Login Register Cart 0
Generic placeholder image

Current Bioactive Compounds

Editor-in-Chief

ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

Phytochemical and Pharmacological Potential of Ferula asafetida “Hing”

Author(s): Sonia Singh*, Arpit Shukla and Bhupesh C. Semwal

Volume 20, Issue 3, 2024

Published on: 13 July, 2023

Article ID: e260623218247 Pages: 17

DOI: 10.2174/1573407219666230626111830

Price: $65

Abstract

Asafoetida, also known as Hing, is a resinous gum derived from the roots of Ferula species, specifically Ferula asafetida. From ancient times, it has been employed both in the kitchen as a seasoning and in the practice of traditional medicine. In terms of pharmacognosy, asafoetida is comprised of a number of active chemicals, the most notable of which are coumarins, volatile oils (17%), and ferulic acid (60%). Ferulic acid and coumarins (40%) are two of the components that contribute to the medicinal value of this plant. The volatile oils are responsible for the strong odour and flavour of this plant. It is used for a variety of applications in the medical field. It is not only used as spices and condiments for the goal of imparting taste in curries, but it is also utilised in the treatment of gastrointestinal tract diseases, asthma, whooping cough, hypertension, and a variety of other conditions. The herb has been used to extract a variety of phytochemical components, including sesquiterpene coumarins, coumarins, diterpene coumarins, and chemicals containing sulphur. This manuscript provides a synopsis of the facts concerning the pharmacological activities and bioactive components of Ferula asafetida.

Graphical Abstract

[1]
Nur Manik, M.I.; Ali, M.H.; Nath Ray, M.; Islam, M.M.; Zobayed, A.; Hossain, M.T.; Md, A.; Fahad, T.M.; Khan, A. A comprehensive review on medicinal values and health benefits of spices and condiments commonly used in the Indian sub-continent. Res. J. Pharmacogn. Phytochem., 2022, 14(1), 11-18.
[http://dx.doi.org/10.52711/0975-4385.2022.00003]
[2]
Srinivasan, K. Role of spices beyond food flavoring: Nutraceuticals with multiple health effects. Food Rev. Int., 2005, 21(2), 167-188.
[http://dx.doi.org/10.1081/FRI-200051872]
[3]
Srinivasan, K. Spices for Taste and Flavour: Nutraceuticals for Human Health. CSIR, 2011.
[4]
Srinivasan, K. Dietary spices as beneficial modulators of lipid profile in conditions of metabolic disorders and diseases. Food Funct., 2013, 4(4), 503-521.
[http://dx.doi.org/10.1039/c2fo30249g] [PMID: 23364205]
[5]
Sahebkar, A.; Iranshahi, M. Biological activities of essential oils from the genus Ferula (Apiaceae). Asian Biomed., 2010, 4(6), 835-847.
[http://dx.doi.org/10.2478/abm-2010-0110]
[6]
Shahrajabian, M.H.; Sun, W.; Soleymani, A.; Khoshkaram, M.; Cheng, Q. Asafoetida, God’s food, a natural medicine. Pharmacogn. Commun., 2021, 11(1), 36-39.
[http://dx.doi.org/10.5530/pc.2021.1.8]
[7]
Duan, H.; Takaishi, Y.; Tori, M.; Takaoka, S.; Honda, G.; Ito, M.; Takeda, Y.; Kodzhimatov, O.K.; Kodzhimatov, K.; Ashurmetov, O. Polysulfide derivatives from Ferula foetida. J. Nat. Prod., 2002, 65(11), 1667-1669.
[http://dx.doi.org/10.1021/np010541h] [PMID: 12444696]
[8]
Rajanikanth, B.; Ravindranath, B.; Shankaranarayana, M.L. Volatile polysulphides of asafoetida. Phytochemistry, 1984, 23(4), 899-900.
[http://dx.doi.org/10.1016/S0031-9422(00)85054-2]
[9]
Takeoka, G. Instrumental analysis of food Flavors-4 volatile constituents of asafoetida. ACS Symposium Series; American Chemical Society.: Washington, 1974, pp. 33-44.
[10]
Evans, W.C.; Trease, G.E. Volatile oils and resins. Trease and Evans Pharmacognosy; Elsevier: Amsterdam, 2002, pp. 253-288.
[11]
Tyler, V.E.; Brady, L.R.; Robbers, J.E. Pharmacognosy; Lea and Febiger: Philadelphia, 1976.
[12]
Choudhary, S.; Kaurav, H.; Chaudhary, G. Hing (Ferula Asafoetida). A review based upon its ayurvedic and pharmacological properties. Int. J. Pharm. Sci. Rev. Res., 2021, 68(2)
[http://dx.doi.org/10.47583/ijpsrr.2021.v68i02.006]
[13]
Lee, C.L.; Chiang, L.C.; Cheng, L.H.; Liaw, C.C.; Abd El-Razek, M.H.; Chang, F.R.; Wu, Y.C.; Influenza, A. H1N1) antiviral and cytotoxic agents from Ferula assa-foetida. J. Nat. Prod., 2009, 72(9), 1568-1572.
[http://dx.doi.org/10.1021/np900158f] [PMID: 19691312]
[14]
Dehpour, AA; Ebrahimzadeh, MA; Fazel, NS 2009, Antioxidant activity of the methanol extract of Ferula asafoetida and its essential oil composition. Grasas y Aceites, 60(4), 405-412.
[15]
Angelini, P.; Pagiotti, R.; Venanzoni, R.; Granetti, B. Antifungal and allelopathic effects of Asafoetida against Trichoderma harzianum and Pleurotus spp. Allelopathy J., 2009, 23(2), 357-368.
[16]
Aruna, K.; Sivaramakrishnan, V.M. Anticarcinogenic effects of some Indian plant products. Food Chem. Toxicol., 1992, 30(11), 953-956.
[http://dx.doi.org/10.1016/0278-6915(92)90180-S] [PMID: 1473788]
[17]
Abu-Zaiton, A.S. Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pak. J. Biol. Sci., 2010, 13(2), 97-100.
[http://dx.doi.org/10.3923/pjbs.2010.97.100] [PMID: 20415145]
[18]
Kumar, P.; Singh, D.K. Molluscicidal activity of Ferula asafoetida, Syzygium aromaticum and Carum carvi and their active components against the snail Lymnaea acuminata. Chemosphere, 2006, 63(9), 1568-1574.
[http://dx.doi.org/10.1016/j.chemosphere.2005.08.071] [PMID: 16310827]
[19]
Khajeh, M.; Yamini, Y.; Bahramifar, N.; Sefidkon, F.; Reza Pirmoradei, M. Comparison of essential oils compositions of Ferula assa-foetida obtained by supercritical carbon dioxide extraction and hydrodistillation methods. Food Chem., 2005, 91(4), 639-644.
[http://dx.doi.org/10.1016/j.foodchem.2004.06.033]
[20]
Saleem, M.; Alam, A.; Sultana, S. Asafoetida inhibits early events of carcinogenesis. Life Sci., 2001, 68(16), 1913-1921.
[http://dx.doi.org/10.1016/S0024-3205(01)00977-8] [PMID: 11292069]
[21]
Kavoosi, G.; Rowshan, V. Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula assa-foetida oleo-gum-resin: Effect of collection time. Food Chem., 2013, 138(4), 2180-2187.
[http://dx.doi.org/10.1016/j.foodchem.2012.11.131] [PMID: 23497874]
[22]
Shrivastava, V.; Bhardwaj, U.; Sharma, V.; Mahajan, N.; Sharma, V.; Shrivastava, G. Antimicrobial activities of Asafoetida resin extracts (a potential Indian spice). J. Pharm. Res., 2012, 5(10), 5022-5024.
[23]
Divya, K.; Ramalakshmi, K.; Murthy, P.S.; Jagan Mohan Rao, L. Volatile oils from Ferula asafoetida varieties and their antimicrobial activity. Lebensm. Wiss. Technol., 2014, 59(2), 774-779.
[http://dx.doi.org/10.1016/j.lwt.2014.07.013]
[24]
Padhye, S.; Rai, S.; Lamba, N.N.; Upadhyay, M. Spices as potent antibacterial agents against Staphylococcus aureus. J. Sci. Technol., 2014, 4(1), 46-51.
[25]
Patil, S.D.; Shinde, S.; Kandpile, P.; Jain, A.S. Evaluation of antimicrobial activity of asafoetida. Int. J. Pharm. Sci. Res., 2015, 6(2), 722.
[26]
Bhatnager, R; Rani, R; Dang, AS Antibacterial activity of Ferula asafoetida: A comparison of red and white type. J. App. Biol. Biotech., 2015, 3(2), 018-021.
[27]
Kapoor, L.D. Handbook of Ayurvedic Medicinal Plants; CRC press: New Delhi, 2001, pp. 124-125.
[28]
Gogaṭe, V.M. Ayurvedic pharmacology and therapeutic uses of medicinal plants (Dravyagunavignyan);
[29]
Rajakumar, N.; Shivanna, M.B. Ethno-medicinal application of plants in the eastern region of Shimoga district, Karnataka, India. J. Ethnopharmacol., 2009, 126(1), 64-73.
[http://dx.doi.org/10.1016/j.jep.2009.08.010] [PMID: 19686831]
[30]
Mahendra, P.; Bisht, S. Ferula asafoetida: Traditional uses and pharmacological activity. Pharmacogn. Rev., 2012, 6(12), 141-146.
[http://dx.doi.org/10.4103/0973-7847.99948] [PMID: 23055640]
[31]
Iranshahy, M; Iranshahi, M Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gumresin)-A review. J. ethnopharmacol., 2011, 4(1), 1.
[32]
Iranshahi, M.; Kalategi, F.; Rezaee, R.; Shahverdi, A.; Ito, C.; Furukawa, H.; Tokuda, H.; Itoigawa, M. Cancer chemopreventive activity of terpenoid coumarins from Ferula species. Planta Med., 2008, 74(2), 147-150.
[http://dx.doi.org/10.1055/s-2008-1034293] [PMID: 18240102]
[33]
Abd El-Razek, M.H.; Ohta, S.; Ahmed, A.A.; Hirata, T. Sesquiterpene coumarins from the roots of Ferula assa-foetida. Phytochemistry, 2001, 58(8), 1289-1295.
[http://dx.doi.org/10.1016/S0031-9422(01)00324-7] [PMID: 11738424]
[34]
Appendino, G.; Maxia, L.; Bascope, M.; Houghton, P.J.; Sanchez-Duffhues, G.; Muñoz, E.; Sterner, O. A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida. J. Nat. Prod., 2006, 69(7), 1101-1104.
[http://dx.doi.org/10.1021/np0600954] [PMID: 16872156]
[35]
Bandyopadhyay, D.; Basak, B.; Chatterjee, A.; Lai, T.K.; Banerji, A.; Banerji, J.; Neuman, A.; Prangé, T. Saradaferin, a new sesquiterpenoid coumarin from Ferula assafoetida. Nat. Prod. Res., 2006, 20(10), 961-965.
[http://dx.doi.org/10.1080/14786410600823431] [PMID: 16854726]
[36]
Kajimoto, T.; Yahiro, K.; Nohara, T. Sesquiterpenoid and disulphide derivatives from ferula assa-foetida. Phytochemistry, 1989, 28(6), 1761-1763.
[http://dx.doi.org/10.1016/S0031-9422(00)97841-5]
[37]
Abd El-Razek, M.H. A new ester isolated from Ferula assafoetida L. Biosci. Biotechnol. Biochem., 2007, 71(9), 2300-2303.
[http://dx.doi.org/10.1271/bbb.70065] [PMID: 17690448]
[38]
Christensen, L.P.; Brandt, K. Bioactive polyacetylenes in food plants of the Apiaceae family: Occurrence, bioactivity and analysis. J. Pharm. Biomed. Anal., 2006, 41(3), 683-693.
[http://dx.doi.org/10.1016/j.jpba.2006.01.057] [PMID: 16520011]
[39]
Amalraj, A.; Gopi, S. Biological activities and medicinal properties of Asafoetida: A review. J. Tradit. Complement. Med., 2017, 7(3), 347-359.
[http://dx.doi.org/10.1016/j.jtcme.2016.11.004] [PMID: 28725631]
[40]
Appendino, G.; Tagliapietra, S.; Mario Nano, G.; Jakupovic, J. Sesquiterpene coumarin ethers from asafetida. Phytochemistry, 1993, 35(1), 183-186.
[http://dx.doi.org/10.1016/S0031-9422(00)90530-2]
[41]
Mohammadhosseini, M.; Venditti, A.; Sarker, S.D.; Nahar, L.; Akbarzadeh, A. The genus Ferula: Ethnobotany, phytochemistry and bioactivities - A review. Ind. Crops Prod., 2019, 129, 350-394.
[http://dx.doi.org/10.1016/j.indcrop.2018.12.012]
[42]
Caglioti, L.; Naef, H.; Arigoni, D.; Jeger, O. Zur Kenntnis der Sesquiterpene und Azulene. 126. Mitteilung. Über die Inhaltsstoffe der Asa foetida I. Farnesiferol A. Helv. Chim. Acta, 1958, 41(7), 2278-2292.
[http://dx.doi.org/10.1002/hlca.19580410740]
[43]
Caglioti, L.; Naef, H.; Arigoni, D.; Jeger, O. Zur Kenntnis der Sesquiterpene und Azulene. 127. Mitteilung. Über die Inhaltsstoffe der Asa foetida II. Farnesiferol B und C. Helv. Chim. Acta, 1959, 42(7), 2557-2570.
[http://dx.doi.org/10.1002/hlca.19590420727]
[44]
Banerji, A.; Mallick, B.; Chatterjee, A.; Budzikiewics, H.; Breuer, M. Assafoetidin and ferocolicin, two sesquiterpenoid coumarins from ferula assafoetida regel. Tetrahedron Lett., 1988, 29(13), 1557-1560.
[http://dx.doi.org/10.1016/S0040-4039(00)80351-2]
[45]
Hofer, O.; Widhalm, M.; Greger, H. Circular dichroism of sesquiterpene-umbelliferone ethers and structure elucidation of a new derivative isolated from the gum resin “Asa Foetida”. Monatsh. Chem., 1984, 115(10), 1207-1218.
[http://dx.doi.org/10.1007/BF00809352]
[46]
Mallikarjuna, G.U.; Dhanalakshmi, S.; Raisuddin, S.; Ramesha Rao, A. Chemomodulatory influence of Ferula asafoetida on mammary epithelial differentiation, hepatic drug metabolizing enzymes, antioxidant profiles and N-methyl-N-nitrosourea-induced mammary carcino-genesis in rats. Breast Cancer Res. Treat., 2003, 81(1), 1-10.
[http://dx.doi.org/10.1023/A:1025448620558] [PMID: 14531492]
[47]
Fatehi, M.; Farifteh, F.; Fatehi-Hassanabad, Z. Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. J. Ethnopharmacol., 2004, 91(2-3), 321-324.
[http://dx.doi.org/10.1016/j.jep.2004.01.002] [PMID: 15120456]
[48]
al-Awadi, F.; Fatania, H.; Shamte, U. The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats. Diabetes Res., 1991, 18(4), 163-168.
[PMID: 1842751]
[49]
Al-Awadi, F.M.; Khattar, M.A.; Gumaa, K.A. On the mechanism of the hypoglycaemic effect of a plant extract. Diabetologia, 1985, 28(7), 432-434.
[http://dx.doi.org/10.1007/BF00280886] [PMID: 3899826]
[50]
Gholamnejad, Z.; Byrami, G.; Boskabady, M.H.; Iranshahi, M. Possible mechanism (s) of the relaxant effect of asafoetida (Ferula assa-foetida) oleo-gum-resin extract on guinea-pig tracheal smooth muscle. Avicenna J. Phytomed., 2011, 2(1), 10-16.
[51]
Bayrami, G.; Boskabady, M.H.; Iranshahi, M.; Gholamnezhad, Z. Relaxant effects of asafoetida extract and its constituent umbelliprenin on guinea-pig tracheal smooth muscle. Chin. J. Integr. Med; , 2013, pp. 1-6.
[http://dx.doi.org/10.1007/s11655-013-1550-3] [PMID: 24338082]
[52]
Kamanna, V.S.; Chandrasekhara, N. Effect of garlic (Allium sativum linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol. Lipids, 1982, 17(7), 483-488.
[http://dx.doi.org/10.1007/BF02535329] [PMID: 7121209]
[53]
Bagheri, S.M.; Sahebkar, A.; Gohari, A.R.; Saeidnia, S.; Malmir, M.; Iranshahi, M. Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species. Pharm. Biol., 2010, 48(3), 242-246.
[http://dx.doi.org/10.3109/13880200903081796] [PMID: 20645807]
[54]
Azizian, H; Rezvani, M.E. Anti-Obesity, Fat Lowering and Liver Steatosis Protective Effects of Ferula asafoetida Gum in Type 2 Diabetic Rats: Possible Involvement of Leptin Iranian J. Diabet. Obes., 2012, 4(3), 1-7.
[55]
Soni, K.B.; Rajan, A.; Kuttan, R. Inhibition of aflatoxin-induced liver damage in ducklings by food additives. Mycotoxin Res., 1993, 9(1), 22-26.
[http://dx.doi.org/10.1007/BF03192228] [PMID: 23606063]
[56]
Sambaiah, K.; Srinivasan, K. Influence of spices and spice principles on hepatic mixed function oxygenase system in rats. Indian J. Biochem. Biophys., 1989, 26(4), 254-258.
[PMID: 2628260]
[57]
Rahlfs, V.W.; Mössinger, P. [Asa foetida in the treatment of the irritable colon: A double-blind trial (author's transl)]. Dtsch. Med. Wochenschr., 1979, 104(4), 140-143.
[58]
Alqasoumi, S. Anxiolytic effect of Ferula assafoetida L. in rodents. J. Pharmacogn. Phytother., 2012, 4(6), 86-90.
[http://dx.doi.org/10.5897/JPP12.027]
[59]
Gundamaraju, R. Evaluation of anti-helmintic activity of Ferula foetida “Hing- A natural Indian spice” aqueous extract. Asian Pac. J. Trop. Dis., 2013, 3(3), 189-191.
[http://dx.doi.org/10.1016/S2222-1808(13)60038-9]
[60]
Tayeboon, G.S.; Tavakoli, F.; Hassani, S.; Khanavi, M.; Sabzevari, O.; Ostad, S.N. Effects of Cymbopogon citratus and Ferula assa-foetida extracts on glutamate-induced neurotoxicity. In Vitro Cell. Dev. Biol. Anim., 2013, 49(9), 706-715.
[http://dx.doi.org/10.1007/s11626-013-9656-7] [PMID: 23949776]
[61]
Homayouni Moghadam, F.; Dehghan, M.; Zarepur, E.; Dehlavi, R.; Ghaseminia, F.; Ehsani, S.; Mohammadzadeh, G.; Barzegar, K. Oleo gum resin of Ferula assa-foetida L. ameliorates peripheral neuropathy in mice. J. Ethnopharmacol., 2014, 154(1), 183-189.
[http://dx.doi.org/10.1016/j.jep.2014.03.069] [PMID: 24709312]
[62]
Soudamini, K.K.; Unnikrishnan, M.C.; Sukumaran, K.; Kuttan, R. Mutagenicity and anti-mutagenicity of selected spices. Indian J. Physiol. Pharmacol., 1995, 39(4), 347-353.
[PMID: 8582746]
[63]
Muturi, E.J.; Ramirez, J.L.; Zilkowski, B.; Flor-Weiler, L.B.; Rooney, A.P. Ovicidal and larvicidal effects of garlic and asafoetida essential oils against West Nile virus vectors. J. Insect Sci., 2018, 18(2), 43.
[http://dx.doi.org/10.1093/jisesa/iey036] [PMID: 29718505]
[64]
Gopi, S.; Amalraj, A.; Jude, S.; Varma, K.; Sreeraj, T.R.; Haponiuk, J.T.; Thomas, S. Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber. Mater. Sci. Eng. C, 2017, 81, 20-31.
[http://dx.doi.org/10.1016/j.msec.2017.07.037] [PMID: 28887965]
[65]
Devanesan, S.; Ponmurugan, K.; AlSalhi, M.S.; Al-Dhabi, N.A. Cytotoxic and antimicrobial efficacy of silver nanoparticles synthesized using a traditional phytoproduct, asafoetida gum. Int. J. Nanomedicine, 2020, 15, 4351-4362.
[http://dx.doi.org/10.2147/IJN.S258319] [PMID: 32606682]
[66]
Niazmand, R.; Razavizadeh, B.M. Ferula asafoetida: Chemical composition, thermal behavior, antioxidant and antimicrobial activities of leaf and gum hydroalcoholic extracts. J. Food Sci. Technol., 2021, 58(6), 2148-2159.
[http://dx.doi.org/10.1007/s13197-020-04724-8] [PMID: 33967312]
[67]
Cha, M.R.; Choi, Y.; Choi, C.; Kim, Y.; Kim, Y.K.; Ryu, S.; Kim, Y.; Choi, S. Galbanic acid, a cytotoxic sesquiterpene from the gum resin of Ferula asafoetida, blocks protein farnesyltransferase. Planta Med., 2011, 77(1), 52-54.
[http://dx.doi.org/10.1055/s-0030-1250049] [PMID: 20560115]
[68]
Iranshahi, M.; Alizadeh, M. Antihyperglycemic effect of Asafoetida (Ferula assafoetida Oleo-Gum-Resin) in streptozotocin-induced dia-betic rats. World Appl. Sci. J., 2012, 17(2), 157-162.
[69]
Bagheri, S.M.; Dashti-R, M.H.; Morshedi, A. Antinociceptive effect of Ferula assa-foetida oleo-gum-resin in mice. Res. Pharm. Sci., 2014, 9(3), 207-212.
[PMID: 25657791]
[70]
Bagheri, S.M.; Dashti-R, M.H. Influence of asafoetida on prevention and treatment of memory impairment induced by d-galactose and NaNO2 in mice. Am. J. Alzheimers Dis. Other Demen., 2015, 30(6), 607-612.
[http://dx.doi.org/10.1177/1533317515576388] [PMID: 25788433]
[71]
Esmaeili, H.; Esmailidehaj, M.; Entezari Zarch, S.; Azizian, H. Role of the potassium channels in vasorelaxant effect of asafoetida essential oil. Avicenna J. Phytomed., 2020, 10(4), 407-416.
[PMID: 32850297]
[72]
Esmaeili, H.; Hafezimoghadam, Z.; Esmailidehaj, M.; Rezvani, M.E.; Hafizibarjin, Z. The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts. Avicenna J. Phytomed., 2018, 8(4), 338-349.
[PMID: 30377592]
[73]
Hejazian, S.H.; Dashti-R, M.H.; Bagheri, S.M. The relaxant effect of seed fs essential oil and oleo-gum-resin of Ferula assa-foetida on isolated rat’s ileum. Ann. Med. Health Sci. Res., 2014, 4(2), 238-241.
[http://dx.doi.org/10.4103/2141-9248.129050] [PMID: 24761245]
[74]
Adiga, S.; Bhat, P.; Chaturvedi, A.; Bairy, K.L.; Kamath, S.; Vijayalakshmi, Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats. Indian J. Pharmacol., 2012, 44(1), 82-87.
[http://dx.doi.org/10.4103/0253-7613.91873] [PMID: 22345876]
[75]
Verma, S.; Khambhala, P.; Joshi, S.; Kothari, V.; Patel, T.; Seshadri, S. Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: In vitro studies. Exp. Oncol., 2019, 41(2), 90-94.
[http://dx.doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-2.12989] [PMID: 31262162]
[76]
Bagheri, S.M.; Abdian-Asl, A.; Moghadam, M.T.; Yadegari, M.; Mirjalili, A.; Zare-Mohazabieh, F.; Momeni, H. Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice. J. Ayurveda Integr. Med., 2017, 8(3), 152-158.
[http://dx.doi.org/10.1016/j.jaim.2017.02.013] [PMID: 28690055]
[77]
Panwar, R.; Rana, S.; Dhawan, D.K.; Prasad, K.K. Chemopreventive efficacy of different doses of Ferula asafoetida oleo-gum-resin against 1,2-dimethylhydrazine (DMH) induced rat colon carcinogenesis. J. Phytopharmacology, 2016, 4(6), 282-286.
[http://dx.doi.org/10.31254/phyto.2015.4602]
[78]
Illuri, R.; Venkataramana, S.H.; Daguet, D.; Kodimule, S. Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying. BMC Complement. Altern. Med., 2019, 19(1), 159.
[http://dx.doi.org/10.1186/s12906-019-2576-7] [PMID: 31277639]
[79]
Bagheri, S.M.; Maghsoudi, M.J.; Yadegari, M. Preventive effect of Ferula asafoetida oleo gum resin on histopathology in cuprizone-induced demyelination mice. Int. J. Prev. Med., 2020, 11, 179.
[PMID: 33456735]
[80]
Bagheri, S.M.; Asl, A.A.; Shams, A.; Mirghanizadeh-Bafghi, S.A.; Hafizibarjin, Z. Evaluation of Cytotoxicity Effects of Oleo-Gum-Resin and Its Essential Oil of Ferula assa-foetida and Ferulic Acid on 4T1 Breast Cancer Cells. Indian J. Med. Paediatr. Oncol., 2017, 38(2), 116-120.
[PMID: 28900317]
[81]
Mallahi, T.; Ramezanian, A.; Saharkhiz, M.J.; Javanmardi, J.; Iraji, A. Antimicrobial activities of Asafoetida and Shirazi thyme essential oils improve the vase life of gerbera cut flowers. Acta Ecol. Sin., 2018, 38(3), 228-233.
[http://dx.doi.org/10.1016/j.chnaes.2017.08.009]
[82]
Bagheri, S.; Javidmehr, D.; Ghaffari, M.; Ghoderti-Shatori, E. Chemical compositions and antiproliferative effect of essential oil of asafoetida on MCF7 human breast cancer cell line and female wistar rats. Cancer Transl. Med., 2020, 6(2), 34.
[http://dx.doi.org/10.4103/ctm.ctm_36_19]
[83]
Narayanan, R.; Gilbert, B.; Ravichandran, S.; Bhuvaneswari, K. Psychopharmacological characterization of effects of Ferula asafoetida linn. formulation in mouse on a Y-maze, EPM, and open field apparatus. Int. J. Basic Clin. Pharmacol., 2017, 6(9), 2254-2258.
[http://dx.doi.org/10.18203/2319-2003.ijbcp20173755]
[84]
Patil, S; Gaikwad, S; Deshmukh, N. Phytochemical investigation and in vitro thrombolytic activity of methanolic extract of Ferula foetida l. exudates. Pharmanest, 2015, 6(2), 2828-2830.
[85]
Iranshahy, M.; Farhadi, F.; Paknejad, B.; Zareian, P.; Iranshahi, M.; Karami, M.; Abtahi, S.R. Gummosin, a sesquiterpene coumarin from Ferula assa-foetida is preferentially cytotoxic to human breast and prostate cancer cell lines. Avicenna J. Phytomed., 2019, 9(5), 446-453.
[PMID: 31516858]
[86]
Harve, G; Kamath, V. Larvicidal activity of plant extracts used alone and in combination with known synthetic larvicidal agents against Aedes aegypti. Indian J. Exp. Biol., 2004, 42(12), 1216-1219.
[87]
Rezvani, M.E.; Vahidi, A.R.; Esmaili, M.; Bagheri, S.M. Anticonvulsant effect of ferula assa-foetida oleo gum resin on chemical and amygdala-kindled rats. N. Am. J. Med. Sci., 2014, 6(8), 408-412.
[http://dx.doi.org/10.4103/1947-2714.139296] [PMID: 25210675]
[88]
Bagheri, S.M.; Mohammadsadeghi, H.; Dashti-R, M.H.; Mousavian, S.M.M.; Aghaei, Z.A. Effect of Ferula assa-foetida oleo-gum-resin on renal function in normal Wistar rats. Indian J. Nephrol., 2016, 26(6), 419-422.
[http://dx.doi.org/10.4103/0971-4065.171245] [PMID: 27942173]
[89]
Esmaeili, H.; Sharifi, M.; Esmailidehaj, M.; Rezvani, M.E.; Hafizibarjin, Z. Vasodilatory effect of asafoetida essential oil on rat aorta rings: The role of nitric oxide, prostacyclin, and calcium channels. Phytomedicine, 2017, 36, 88-94.
[http://dx.doi.org/10.1016/j.phymed.2017.10.002] [PMID: 29157833]
[90]
Sharma, V.; Bisht, S.; Singh, M. Hepatoprotective and antidyslipidemic effect of in CCl induced Ferula asafoetida. Asian J. Pharm. Pharmacol., 2018, 4(1), 61-65.
[http://dx.doi.org/10.31024/ajpp.2018.4.1.10]
[91]
Bagheri, S.; Yadegari, M.; Behpur, M.; Javidmehr, D. Antilithiatic and hepatoprotective effects of Ferula assa-foetida oleo-gumresin on ethylene glycol-induced lithiasis in rats. Urol. Sci., 2018, 20(40), 180-185.
[http://dx.doi.org/10.4103/UROS.UROS_10_18]
[92]
Ramadan, N.I.; Al Khadrawy, F.M. The in vitro effect of Assafoetida on Trichomonas vaginalis. J. Egypt. Soc. Parasitol., 2003, 33(2), 615-630.
[PMID: 14964671]
[93]
Tavassoli, M.; Jalilzadeh-Amin, G.; Fard, V.R.B.; Esfandiarpour, R. The in vitro effect of Ferula asafoetida and Allium sativum extracts on Strongylus spp. Ann. Parasitol., 2018, 64(1), 59-63.
[PMID: 29717575]
[94]
Khazdair, M.R.; Boskabady, M.H. The relaxant effect of Ferula assafoetida on smooth muscles and the possible mechanisms. J. HerbMed Pharmacol., 2015, 4(2), 40-44.
[95]
Platel, K; Srinivasan, K. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung, 2000, 44(1), 42-46.
[http://dx.doi.org/10.1002/(SICI)1521-3803(20000101)44:1<42::AID-FOOD42>3.0.CO;2-D]
[96]
Ramakrishna Rao, R; Platel, K; Srinivasan, K. In vitro influence of spices and spice‐active principles on digestive enzymes of rat pancreas and small intestine. Nahrung, 2003, 47(6), 408-412.
[http://dx.doi.org/10.1002/food.200390091]
[97]
Dandagi, P.M.; Patil, M.B.; Mastiholimath, V.S.; Gadad, A.P.; Dhumansure, R.H. Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants. Indian J. Pharm. Sci., 2008, 70(2), 265-268.
[http://dx.doi.org/10.4103/0250-474X.41474] [PMID: 20046731]
[98]
Kamble, V.A.; Patil, S.D. Spice-derived essential oils: Effective antifungal and possible therapeutic agents. J. Herbs Spices Med. Plants, 2008, 14(3-4), 129-143.
[http://dx.doi.org/10.1080/10496470802598677]
[99]
Sitara, U.; Niaz, I.; Naseem, J.; Sultana, N. Antifungal effect of essential oils on in vitro growth of pathogenic fungi. Pak. J. Bot., 2008, 40(1), 409.
[100]
Rani, A.; Jain, S.; Dureja, P. Synergistic fungicidal efficacy of formulations of neem oil, nicotinic acid and Ferula asafoetida with. ALPHA. BETA.-unsaturated carbonyl compounds against Sclerotium rolfsii ITCC 5226 & Macrophomina phaseolina ITCC 0482. J. Pestic. Sci., 2009, 34(4), 253-258.
[http://dx.doi.org/10.1584/jpestics.G09-19]
[101]
Mostafa, Z.; Soheil, P.; Mahdi, J.; Mahmoodi, S. Antifangal effects of asafoetida seed essential oil on in vitro growth of five species of plant pathogenic fungi. Int. Res. J. Appl. Basic Sci., 2013, 4(5), 1159-1162.
[102]
Unnikrishnan, M.C.; Kuttan, R. Tumour reducing and anticarcinogenic activity of selected spices. Cancer Lett., 1990, 51(1), 85-89.
[http://dx.doi.org/10.1016/0304-3835(90)90235-P] [PMID: 2110862]
[103]
Sepahi, E.; Tarighi, S.; Ahmadi, F.S.; Bagheri, A. Inhibition of quorum sensing in Pseudomonas aeruginosa by two herbal essential oils from Apiaceae family. J. Microbiol., 2015, 53(2), 176-180.
[http://dx.doi.org/10.1007/s12275-015-4203-8] [PMID: 25564444]
[104]
Kiyanmehr, M.; Boskabady, M.H.; Khazdair, M.R.; Hashemzehi, M. Possible mechanisms for functional antagonistic effect of Ferula assafoetida on muscarinic receptors in tracheal smooth muscle. Malays. J. Med. Sci., 2016, 23(1), 35-43.
[PMID: 27540324]
[105]
Asafoetida. Global Asafoetida Market 2021. Available From: https://asafoetida.in/sticky-post/
[106]
Trade Promotion Council Of India. Asafoetida finally acquires Indian roots. 2020. Available From: https://www.tpci.in/indiabusinesstrade/blogs/asafoetida-finally-acqui res-indian-roots/
[107]
Murti, Y.; Semwal, B.C.; Goyal, A.; Mishra, P. Naringenin scaffold as a template for drug designing. Curr. Tradit. Med., 2021, 7(1), 28-44.
[http://dx.doi.org/10.2174/2215083805666190617144652]
[108]
Singh, S.; Kumar, A.; Semwal, B.C. PRISMA Based Systematic Review: Pharmacognostic Study of Zanthoxylum armatum DC. Mini Rev. Med. Chem., 2021, 21(14), 1965-1997.
[http://dx.doi.org/10.2174/1389557521999201230200503] [PMID: 33390134]
[109]
Verma, T.; Sinha, M.; Bansal, N.; Yadav, S.R.; Shah, K.; Chauhan, N.S. Plants used as antihypertensive. Nat. Prod. Bioprospect., 2021, 11(2), 155-184.
[http://dx.doi.org/10.1007/s13659-020-00281-x] [PMID: 33174095]
[110]
Garabadu, D.; Srivastava, N.; Murti, Y. Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experi-mental animals. Metab. Brain Dis., 2019, 34(6), 1635-1647.
[http://dx.doi.org/10.1007/s11011-019-00471-8] [PMID: 31346860]
[111]
Murti, Y.; Mishra, P. Synthesis, characterization, and biological evaluation of novel naringenin derivatives as anticancer agents. Curr. Bioact. Compd., 2020, 16(4), 442-448.
[http://dx.doi.org/10.2174/1573407215666181214114927]
[112]
Tan, C.X. Virgin avocado oil: An emerging source of functional fruit oil. J. Funct. Foods, 2019, 54, 381-392.
[http://dx.doi.org/10.1016/j.jff.2018.12.031]
[113]
Tan, C.X.; Chong, G.H.; Hamzah, H.; Ghazali, H.M. Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet-induced hypercholesterolaemia rats. Int. J. Food Sci. Technol., 2018, 53(12), 2706-2713.
[http://dx.doi.org/10.1111/ijfs.13880]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy