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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Natural and Synthetic Peptides to Control Drug-resistant Pathogens

Author(s): Francisca J.F. de Sousa, Igor R.S. Costa, Francisco L.P. Cavalcante, Ana J.O. Silva, Daiane M.S. Brito, José Y.G. da Silva, José J.L. Silva, Camila G.L. Almeida, Felipe P. Mesquita and Pedro F.N. Souza*

Volume 24, Issue 7, 2023

Published on: 10 July, 2023

Page: [567 - 578] Pages: 12

DOI: 10.2174/1389203724666230621121330

Price: $65

Abstract

Due to the excessive and inappropriate use of antibiotics in farming and clinic, pathogens developed resistance mechanisms to currently used drugs. Thus, because of this resistance, drugs become ineffective, leading to public health problems worldwide. According to the World Health Organization (WHO), microbial resistance to drugs is one of the most threats that humanity must face. Therefore, it is imperative to seek alternative methods to overcome microbial resistance. Here, the potential of natural or synthetic antimicrobial peptides to overcome microbial resistance will be discussed, and how peptides could be a source for new therapeutics molecules. In this context, antimicrobial peptides (natural or synthetic) are considered promising molecules based on their antifungal, antiviral, and antibacterial properties, making them eligible for developing new drugs. In addition, they can act synergistically with existing drugs on the market, revealing a broad spectrum of applications.

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