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Current Hypertension Reviews

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ISSN (Print): 1573-4021
ISSN (Online): 1875-6506

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Mini-Review Article

Role of Plant Bioactive as Diuretics: General Considerations and Mechanism of Diuresis

Author(s): Manvi, Mohammad Irfan Khan*, Badruddeen, Juber Akhtar, Mohammad Ahmad, Zeba Siddiqui and Gayyur Fatima

Volume 19, Issue 2, 2023

Published on: 19 July, 2023

Page: [79 - 92] Pages: 14

DOI: 10.2174/1573402119666230612115220

Price: $65

Abstract

Background: Medicinal plants have been found beneficial in the control and therapy of many ailments as they contain bioactive compounds, and many of them are used as precursors in the biosynthesis of natural medicines. Diuretics are used as a primary treatment in patients with edema associated with liver cirrhosis and kidney diseases, hyperkalemia, hypertension, heart failure, or renal failure. Furthermore, they are also used to increase the excretion of sodium and reduce blood volume. Due to various adverse events associated with synthetic diuretics, there is a need to investigate alternate plant-based bioactive components that have effective diuretic activity with minimal side effects.

Objective: This review compiled the reported bioactive compounds from different plant sources along with their mechanisms of diuretic activity.

Methods: Different sources were used to collect information regarding herbal plants with therapeutic value as diuretics. These included published peer-reviewed journal articles, scholarly articles from StatPearls, and search engines like Google Scholar, PubMed, Scopus, Springer, ScienceDirect, Wiley, etc.

Results: In this review, it was found that flavonoids like rutin, acacetin, naringenin, etc. showed significant diuretic activity in experimental models by various mechanisms, but mostly by blocking the sodium-potassium-chloride co-transporter, while some bioactive compounds showed diuretic actions via other mechanisms as well.

Conclusion: Research on clinical trials of these isolated bioactive compounds needs to be further conducted. Thus, this review provides an understanding of the potential diuretic bioactive compounds of plants for further research and pharmaceutical applications.

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Graphical Abstract

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