Comparison of Imaging Characteristics of Gangliogliomas between
Child/Adolescent Group and Adult Group

Xuan      Zheng; Quan      Huang; Shao-Lei      Guo; Meng-Sha      Zou; Hui      Zhu; Shi-Ting      Li

doi:10.2174/1573405620666230906092212

Abstract

Background: Ganglioglioma is a rare, slowly proliferating mixed glioneuronal tumor, with the highest incidence observed in children and young adults, but it can also occur in adults.

Objective: This study aimed to compare the imaging characteristics of ganglioglioma in children/adolescents and adults to facilitate radiographic diagnosis.

Methods: In this retrospective study, a total of 32 patients were included and divided into two groups: the child/adolescent group (age < 18 years, n=19) and the adult group (age ≥ 18 years, n=13). Various variables were analyzed, including maximum diameter, location, periphery, border, calcification, unenhanced CT attenuation, T1WI, T2WI/FLAIR, and DWI signal intensity, enhancement pattern, degree of enhancement, homogeneity of enhancement, solid/cystic component, peri-tumoral edema, intra-tumoral septa, peri-tumoral capsule, and intra-tumoral hemorrhage.

Results: Most gangliogliomas were situated in the peripheral regions, particularly in the temporal lobe. The majority exhibited hypointense/isointense signals on T1WI and hyperintense signals on T2WI/FLAIR and DWI, with predominantly heterogeneous nodular enhancement. Peri-tumoral edema was significantly less frequent in the child/adolescent group, while marked enhancement was significantly more common in the adult group. There was no significant difference in maximum diameter between the child/adolescent group and the adult group.

Conclusion: Peri-tumoral edema was significantly less prevalent in the child/adolescent group, whereas marked enhancement was significantly more frequent in the adult group. To ensure accurate results, a larger case series should be conducted to validate our findings.

[1]
Zentner J, Hufnagel A, Wolf HK, et al. Surgical treatment of neoplasms associated with medically intractable epilepsy. Neurosurgery  1997; 41(2): 378-87.
 [http://dx.doi.org/10.1097/00006123-199708000-00008] [PMID: 9257305]

[2]
Luyken C, Blümcke I, Fimmers R, Urbach H, Wiestler OD, Schramm J. Supratentorial gangliogliomas: Histopathologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years. Cancer  2004; 101(1): 146-55.
 [http://dx.doi.org/10.1002/cncr.20332] [PMID: 15222000]

[3]
Louis DN, Perry A, Wesseling P, et al. The 2021 WHO classification of tumors of the central nervous system: A summary. Neuroncol  2021; 23(8): 1231-51.
 [http://dx.doi.org/10.1093/neuonc/noab106] [PMID: 34185076]

[4]
Compton JJ, Issa Laack NN, Eckel LJ, Schomas DA, Giannini C, Meyer FB. Long-term outcomes for low-grade intracranial ganglioglioma: 30-year experience from the Mayo Clinic. J Neurosurg  2012; 117(5): 825-30.
 [http://dx.doi.org/10.3171/2012.7.JNS111260] [PMID: 22957524]

[5]
Alturkustani M. Classification of pediatric gangliogliomas based on the histological infiltration. Curr Oncol  2022; 29(10): 6764-75.
 [http://dx.doi.org/10.3390/curroncol29100532] [PMID: 36290809]

[6]
Pan C, Chen X, Xu C, et al. Brainstem gangliogliomas: Prognostic factors, surgical indications and functional outcomes. J Neurooncol  2016; 128(3): 445-53.
 [http://dx.doi.org/10.1007/s11060-016-2131-z] [PMID: 27112924]

[7]
Dang H, Khan AB, Gadgil N, et al. Primary spinal intramedullary anaplastic ganglioglioma in a pediatric patient. Surg Neurol Int  2023; 14: 55.
 [http://dx.doi.org/10.25259/SNI_825_2022] [PMID: 36895253]

[8]
Southwell DG, Garcia PA, Berger MS, Barbaro NM, Chang EF. Long-term seizure control outcomes after resection of gangliogliomas. Neurosurgery  2012; 70(6): 1406-14.
 [http://dx.doi.org/10.1227/NEU.0b013e3182500a4c] [PMID: 22353798]

[9]
Bel U, Ellison DW, Shulkin BL, et al. Infiltrative cerebellar ganglioglioma: Conventional and advanced MRI, proton MR spectroscopic, and FDG PET findings in an 18-month-old child. Clin Radiol  2011; 66(2): 194-201.

[10]
Koeller KK, Henry JM. From the archives of the AFIP. Radiographics  2001; 21(6): 1533-56.
 [http://dx.doi.org/10.1148/radiographics.21.6.g01nv051533] [PMID: 11706224]

[11]
Phi JH, Paeng JC, Lee HS, et al. Evaluation of focal cortical dysplasia and mixed neuronal and glial tumors in pediatric epilepsy patients using 18F-FDG and 11C-methionine pet. J Nucl Med  2010; 51(5): 728-34.
 [http://dx.doi.org/10.2967/jnumed.109.070920] [PMID: 20395328]

[12]
Gao L, Han F, Jin Y, et al. Imaging features of rosette-forming glioneuronal tumours. Clin Radiol  2018; 73(3): 275-82.
 [http://dx.doi.org/10.1016/j.crad.2017.10.011] [PMID: 29146003]

[13]
Provenzale JM, Ali U, Barboriak DP, Kallmes DF, Delong DM, McLendon RE. Comparison of patient age with MR imaging features of gangliogliomas. AJR Am J Roentgenol  2000; 174(3): 859-62.
 [http://dx.doi.org/10.2214/ajr.174.3.1740859] [PMID: 10701639]

[14]
Louis DN, Perry A, Reifenberger G, et al. The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol  2016; 131(6): 803-20.
 [http://dx.doi.org/10.1007/s00401-016-1545-1] [PMID: 27157931]

[15]
Johnson JH Jr, Hariharan S, Berman J, et al. Clinical outcome of pediatric gangliogliomas: Ninety-nine cases over 20 years. Pediatr Neurosurg  1997; 27(4): 203-7.
 [http://dx.doi.org/10.1159/000121252] [PMID: 9577974]

[16]
Wallace D, Ruban D, Kanner A, et al. Temporal lobe gangliogliomas associated with chronic epilepsy: Long-term surgical outcomes. Clin Neurol Neurosurg  2013; 115(4): 472-6.
 [http://dx.doi.org/10.1016/j.clineuro.2012.05.034] [PMID: 22727209]

[17]
Jorge CL, Nagahashi-Marie SK, Pedreira CC, et al. Clinical characteristics and surgical outcome of patients with temporal lobe tumors and epilepsy. Arq Neuropsiquiatr  2000; 58(4): 1002-8.
 [http://dx.doi.org/10.1590/S0004-282X2000000600004] [PMID: 11105064]

[18]
Morris HH, Matkovic Z, Estes ML, et al. Ganglioglioma and intractable epilepsy: Clinical and neurophysiologic features and predictors of outcome after surgery. Epilepsia  1998; 39(3): 307-13.
 [http://dx.doi.org/10.1111/j.1528-1157.1998.tb01378.x] [PMID: 9578050]

[19]
Krouwer HGJ, Davis RL, McDermott MW, Hoshino T, Prados MD. Gangliogliomas: A clinicopathological study of 25 cases and review of the literature. J Neurooncol  1993; 17(2): 139-54.
 [http://dx.doi.org/10.1007/BF01050216] [PMID: 8145057]

[20]
Gelebert-Gonzalez M, Serramito-Garcia R. The role of postoperative radiotherapy for the treatment of gangliogliomas. Cancer  2010; 116(12): 3071.
 [http://dx.doi.org/10.1002/cncr.25272] [PMID: 20564414]

[21]
Kincaid PK, El-Saden SM, Park SH, Goy BW. Cerebral gangliogliomas: Preoperative grading using FDG-PET and 201Tl-SPECT. AJNR Am J Neuroradiol  1998; 19(5): 801-6.
 [PMID: 9613489]

[22]
Selvanathan SK, Hammouche S, Salminen HJ, Jenkinson MD. Outcome and prognostic features in anaplastic ganglioglioma: Analysis of cases from the SEER database. J Neurooncol  2011; 105(3): 539-45.
 [http://dx.doi.org/10.1007/s11060-011-0615-4] [PMID: 21626070]

[23]
Provenzale JM, Arata MA, Turkington TG, McLendon RE, Coleman RE. Gangliogliomas: Characterization by registered positron emission tomography-MR images. AJR Am J Roentgenol  1999; 172(4): 1103-7.
 [http://dx.doi.org/10.2214/ajr.172.4.10587156] [PMID: 10587156]

[24]
Zentner J, Wolf HK, Ostertun B, et al. Gangliogliomas: Clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatry  1994; 57(12): 1497-502.
 [http://dx.doi.org/10.1136/jnnp.57.12.1497] [PMID: 7798980]

[25]
Zhang S, Ai L, Chen XZ, Wang K. Radiological evaluation of infratentorial gangliogliomas in various anatomic locations of the cerebellum and brainstem. Clin Neuroradiol  2017; 27(3): 319-27.
 [http://dx.doi.org/10.1007/s00062-015-0495-7] [PMID: 26744304]

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DOI https://dx.doi.org/10.2174/1573405620666230906092212	Print ISSN 1573-4056
Publisher Name Bentham Science Publisher	Online ISSN 1875-6603

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Comparison of Imaging Characteristics of Gangliogliomas between Child/Adolescent Group and Adult Group

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