Abstract
Background: One of the most challenging effects of diabetes is diabetic foot ulceration (DFU). DFU may occur in up to one-third of individuals with diabetes mellitus (D.M.) at some point in their lives. The major cause of morbidity in D.M. patients is DFU. The length of treatment is difficult, and DFU recurrence is common.
Objective: The most crucial element for the treatment and prevention of DFUs require a multidisciplinary approach. Patients who are at risk should be identified, depending on the type of risk, prophylactic actions etc. It is imperative to identify at-risk patients and take preventative measures accordingly.
Method: The at-risk diabetes-related foot ulcer was identified based on the risk category classification, while the foot ulcers were evaluated using Wagner's classification system.
Results: Literature reported that patients with lower limb vascular insufficiency, loss of vibratory sensation, or protective sensation loss have an increased risk of developing foot ulcers. Proper categorization and therapeutic measures will be implemented after the DFU has been formed. The appropriate assessment and management of general health status should include glycemic control, the diagnosis and treatment of vascular disease, standard care for wounds, diagnosis, and infection treatments.
Conclusion: The review reflects the updated awareness of the treatment and management of DFU based on the current and past literature and patent analysis.
[http://dx.doi.org/10.12669/pjms.293.3473] [PMID: 24353617]
[http://dx.doi.org/10.4239/wjd.v3.i6.110]
[http://dx.doi.org/10.1016/j.diabres.2009.10.007] [PMID: 19896746]
[http://dx.doi.org/10.1016/j.diabres.2011.10.029] [PMID: 22079683]
[http://dx.doi.org/10.1186/2251-6581-11-24] [PMID: 23497582]
[http://dx.doi.org/10.1016/j.jaad.2013.07.048] [PMID: 24355276]
[http://dx.doi.org/10.3390/futurepharmacol2040032]
[http://dx.doi.org/10.1111/iwj.13010] [PMID: 30393976]
[http://dx.doi.org/10.1016/S0002-9610(03)00299-X] [PMID: 15147985]
[http://dx.doi.org/10.1155/2017/2923759]
[http://dx.doi.org/10.4239/wjd.v7.i7.153] [PMID: 27076876]
[http://dx.doi.org/10.1016/j.dsx.2015.04.002] [PMID: 26072202]
[http://dx.doi.org/10.1080/07853890.2016.1231932] [PMID: 27585063]
[http://dx.doi.org/10.2174/1573399816666200109094329] [PMID: 31916518]
[http://dx.doi.org/10.1186/s13098-022-00901-1]
[http://dx.doi.org/10.2337/dc21-S011] [PMID: 33298422]
[http://dx.doi.org/10.1097/01.JAA.0000464276.44117.b1] [PMID: 25853673]
[http://dx.doi.org/10.31128/AJGP-05-20-1234e] [PMID: 32416648]
[http://dx.doi.org/10.1001/jama.293.2.217] [PMID: 15644549]
[http://dx.doi.org/10.1007/s40257-019-00495-x] [PMID: 31848923]
[http://dx.doi.org/10.2174/1573399812666151210143140] [PMID: 26652612]
[http://dx.doi.org/10.1002/dmrr.3276] [PMID: 31958217]
[http://dx.doi.org/10.1016/j.ejvs.2010.09.020] [PMID: 21095144]
[http://dx.doi.org/10.1177/1071100715611951] [PMID: 26475457]
[http://dx.doi.org/10.1016/j.mvr.2013.05.004] [PMID: 23727385]
[http://dx.doi.org/10.31128/AJGP-11-19-5161] [PMID: 32416652]
[http://dx.doi.org/10.1016/j.yexcr.2004.10.033] [PMID: 15707592]
[http://dx.doi.org/10.1159/000081919] [PMID: 15608477]
[http://dx.doi.org/10.1007/s12663-016-0880-z] [PMID: 29038623]
[http://dx.doi.org/10.1152/physrev.2003.83.3.835] [PMID: 12843410]
[http://dx.doi.org/10.1155/2014/920613] [PMID: 24551859]
[http://dx.doi.org/10.1017/S1462399409000945] [PMID: 19138453]
[http://dx.doi.org/10.1016/S0140-6736(05)67700-8] [PMID: 16291068]
[http://dx.doi.org/10.1111/j.1365-2133.2008.08789.x] [PMID: 18717678]
[http://dx.doi.org/10.1016/S0002-9440(10)63754-6] [PMID: 15161630]
[http://dx.doi.org/10.2337/diacare.28.2.461] [PMID: 15677818]
[http://dx.doi.org/10.1111/wrr.12437] [PMID: 27102877]
[http://dx.doi.org/10.1002/14651858.CD007610.pub3] [PMID: 26299991]
[http://dx.doi.org/10.2337/dc17-1836] [PMID: 29559450]
[http://dx.doi.org/10.1002/dmrr.2707] [PMID: 26344936]
[http://dx.doi.org/10.1016/j.jtv.2020.03.003] [PMID: 32197948]
[http://dx.doi.org/10.1002/dmrr.2697] [PMID: 26813614]
[http://dx.doi.org/10.1016/j.ecl.2021.05.005] [PMID: 34399955]
[http://dx.doi.org/10.1002/14651858.CD008143.pub3] [PMID: 24214280]
[http://dx.doi.org/10.12968/jowc.2017.26.6.324] [PMID: 28598756]
[http://dx.doi.org/10.1007/s00125-008-0940-0] [PMID: 18297261]
[http://dx.doi.org/10.1186/s12902-016-0111-0] [PMID: 27388440]
[http://dx.doi.org/10.3390/healthcare4010018] [PMID: 27417606]
[http://dx.doi.org/10.1002/14651858.CD005083.pub4] [PMID: 25742878]
[http://dx.doi.org/10.1016/j.ctcp.2016.06.003] [PMID: 27502813]
[http://dx.doi.org/10.1093/cid/cis346] [PMID: 22619242]
[http://dx.doi.org/10.1517/14656566.2015.1021780] [PMID: 25736920]
[http://dx.doi.org/10.1111/ijcp.13006] [PMID: 28892282]
[http://dx.doi.org/10.1177/1534734614521234] [PMID: 24659624]
[http://dx.doi.org/10.2337/dc07-1178] [PMID: 17934144]
[http://dx.doi.org/10.1002/14651858.CD009101.pub3] [PMID: 23846869]
[http://dx.doi.org/10.1186/s13047-015-0065-x]
[http://dx.doi.org/10.1016/j.clinthera.2013.09.013] [PMID: 24145042]
[http://dx.doi.org/10.12968/bjcn.2017.22.Sup6.S14]
[http://dx.doi.org/10.7547/0950254] [PMID: 15901812]
[http://dx.doi.org/10.5070/D3228032089]
[http://dx.doi.org/10.1111/wrr.12561] [PMID: 28783878]
[http://dx.doi.org/10.1002/14651858.CD010318] [PMID: 24132761]
[http://dx.doi.org/10.2147/TCRM.S131193] [PMID: 28458556]
[http://dx.doi.org/10.1016/j.ijsu.2017.02.008] [PMID: 28232031]
[http://dx.doi.org/10.1684/ejd.2009.0750] [PMID: 19638336]
[http://dx.doi.org/10.4103/0976-9668.136160] [PMID: 25097397]
[http://dx.doi.org/10.1111/wrr.12187] [PMID: 25041620]
[http://dx.doi.org/10.3944/AOTT.2015.14.0434] [PMID: 27130382]
[http://dx.doi.org/10.1002/14651858.CD008548.pub2] [PMID: 26509249]
[http://dx.doi.org/10.1016/j.avsg.2016.04.023] [PMID: 27522981]
[http://dx.doi.org/10.1111/wrr.12294] [PMID: 25847503]
[http://dx.doi.org/10.1002/14651858.CD011255.pub2] [PMID: 26866804]
[http://dx.doi.org/10.1111/iwj.12204] [PMID: 24373098]
[http://dx.doi.org/10.1016/j.diabres.2017.03.012] [PMID: 28371685]
[http://dx.doi.org/10.12968/jowc.2016.25.11.641]
[http://dx.doi.org/10.12968/jowc.2016.25.12.704] [PMID: 27974006]
[http://dx.doi.org/10.1007/s40618-017-0666-2] [PMID: 28378156]
[http://dx.doi.org/10.1002/14651858.CD011979.pub2] [PMID: 28657134]