[15]
NIH. Antiretroviral medication Fostemsavir (FTR, Rukobia). Available from:https://clinicalinfo.hiv.gov/en/guidelines/pediatric-arv/fostemsavir (accessed Nov. 11, 2022)
[16]
Seval, N.; Frank, C.; Kozal, M. Fostemsavir for the treatment of HIV. Expert Rev. Anti Infect. Ther., 2021, 19(8), 961-966.
[http://dx.doi.org/10.1080/14787210.2021.1865801] [PMID: 33331202]
[17]
Meanwell, N.A.; Krystal, M.R.; Nowicka-Sans, B.; Langley, D.R.; Conlon, D.A.; Eastgate, M.D.; Grasela, D.M.; Timmins, P.; Wang, T.; Kadow, J.F. Inhibitors of HIV-1 attachment: The discovery and development of temsavir and its prodrug fostemsavir. J. Med. Chem., 2018, 61(1), 62-80.
[http://dx.doi.org/10.1021/acs.jmedchem.7b01337] [PMID: 29271653]
[18]
Thompson, M.; Lalezari, J.P.; Kaplan, R.; Pinedo, Y.; Pena, O.A.S.; Cahn, P.; Stock, D.A.; Joshi, S.R.; Hanna, G.J.; Lataillade, M. Safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in antiretroviral-experienced subjects: Week 48 analysis of AI438011, a Phase IIb, randomized controlled trial. Antivir. Ther., 2017, 22(3), 215-223.
[http://dx.doi.org/10.3851/IMP3112] [PMID: 27922453]
[19]
Lataillade, M. Viral drug resistance through 48 Weeks, in a Phase 2b, randomized, controlled trial of the HIV-1 attachment inhibitor prodrug, fostemsavir. J. Acquir. Immune. Defic. Syndr., 2018, 77(3), 299-307.
[http://dx.doi.org/10.1097/QAI.0000000000001602]
[20]
Lalezari, J.P.; Latiff, G.H.; Brinson, C.; Echevarría, J.; Treviño-Pérez, S.; Bogner, J.R.; Thompson, M.; Fourie, J.; Sussmann Pena, O.A.; Mendo Urbina, F.C.; Martins, M.; Diaconescu, I.G.; Stock, D.A.; Joshi, S.R.; Hanna, G.J.; Lataillade, M. Safety and efficacy of the HIV-1 attachment inhibitor prodrug BMS-663068 in treatment-experienced individuals: 24 week results of AI438011, a phase 2b, randomised controlled trial. Lancet HIV, 2015, 2(10), e427-e437.
[http://dx.doi.org/10.1016/S2352-3018(15)00177-0] [PMID: 26423650]
[21]
Anderson, S.J.; Murray, M.; Cella, D.; Grossberg, R.; Hagins, D.; Towner, W.; Wang, M.; Clark, A.; Pierce, A.; Llamoso, C.; Ackerman, P.; Lataillade, M. Patient-reported outcomes in the phase III brighte trial of the HIV-1 attachment inhibitor prodrug fostemsavir in heavily treatment-experienced individuals. Patient, 2022, 15(1), 131-143.
[http://dx.doi.org/10.1007/s40271-021-00534-y] [PMID: 34180035]
[22]
Lataillade, M.; Lalezari, J.P.; Kozal, M.; Aberg, J.A.; Pialoux, G.; Cahn, P.; Thompson, M.; Molina, J.M.; Moreno, S.; Grinsztejn, B.; Diaz, R.S.; Castagna, A.; Kumar, P.N.; Latiff, G.H.; De Jesus, E.; Wang, M.; Chabria, S.; Gartland, M.; Pierce, A.; Ackerman, P.; Llamoso, C. Safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in heavily treatment-experienced individuals: Week 96 results of the phase 3 BRIGHTE study. Lancet HIV, 2020, 7(11), e740-e751.
[http://dx.doi.org/10.1016/S2352-3018(20)30240-X] [PMID: 33128903]
[23]
Chen, B. Molecular mechanism of HIV-1 entry. Trends Microbiol., 2019, 27(10), 878-891.
[http://dx.doi.org/10.1016/j.tim.2019.06.002] [PMID: 31262533]
[24]
German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’. Human Immunodeficiency Virus (HIV). Transfus. Med. Hemother., 2016, 43(3), 203-222.
[http://dx.doi.org/10.1159/000445852] [PMID: 27403093]
[25]
Pu, J.; Wang, Q.; Xu, W.; Lu, L.; Jiang, S. Development of protein- and peptide-based HIV entry inhibitors targeting gp120 or gp41. Viruses, 2019, 11(8), 705.
[http://dx.doi.org/10.3390/v11080705]
[26]
Sarkar, A. Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer. Nat. Commun., 2018, 9(1), 1-14.
[http://dx.doi.org/10.1038/s41467-018-04272-y]
[27]
Brelot, A.; Chakrabarti, L.A. CCR5 revisited: How mechanisms of HIV entry govern AIDS pathogenesis. J. Mol. Biol., 2018, 430(17), 2557-2589.
[http://dx.doi.org/10.1016/j.jmb.2018.06.027] [PMID: 29932942]
[28]
Gartland, M.; Cahn, P.; DeJesus, E.; Diaz, R.S.; Grossberg, R.; Kozal, M.; Kumar, P.; Molina, J.M.; Mendo Urbina, F.; Wang, M.; Du, F.; Chabria, S.; Clark, A.; Garside, L.; Krystal, M.; Mannino, F.; Pierce, A.; Ackerman, P.; Lataillade, M. Week 96 genotypic and phenotypic results of the fostemsavir phase 3 BRIGHTE study in heavily treatment-experienced adults living with multidrug-resistant HIV-1. Antimicrob. Agents Chemother., 2022, 66(6), e01751-21.
[http://dx.doi.org/10.1128/aac.01751-21] [PMID: 35502922]
[29]
Najjar, A.; Najjar, A.; Karaman, R. Newly developed prodrugs and prodrugs in development; an insight of the recent years. Molecules, 2020, 25(7), 884.
[http://dx.doi.org/10.3390/molecules25040884]
[30]
Gravatt, L.A.H.; Leibrand, C.R.; Patel, S.; McRae, M. New drugs in the pipeline for the treatment of HIV: A review. Curr. Infect. Dis. Reports, 2017, 19(11), 1-9.
[http://dx.doi.org/10.1007/s11908-017-0601-x]
[31]
NIH. Fostemsavir - Patient. Available from:https://clinicalinfo.hiv.gov/en/drugs/fostemsavir/patient (accessed Nov. 11, 2022)
[32]
Cahn, P.; Fink, V.; Patterson, P. Fostemsavir. Curr. Opin. HIV AIDS, 2018, 13(4), 341-345.
[http://dx.doi.org/10.1097/COH.0000000000000469] [PMID: 29771694]
[33]
Nettles, R.E.; Schürmann, D.; Zhu, L.; Stonier, M.; Huang, S.P.; Chang, I.; Chien, C.; Krystal, M.; Wind-Rotolo, M.; Ray, N.; Hanna, G.J.; Bertz, R.; Grasela, D. Pharmacodynamics, safety, and pharmacokinetics of BMS-663068, an oral HIV-1 attachment inhibitor in HIV-1-infected subjects. J. Infect. Dis., 2012, 206(7), 1002-1011.
[http://dx.doi.org/10.1093/infdis/jis432] [PMID: 22896665]
[34]
Highlights of prescribing information These highlights do not include all the information needed to use RUKOBIA safely and effectively. See full prescribing information for RUKOBIA. Available from:https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Rukobia/pdf/RUKOBIA-PI-PIL.PDF (Accessed: Aug. 27, 2023)
[35]
Lataillade, M.; Ackerman, P.; Schoofs, T.; Clark, A.; Kozal, M. Fostemsavir in heavily treatment-experienced individuals living with HIV-1: Insights from the phase 3 brighte study. J. AIDS HIV Treat., 2021, 3(2), 31-36.
[http://dx.doi.org/10.33696/AIDS.3.019]
[36]
Fostemsavir tromethamine. Am. J. Health Syst. Pharm., 2020, 77(23), 1924-1927.
[http://dx.doi.org/10.1093/ajhp/zxaa294] [PMID: 32936234]
[37]
Prévost, J. Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir. bioRxiv, 2023, 2023, 537181.
[http://dx.doi.org/10.1101/2023.04.17.537181]
[38]
Gartland, M.; Zhou, N.; Stewart, E.; Pierce, A.; Clark, A.; Ackerman, P.; Llamoso, C.; Lataillade, M.; Krystal, M. Susceptibility of global HIV-1 clinical isolates to fostemsavir using the PhenoSense® Entry assay. J. Antimicrob. Chemother., 2021, 76(3), 648-652.
[http://dx.doi.org/10.1093/jac/dkaa474] [PMID: 33241285]
[39]
Lai, Y.T. Small molecule HIV-1 attachment inhibitors: Discovery, mode of action and structural basis of inhibition. Viruses, 2021, 13(5), 843.
[http://dx.doi.org/10.3390/v13050843]

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    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59825898 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59825898) limit 1
      41.56msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 59825898
      • 1: 59825898
      • 2: 59825898
      • 3: 59825898
      • 4: 59825898
      • 5: 59825898
      • 6: 59825898
      • 7: 59825898
      • 8: 59825898
      • 9: 59825898
      • 10: 59825898
      • 11: 59825898
      • 12: 59825898
      • 13: 59825898
      • 14: 59825898
      • 15: 59825898
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=135486
      8.6msalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 213 limit 1
      470μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 213
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=213) and sj.journal_id!=213 group by `j`.`nid`) as `aggregate_table`
      1.41msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=213) and sj.journal_id!=213 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      7.26msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=213) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      148msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=213) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      174msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '135486'
      390μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 135486
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '135486'
      12.16msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 135486
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '135486' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      19.66msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 135486
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      380μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      710μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 213 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      128msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 213 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      29.28msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 213 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      1.67msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 135486 limit 1
      300μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 135486
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 135486 and content_type = 'article' order by status desc limit 1
      400μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 222558 limit 1
      330μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 222558
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      380μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CIS' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      2.63msalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CIS
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '135486' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      560μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '12232' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      490μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3282' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      460μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '1' and is_uploaded = 1 and issue_id = 12232 order by cast(first_page as SIGNED) desc limit 1
      1.13msalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 1
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '8' and is_uploaded = 1 and issue_id = 12232 order by cast(first_page as SIGNED) asc limit 1
      1.09msalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 8
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      250μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      310μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 135486 limit 1
      3.89msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 135486
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 213 and `b`.`banner_from_date` <= 1740774257 and `b`.`banner_to_date` >= 1740774257 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.57msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 213
      • 3: 1740774257
      • 4: 1740774257
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 213 and `b`.`banner_from_date` <= 1740774258 and `b`.`banner_to_date` >= 1740774258 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.59msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 213
      • 3: 1740774258
      • 4: 1740774258
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='9d427a6bbdc0c85a0849702fdc5dc211'
      320μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:291
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-28 20:24:18GET/article/135486514331