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Coronaviruses

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ISSN (Print): 2666-7967
ISSN (Online): 2666-7975

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Letter Article

Investigation of Reported Anaphylaxis Post COVID-19 Vaccination in Subjects with History of Allergies and Anaphylaxis

Author(s): Aditya P. Desai*, Aryan P. Desai, Victoria S. Ochs and Prashant V. Desai

Volume 4, Issue 3, 2023

Published on: 05 October, 2023

Article ID: e040923220691 Pages: 5

DOI: 10.2174/2666796704666230904150831

Price: $65

Abstract

Background: Two mRNA COVID-19 vaccines, Pfizer-BioNTech and Moderna, are currently approved in the United States, and one viral-vector vaccine, J&J/Janssen, is authorized for limited use. The Vaccine Adverse Event Reporting System (VAERS) database gathers reports of adverse effects, including anaphylaxis.

Objective: In this manuscript, we provide a summary of reported incidence of anaphylaxis rates following administration of the two mRNA and one viral-vector COVID-19 vaccine.

Methods: A detailed investigation of the relative risk of anaphylaxis for recipients with or without a prior history of allergy and/or anaphylaxis is also described.

Results: Overall reported incidence of anaphylaxis is 4.49 [95% CI: 0.25 – 8.73] cases per million doses administered.

Conclusion: The reported risk of anaphylaxis is 1.83 times greater for recipients with prior allergies and no anaphylaxis but 17.70 times greater for recipients with prior allergies and anaphylaxis.

Graphical Abstract

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