Abstract
Ethnopharmacological relevance: Mesua ferrea Linn. belonging to family Guttiferae. The plant widely grows in the hills and is planted in gardens in many parts of India. It is cultivated as an ornamental plant because of its graceful shape, pink to red hanging leaves and enormous wonderful, fragrant white blossoms. The current review summarizes different significant, fundamental and medicinal properties of this Indian therapeutic herb. It is known to be an evergreen tree 20-30 m in height. Along with its elaborate utilization, entire plant has different therapeutic values in the conventional system of drugs. The main aim of this review is to provide a brief overview of the pharmacological, phytochemical, pharmacognostic, ethanomedical and toxicological studies of M. ferrea. A comprehensive review of the literature was conducted using multiple search sites such as PubMed, Google Scholar, Springer, and Science Direct, Scopus, Web of Science, SciFinder, etc. Other literary sources include Wikipedia, ethnobotanical books, and botanical journals. Numerous phytochemicals have been discovered and isolated from Mesua ferrea plant parts which include xanthones, terpenoids, sterol, β-amyrin, β-sitosterol, mesuaferrol, mesuaferrin-A, mesuaferrin B, caloxanthone C,1,8-dihydro-3-methoxy-6- methylanthraquinone, friedelin, fats, flavanoids and betulinic acid. All of the documented pharmacological activities, such as antioxidant and antibacterial activity, antiarthritic, antiinflammatory, antivenom, antiulcerogenic, anticonvulsant, wound healing, depressant, analgesic are due to the presence of certain phytochemical substances. This review mainly targets the botanical aspects of Mesua ferrea along with their phytochemical constituents, ethnomedicinal use, different pharmacological activity, and future possibilities. Mesua ferrea is very important in the traditional Indian system. More research is needed to uncover important features of Mesua ferrea in medical practice.