Generic placeholder image

Current Women`s Health Reviews

Editor-in-Chief

ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

Research Article

Risk Factors Associated with Cervical Cancer: A Matched Case-control Study

Author(s): Mansoureh Refaei, Zahra Cheraghi, Farzaneh Soltani and Batoul Khodakarami*

Volume 20, Issue 5, 2024

Published on: 19 September, 2023

Article ID: e310723219291 Pages: 7

DOI: 10.2174/1573404820666230731125500

Price: $65

Abstract

Background: One of the most effective ways to prevent cervical cancer is to identify the risk factors for the disease.

Objective: The purpose of this research was to determine the risk factors for cervical cancer in women in Iran.

Methods: This was a matched case-control study. 105 participants (35 patients with cervical cancer and 70 healthy women) were selected from the registered patients and women attending a women’s specialized hospital in Hamadan, Iran. One case was matched to 2 controls by age (±3 years). Demographic and clinical data were collected using a semi-structured questionnaire. Conditional multivariate logistic regression model and STATA 11 software were used for data analysis.

Results: The mean age of women in the case and control group were 58.02(12.32) and 58.11(12.25) years (p = 0.486), respectively. Patients had lower education levels (p = 0.037), lower economic status (p˂0.001), and lower spouse education levels (p = 0.009). The results showed OCP users were 8.79 times more likely to develop cervical cancer than women who do not use OCP (p = 0.007), and the probability of cervical cancer in women increased by 8.33 times (<0.001) with decreasing each level of socio-economic status.

Conclusion: The results of the present study showed low economic status, and a history of using oral contraceptive pills are risk factors for cervical cancer.

Graphical Abstract

[1]
Berek, J.S. Berek & Novak's Gynecology, 16th ed.; Lippincott Williams & Wilkins (LWW):Philadelphia; , 2019.
[2]
Cervical cancer; World Health Organization, 2022.
[3]
Farhood, B.; Raei, B.; Malekzadeh, R.; Shirvani, M.; Najafi, M.; Mortezazadeh, T. A review of incidence and mortality of colorectal, lung, liver, thyroid, and bladder cancers in Iran and compared to other countries. Contemp. Oncol., 2019, 23(1), 7-15.
[http://dx.doi.org/10.5114/wo.2019.84112] [PMID: 31061631]
[4]
Babazadeh, M.; Pourali, L.; Attaran, N.; Nikfarjam, Z.; Masoudi, T.; Salehi, M. Demographic survey of 600 patients with gynecologic cancers in Mashhad, Iran in 1985-2012. Iran J. Obstet. Gynecol., 2016, 19(3), 1-8.
[http://dx.doi.org/10.22038/ijogi.2016.6863]
[5]
Fernandes, A.; Viveros-Carreñٌo, D.; Hoegl, J.; Ávila, M.; Pareja, R. Human papillomavirus-independent cervical cancer. Int. J. Gynecol. Cancer, 2022, 32(1), 1-7.
[http://dx.doi.org/10.1136/ijgc-2021-003014] [PMID: 34725203]
[6]
Kombe Kombe, A.J.; Li, B.; Zahid, A.; Mengist, H.M.; Bounda, G.A.; Zhou, Y.; Jin, T. Epidemiology and burden of human papillomavirus and related diseases, molecular pathogenesis, and vaccine evaluation. Front. Public Health, 2021, 8552028.
[http://dx.doi.org/10.3389/fpubh.2020.552028] [PMID: 33553082]
[7]
Jamdar, F.; Farzaneh, F.; Navidpour, F.; Younesi, S.; Balvayeh, P.; Hosseini, M.; Ghodssi-Ghasemabadi, R. Prevalence of human papillomavirus infection among Iranian women using COBAS HPV DNA testing. Infect. Agent. Cancer, 2018, 13(1), 6.
[http://dx.doi.org/10.1186/s13027-018-0178-5] [PMID: 29416557]
[8]
Morowatisharifabad, M.A.; Norouzi, S.; Layeghy, S.; Norouzi, A. Survey of cervix cancer screening determinants among 20-65 years old women based on health belief model in lordegan, Chahar Mahal Bakhtiyaree, 2009. Tolooebehdasht., 2018, 12(1), 98-106.
[9]
Stewart, T.S.; Moodley, J.; Walter, F.M. Population risk factors for late-stage presentation of cervical cancer in sub-Saharan Africa. Cancer Epidemiol., 2018, 53, 81-92.
[http://dx.doi.org/10.1016/j.canep.2018.01.014] [PMID: 29414636]
[10]
Beyene, T.; Akibu, M.; Bekele, H.; Seyoum, W. Risk factors for precancerous cervical lesion among women screened for cervical cancer in south Ethiopia: Unmatched case-control study. PLoS One, 2021, 16(7), e0254663.
[http://dx.doi.org/10.1371/journal.pone.0254663] [PMID: 34265004]
[11]
Zhang, S.; Xu, H.; Zhang, L.; Qiao, Y. Cervical cancer: Epidemiology, risk factors and screening. Chin. J. Cancer Res., 2020, 32(6), 720-728.
[http://dx.doi.org/10.21147/j.issn.1000-9604.2020.06.05] [PMID: 33446995]
[12]
Kashyap, N.; Krishnan, N.; Kaur, S.; Ghai, S. Risk factors of cervical Cancer: A case-control study. Asia Pac. J. Oncol. Nurs., 2019, 6(3), 308-314.
[http://dx.doi.org/10.4103/apjon.apjon_73_18] [PMID: 31259228]
[13]
Delam, H.; Izanloo, S.; Bazrafshan, M-R.; Eidi, A. Risk factors for cervical cancer: An epidemiological review. J. Health. Sci. Surveill. Syst., 2020, 8(3), 105-109.
[14]
Krings, A.; Dunyo, P.; Pesic, A.; Tetteh, S.; Hansen, B.; Gedzah, I.; Wormenor, C.M.; Amuah, J.E.; Behnke, A.L.; Höِfler, D.; Pawlita, M.; Kaufmann, A.M. Characterization of human papillomavirus prevalence and risk factors to guide cervical cancer screening in the north tongu district, Ghana. PLoS One., 2019, 14(6), e0218762.
[http://dx.doi.org/10.1371/journal.pone.0218762] [PMID: 31246997]
[15]
Zhao, M.; Gu, R.; Ding, S.; Luo, L.; Jia, Y.; Gao, C.; Chen, B.; Xu, X.; Chen, H. Risk factors of cervical cancer among ethnic minorities in Yunnan Province, China: A case–control study. Eur. J. Cancer Prev., 2022, 31(3), 287-292.
[http://dx.doi.org/10.1097/CEJ.0000000000000704] [PMID: 34267110]
[16]
Liu, L.Y.; Wang, F.; Cui, S.D.; Tian, F.G.; Fan, Z.M.; Geng, C.Z.; Cao, X.C.; Yang, Z.L.; Wang, X.; Liang, H.; Wang, S.; Jiang, H.C.; Duan, X.N.; Wang, H.B.; Li, G.L.; Wang, Q.T.; Zhang, J.G.; Jin, F.; Tang, J.H.; Li, L.; Zhu, S.G.; Zuo, W.S.; Yu, L.X.; Xiang, Y.J.; Zhou, F.; Li, L.; Zhang, Q.; Fu, Q.Y.; Ma, Z.B.; Gao, D.Z.; Li, Y.Y.; Liu, L.; Ye, C.M.; Wang, Y.J.; Zhou, W.Z.; Yu, Z.G. A case-control study on risk factors of breast cancer in Han Chinese women. Oncotarget, 2017, 8(57), 97217-97230.
[http://dx.doi.org/10.18632/oncotarget.21743] [PMID: 29228605]
[17]
Marzieh, N.; Modares, M.; Erfani, A.; Mozafari, N. The study of frequency of risk factors of cervical cancer among women attending general hospitals in Tehran, 2005-2006. Iran. J. Med. Sci., 2007, 14(56), 189-195.
[18]
Karimi Zarchi, M.; Akhavan, A.; Gholami, H.; Dehghani, A.; Naghshi, M.; Mohseni, F. Evaluation of cervical cancer risk-factors in women referred to Yazd-Iran hospitals from 2002 to 2009. Asian Pac. J. Cancer Prev., 2010, 11(2), 537-538.
[PMID: 20843147]
[19]
Dilley, S.; Powell, T.C.; Bae, S.; Straughn, J.M.; Leath, C.A.; Kim, K.H. Racial, Geographic and socioeconomic risk factors for development of advanced stage cervical cancer. Obstet. Gynecol., 2017, 129(1), 106S.
[http://dx.doi.org/10.1097/01.AOG.0000514990.39187.95]
[20]
Aliakbar, T.; Eshrat, F. Study of Effective Factors in Cervical Cancer in Isfahan. J. Guilan Univ. Med. Sci., 2001, 10, 6-12.
[21]
Jafari, S.M.; Chapari, I.A. Role of demographic and socioeconomic factors in cervical Cancer. Majallah-i Zanan, Mamai va Nazai-i Iran, 2011, 13(6), 22-31.
[http://dx.doi.org/10.22038/ijogi.2011.5799]
[22]
Moss, J.L.; Liu, B.; Feuer, E. J. Urban/rural differences in breast and cervical cancer incidence: the mediating roles of socioeconomic status and provider density. Womens Health Issues, 2017, 27(6), 683-691.
[http://dx.doi.org/10.1016/j.whi.2017.09.008] [PMID: 29108988]
[23]
Shayan, A.; Ahmadinia, H.; Rabiee, S.; Niksiar, S.; Khodakarami, B. Investigating the survival rate in women with breast cancer in Iran. J. Res. Med. Dent. Sci., 2020, 8(2), 49-55.
[24]
Sharma, P.; Pattanshetty, S.M. A study on risk factors of cervical cancer among patients attending a tertiary care hospital: A case-control study. Clin. Epidemiol. Glob. Health, 2018, 6(2), 83-87.
[http://dx.doi.org/10.1016/j.cegh.2017.10.001]
[25]
Vaisy, A.; Lotfinejad, S.; Zhian, F. Risk of cancer with combined oral contraceptive use among Iranian women. Asian Pac. J. Cancer Prev., 2014, 15(14), 5517-5522.
[http://dx.doi.org/10.7314/APJCP.2014.15.14.5517] [PMID: 25081657]
[26]
Paul, E.N.J.; Henri, E.; Valere, M.K.; Sara, S.; Emil, M. Risk factors of cervical cancer in two reference hospitals of douala: A case-control study. Cancer Sci Res., 2020, 3(1), 1-6.
[27]
Iversen, L.; Sivasubramaniam, S.; Lee, A.J.; Fielding, S.; Hannaford, P.C. Lifetime cancer risk and combined oral contraceptives: The royal college of general practitioners’ oral contraception study. Am. J. Obstet. Gynecol., 2017, 216(6), 580.e1-580.e9.
[http://dx.doi.org/10.1016/j.ajog.2017.02.002]
[28]
Peng, Y.; Wang, X.; Feng, H.; Yan, G. Is oral contraceptive use associated with an increased risk of cervical cancer? An evidence-based meta-analysis. J. Obstet. Gynaecol. Res., 2017, 43(5), 913-922.
[http://dx.doi.org/10.1111/jog.13291] [PMID: 28759170]
[29]
Mogren, I.; Stenlund, H.; Hِögberg, U. Long-term impact of reproductive factors on the risk of cervical, endometrial, ovarian and breast cancer. Acta Oncol., 2001, 40(7), 849-854.
[http://dx.doi.org/10.1080/02841860152703481] [PMID: 11859985]
[30]
Bayo, S.; Bosch, F.X.; de Sanjosé, S.; Muٌñٌoz, N.; Combita, A.L.; Coursaget, P.; Diaz, M.; Dolo, A.; van den Brule, A.J.C.; Meijer, C.J.M. Risk factors of invasive cervical cancer in Mali. Int. J. Epidemiol., 2002, 31(1), 202-209.
[http://dx.doi.org/10.1093/ije/31.1.202] [PMID: 11914322]
[31]
World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA, 2013, 310(20), 2191-2194.
[http://dx.doi.org/10.1001/jama.2013.281053] [PMID: 24141714]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy