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Review Article

COVID-19 related Complications during Pregnancy: A Systematic Review

Author(s): Basheer Abdullah Marzoog*

Volume 4, Issue 2, 2023

Published on: 18 July, 2023

Article ID: e190523217118 Pages: 12

DOI: 10.2174/0250688204666230519145707

Price: $0

Abstract

Background: The topic of COVID-19 (coronavirus disease)-associated complications during pregnancy is poorly postulated and remains an area that requires elucidation for the underlying pathophysiology mechanism in order to evaluate a new therapeutic strategy and optimize current therapies.

Aim: The study aimed to assess the proportion of associated complications with COVID-19 and the underlying pathophysiology in pregnant women.

Methods: The MedLine and Embase databases were searched for studies relevant to the study topic.

Results: Preterm delivery and C-section have been found to be the most frequently reported complications. Approximately, 28.55% of pregnant women with symptomatic COVID-19 have been reported to require a C-section and 8.8% preterm delivery. In addition, anxiety and depression have also been frequently reported in 57% and 37% of pregnant women, respectively.

Conclusion: Symptomatic pregnant women with COVID-19 have a high risk of preterm labor, mortality and morbidity rates, and C-section requirements. The underlying pathophysiology of COVID-19-associated complications during pregnancy includes homeostatic disturbances of the immune system, pulmonary system, and hemostatic system. In addition to endothelial dysfunction, excessive immune response, coagulopathy, hypoxemia, and hypotension are involved in the pathogenesis that negatively affects neonates' health outcomes.

[1]
Harel L, Eliasi E, Lifshitz S J, et al. Does the presence of symptoms affect pregnancy outcomes in third trimester in women with SARS-CoV-2. J Matern -Fetal Neonatal Med 2021; 7582-9.
[http://dx.doi.org/10.1080/14767058.2021.1956895]
[2]
Trombetta A, Comar M, Tommasini A, et al. SARS-CoV-2 infection and inflammatory response in a twin pregnancy. Int J Environ Res Public Health 2021; 18(6): 3075.
[http://dx.doi.org/10.3390/ijerph18063075] [PMID: 33802696]
[3]
Kumar V, Prasath A, Blanco C, et al. Respiratory failure in an extremely premature neonate with COVID-19. Children 2021; 8(6): 477.
[http://dx.doi.org/10.3390/children8060477] [PMID: 34200043]
[4]
Dávila-Aliaga C, Espínola-Sánchez M, Mendoza-Ibáñez E, et al. Perinatal outcomes and serological results in neonates of pregnant women seropositive to SARS-CoV-2: A cross-sectional descriptive study. Medwave 2020; 20(11): e8084-4.
[http://dx.doi.org/10.5867/medwave.2020.11.8084] [PMID: 33382393]
[5]
Mullins E, Hudak ML, Banerjee J, et al. Pregnancy and neonatal outcomes of COVID-19: Coreporting of common outcomes from PAN-COVID and AAP-SONPM registries. Ultrasound Obstet Gynecol 2021; 57(4): 573-81.
[http://dx.doi.org/10.1002/uog.23619] [PMID: 33620113]
[6]
Yang R, Mei H, Zheng T, et al. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: A population-based cohort study in Wuhan, China. BMC Med 2020; 18(1): 330.
[http://dx.doi.org/10.1186/s12916-020-01798-1] [PMID: 33070775]
[7]
Egerup P, Fich Olsen L, Christiansen AMH, et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns. Obstet Gynecol 2021; 137(1): 49-55.
[http://dx.doi.org/10.1097/AOG.0000000000004199] [PMID: 33116054]
[8]
Wei SQ, Bilodeau-Bertrand M, Liu S, Auger N. The impact of COVID-19 on pregnancy outcomes: A systematic review and meta-analysis. CMAJ 2021; 193(16): E540-8.
[http://dx.doi.org/10.1503/cmaj.202604] [PMID: 33741725]
[9]
Martinez-Perez O, Prats Rodriguez P, Muner Hernandez M, et al. The association between SARS-CoV-2 infection and preterm delivery: A prospective study with a multivariable analysis. BMC Pregnancy Childbirth 2021; 21(1): 273.
[http://dx.doi.org/10.1186/s12884-021-03742-4] [PMID: 33794829]
[10]
Papageorghiou AT, Deruelle P, Gunier RB, et al. Preeclampsia and COVID-19: Results from the INTERCOVID prospective longitudinal study. Am J Obstet Gynecol 2021; 225(3): 289.e1-289.e17.
[http://dx.doi.org/10.1016/j.ajog.2021.05.014] [PMID: 34187688]
[11]
Harahap A, Harianto A, Etika R, et al. Spontaneous Ileum Perforation in a premature twin with Coronavirus-19 positive mother. J Pediatr Surg Case Rep 2021; 67: 101807.
[http://dx.doi.org/10.1016/j.epsc.2021.101807] [PMID: 33564621]
[12]
Liu C, Andrusier M, Silver M, Applewhite L, Clare CA. Effect of SARS-CoV-2 infection on pregnancy outcomes in an inner-city black patient population. J Community Health 2021; 46(5): 1029-35.
[http://dx.doi.org/10.1007/s10900-021-00988-z] [PMID: 33855649]
[13]
de Vasconcelos Gaspar A, Santos Silva I. SARS-CoV-2 in Pregnancy—The First Wave. Medicina (Kaunas) 2021; 57(3): 241.
[http://dx.doi.org/10.3390/medicina57030241]
[14]
Ko JY, DeSisto CL, Simeone RM, et al. Adverse pregnancy outcomes, maternal complications, and severe illness among US delivery hospitalizations with and without a coronavirus disease 2019 (COVID-19) diagnosis. Clin Infect Dis 2021; 73 (Suppl. 1): S24-31.
[http://dx.doi.org/10.1093/cid/ciab344] [PMID: 33977298]
[15]
Singh V, Choudhary A, Datta MR, Ray A. Maternal and neonatal outcomes of COVID-19 in pregnancy: A single-centre observational study. Cureus 2021; 13(2): e13184.
[http://dx.doi.org/10.7759/cureus.13184] [PMID: 33717728]
[16]
Gurol-Urganci I, Jardine JE, Carroll F, et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: National cohort study. Am J Obstet Gynecol 2021; 225(5): 522.e1-522.e11.
[http://dx.doi.org/10.1016/j.ajog.2021.05.016] [PMID: 34023315]
[17]
Pirjani R, Hosseini R, Soori T, et al. Maternal and neonatal outcomes in COVID-19 infected pregnancies: A prospective cohort study. J Travel Med 2020; 27(7): taaa158.
[http://dx.doi.org/10.1093/jtm/taaa158] [PMID: 32889551]
[18]
Melo GC, Araújo KCGM. COVID-19 infection in pregnant women, preterm delivery, birth weight, and vertical transmission: A systematic review and meta-analysis. Cad Saude Publica 2020; 36(7): e00087320.
[http://dx.doi.org/10.1590/0102-311x00087320]
[19]
Trahan MJ, Malhamé I, O’Farrell P, et al. Obstetrical and Newborn Outcomes Among Patients With SARS-CoV-2 During Pregnancy. J Obstet Gynaecol Can 2021; 43(7): 888-892.e1.
[http://dx.doi.org/10.1016/j.jogc.2021.03.012] [PMID: 33785466]
[20]
Biasucci G, Cannalire G, Raymond A, et al. Safe Perinatal Management of Neonates Born to SARS-CoV-2 Positive Mothers at the Epicenter of the Italian Epidemic. Front Pediatr 2020; 8: 565522.
[http://dx.doi.org/10.3389/fped.2020.565522] [PMID: 33194893]
[21]
Steffen HA, Swartz SR, Jackson JB, et al. SARS-CoV-2 infection during pregnancy in a rural midwest all-delivery cohort and associated maternal and neonatal outcomes. Am J Perinatol 2021; 38(6): 614-21.
[http://dx.doi.org/10.1055/s-0041-1723938] [PMID: 33611783]
[22]
Villar J, Ariff S, Gunier RB, et al. Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection. JAMA Pediatr 2021; 175(8): 817-26.
[http://dx.doi.org/10.1001/jamapediatrics.2021.1050] [PMID: 33885740]
[23]
Caniglia EC, Magosi LE, Zash R, et al. Modest reduction in adverse birth outcomes following the COVID-19 lockdown. Am J Obstet Gynecol 2021; 224(6): 615.e1-615.e12.
[http://dx.doi.org/10.1016/j.ajog.2020.12.1198] [PMID: 33347842]
[24]
Higgins JPT, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 2011; 343(oct18 2): d5928.
[http://dx.doi.org/10.1136/bmj.d5928] [PMID: 22008217]
[25]
Jordan Z, Lockwood C, Munn Z, Aromataris E. The updated joanna briggs institute model of evidence-based healthcare. Int J Evid-Based Healthc 2019; 17(1): 58-71.
[http://dx.doi.org/10.1097/XEB.0000000000000155] [PMID: 30256247]
[26]
Di Mascio D, Khalil A, Saccone G, et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: A systematic review and meta-analysis. Am J Obstet Gynecol MFM 2020; 2(2): 100107.
[http://dx.doi.org/10.1016/j.ajogmf.2020.100107] [PMID: 32292902]
[27]
Lokken EM, Walker CL, Delaney S, et al. Clinical characteristics of 46 pregnant women with a severe acute respiratory syndrome coronavirus 2 infection in Washington State. Am J Obstet Gynecol 2020; 223(6): 911.e1-911.e14.
[http://dx.doi.org/10.1016/j.ajog.2020.05.031] [PMID: 32439389]
[28]
Savasi VM, Parisi F, Patanè L, et al. Clinical findings and disease severity in hospitalized pregnant women with coronavirus disease 2019 (COVID-19). Obstet Gynecol 2020; 136(2): 252-8.
[http://dx.doi.org/10.1097/AOG.0000000000003979] [PMID: 32433453]
[29]
Sentilhes L, De Marcillac F, Jouffrieau C, et al. Coronavirus disease 2019 in pregnancy was associated with maternal morbidity and preterm birth. Am J Obstet Gynecol 2020; 223(6): 914.e1-914.e15.
[http://dx.doi.org/10.1016/j.ajog.2020.06.022] [PMID: 32553908]
[30]
Lokken EM, Huebner EM, Taylor GG, et al. Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with severe acute respiratory syndrome coronavirus 2 infection in Washington State. Am J Obstet Gynecol 2021; 225(1): 77.e1-77.e14.
[http://dx.doi.org/10.1016/j.ajog.2020.12.1221] [PMID: 33515516]
[31]
Wang Y, Chen L, Wu T, et al. Impact of Covid-19 in pregnancy on mother’s psychological status and infant’s neurobehavioral development: A longitudinal cohort study in China. BMC Med 2020; 18(1): 347.
[http://dx.doi.org/10.1186/s12916-020-01825-1] [PMID: 33143711]
[32]
Antoun L, Taweel NE, Ahmed I, Patni S, Honest H. Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur J Obstet Gynecol Reprod Biol 2020; 252: 559-62.
[http://dx.doi.org/10.1016/j.ejogrb.2020.07.008] [PMID: 32732059]
[33]
Norman M, Navér L, Söderling J, et al. Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes. JAMA 2021; 325(20): 2076-86.
[http://dx.doi.org/10.1001/jama.2021.5775] [PMID: 33914014]
[34]
Harvey E M, McNeer E, McDonald M F, et al. Association of preterm birth rate with COVID-19 Statewide Stay-at-Home Orders in Tennessee. JAMA Pediatrics 2021; 635-7.
[http://dx.doi.org/10.1001/jamapediatrics.2020.6512]
[35]
Gulersen M, Blitz MJ, Rochelson B, Nimaroff M, Shan W, Bornstein E. Clinical Implications of SARS-CoV-2 Infection in the Viable Preterm Period. Am J Perinatol 2020; 37(11): 1077-83.
[http://dx.doi.org/10.1055/s-0040-1713851] [PMID: 32615621]
[36]
Ortiz Molina E, Hernandez Pailos R, Pola Guillen M, Pascual Pedreno A, Rodriguez Rodriguez E, Hernandez Martinez A. COVID-19 infection in symptomatic pregnant women at the midpoint of the pandemic in Spain: A retrospective analysis. Ginekol Pol 2020; 91(12): 755-63.
[http://dx.doi.org/10.5603/GP.a2020.0130] [PMID: 33447995]
[37]
Patel P, Kulkarni S, Guerrero M, Persaud C, Zuberi J, Rebein B. Emergency Cesarean Section at 38 Weeks of Gestation with COVID-19 Pneumonia: A Case Report. Am J Case Rep 2021; 22: e926591.
[http://dx.doi.org/10.12659/AJCR.926591] [PMID: 33339814]
[38]
Chen S, Bernstein P, Nair S, et al. A review of 92 obstetric patients with COVID-19 in the Bronx, New York and their peripartum anaesthetic management. Anaesthesiol Intensive Ther 2021; 53(2): 115-25.
[http://dx.doi.org/10.5114/ait.2021.105120] [PMID: 34006045]
[39]
Martínez-Perez O, Vouga M, Cruz Melguizo S, et al. Association between mode of delivery among pregnant women with COVID-19 and maternal and neonatal outcomes in Spain. JAMA 2020; 324(3): 296-9.
[http://dx.doi.org/10.1001/jama.2020.10125] [PMID: 32511673]
[40]
Carrasco I, Muñoz-Chapuli M, Vigil-Vázquez S, et al. SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave. BMC Pregnancy Childbirth 2021; 21(1): 326.
[http://dx.doi.org/10.1186/s12884-021-03784-8] [PMID: 33902483]
[41]
Cavalcante MB, Cavalcante CTMB, Sarno M, Barini R, Kwak-Kim J. Maternal immune responses and obstetrical outcomes of pregnant women with COVID-19 and possible health risks of offspring. J Reprod Immunol 2021; 143: 103250.
[http://dx.doi.org/10.1016/j.jri.2020.103250] [PMID: 33249335]
[42]
Mokhtari NB, Drassinower D, Orr LA, Cobb NK, Mims OL Jr, Landy HJ. Expectant management of severe COVID-19 pneumonia in late preterm pregnancy and subsequent cholecystitis: lessons learned. AJP Rep 2021; 11(1): e29-33.
[http://dx.doi.org/10.1055/s-0040-1721672] [PMID: 33598363]
[43]
Rosen H, Bart Y, Zlatkin R, et al. Fetal and perinatal outcome following first and second trimester COVID-19 infection: Evidence from a prospective cohort study. J Clin Med 2021; 10(10): 2152.
[http://dx.doi.org/10.3390/jcm10102152] [PMID: 34065646]
[44]
Rottenstreich A, Tsur A, Braverman N, et al. Vaginal delivery in SARS-CoV-2-infected pregnant women in Israel: A multicenter prospective analysis. Arch Gynecol Obstet 2021; 303(6): 1401-5.
[http://dx.doi.org/10.1007/s00404-020-05854-2] [PMID: 33123808]
[45]
Kolkova Z, Bjurström MF, Länsberg JK, et al. Obstetric and intensive-care strategies in a high-risk pregnancy with critical respiratory failure due to COVID-19: A case report. Case Rep Womens Health 2020; 27: e00240.
[http://dx.doi.org/10.1016/j.crwh.2020.e00240] [PMID: 32714844]
[46]
Bajpai D, Shah S. COVID-19 pandemic and pregnancy in kidney disease. Adv Chronic Kidney Dis 2020; 27(5): 397-403.
[http://dx.doi.org/10.1053/j.ackd.2020.08.005] [PMID: 33308505]
[47]
Metz TD, Clifton RG, Hughes BL, et al. Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol 2021; 137(4): 571-80.
[http://dx.doi.org/10.1097/AOG.0000000000004339] [PMID: 33560778]
[48]
Lebel C, MacKinnon A, Bagshawe M, Tomfohr-Madsen L, Giesbrecht G. Elevated depression and anxiety symptoms among pregnant individuals during the COVID-19 pandemic. J Affect Disord 2020; 277: 5-13.
[http://dx.doi.org/10.1016/j.jad.2020.07.126] [PMID: 32777604]
[49]
McFarland MJ, McFarland CAS, Hill TD, D’Oria R. Postpartum depressive symptoms during the beginning of the COVID-19 Pandemic: An examination of population birth data from central New Jersey. Matern Child Health J 2021; 25(3): 353-9.
[http://dx.doi.org/10.1007/s10995-020-03116-w] [PMID: 33492587]
[50]
Hiiragi K, Obata S, Misumi T, Miyagi E, Aoki S. Psychological stress associated with the COVID ‐19 pandemic in postpartum women in Yokohama, Japan. J Obstet Gynaecol Res 2021; 47(6): 2126-30.
[http://dx.doi.org/10.1111/jog.14776] [PMID: 33759283]
[51]
Preis H, Mahaffey B, Pati S, Heiselman C, Lobel M. Adverse perinatal outcomes predicted by prenatal maternal stress among U.S. women at the COVID-19 pandemic onset. Ann Behav Med 2021; 55(3): 179-91.
[http://dx.doi.org/10.1093/abm/kaab005] [PMID: 33724334]
[52]
Seyed A, Karimi A, Shobeiri P, et al. Psychological symptoms of COVID-19 epidemic: A systematic review of current evidence. Psihologija 2021; 54(2): 173-92.
[http://dx.doi.org/10.2298/PSI200703035S]
[53]
Wang MJ, Schapero M, Iverson R, Yarrington CD. Obstetric hemorrhage risk associated with novel COVID-19 diagnosis from a single-institution cohort in the United States. Am J Perinatol 2020; 37(14): 1411-6.
[http://dx.doi.org/10.1055/s-0040-1718403] [PMID: 32992351]
[54]
Cruz Melguizo S, de la Cruz Conty M, Carmona Payán P, et al. Pregnancy outcomes and SARS-CoV-2 infection: The Spanish obstetric emergency group study. Viruses 2021; 13(5): 853.
[http://dx.doi.org/10.3390/v13050853] [PMID: 34067086]
[55]
Bloise E, Zhang J, Nakpu J, et al. Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia. Am J Obstet Gynecol 2021; 224(3): 298.e1-8.
[http://dx.doi.org/10.1016/j.ajog.2020.08.055] [PMID: 32853537]
[56]
Marzoog BA, Vlasova TI. The possible puzzles of BCG vaccine in protection against COVID-19 infection. Egypt J Bronchol 2021; 15(1): 7.
[http://dx.doi.org/10.1186/s43168-021-00052-3]
[57]
Zhou C G, Packer C H, Hersh A R, Caughey A B. Antenatal corticosteroids for pregnant women with COVID-19 infection and preterm prelabor rupture of membranes: A decision analysis. J Matern Neonatal Med 2020; 35(9): 1643-51.
[http://dx.doi.org/10.1080/14767058.2020.1763951]
[58]
Abdullah Marzoog B. Adaptive and Compensatory Mechanisms of the Cardiovascular System and Disease Risk Factors in young males and females. Emir Med J 2022; 4
[http://dx.doi.org/10.2174/04666221128110145]
[59]
Marzoog BA. Tree of Life; Endothelial Cell Physiopathology, the Good Guy Is a Partner in Crime! Anat Cell Biol 2023.
[60]
Marzoog BA. Endothelial cell autophagy in the context of disease development. Anat Cell Biol 2023; 56(1): 16-24.
[http://dx.doi.org/10.5115/acb.22.098] [PMID: 36267005]
[61]
Marzoog BA. Local Lung Fibroblast Autophagy in the Context of Lung Fibrosis Pathogenesis. Curr Respir Med Rev 2023; 19(1): 6-11.
[http://dx.doi.org/10.2174/1573398X19666221130141600]
[62]
Marzoog B. Lipid behavior in metabolic syndrome pathophysiology. Curr Diabetes Rev 2022; 18(6): e150921196497.
[http://dx.doi.org/10.2174/1573399817666210915101321] [PMID: 34525924]
[63]
Marzoog BA. Pulmonary fibrosis; risk factors and molecular triggers, insight for neo therapeutic approach. Curr Respir Med Rev 2022; 18(4): 259-66.
[http://dx.doi.org/10.2174/1573398X18666220806124019]
[64]
Marzoog BA. Recent advances in molecular biology of metabolic syndrome pathophysiology: endothelial dysfunction as a potential therapeutic target. J Diabetes Metab Disord 2022; 21(2): 1903-11.
[http://dx.doi.org/10.1007/s40200-022-01088-y] [PMID: 36065330]
[65]
Marzoog BA, Vlasova TI. Membrane lipids under norm and pathology. Euro J Clini Exp Medi 2021; 19(1): 59-75.
[http://dx.doi.org/10.15584/ejcem.2021.1.9]
[66]
Marzoog BA, Vlasova TI. The metabolic syndrome puzzles; possible pathogenesis and management. Curr Diabetes Rev 2022; 18
[http://dx.doi.org/10.2174/1573399818666220429100411] [PMID: 35507784]
[67]
Rebutini PZ, Zanchettin AC, Stonoga ETS, et al. Association between COVID-19 Pregnant women symptoms severity and placental morphologic features. Front Immunol 2021; 12: 685919.
[http://dx.doi.org/10.3389/fimmu.2021.685919] [PMID: 34122449]
[68]
Aghaamoo S, Ghods K, Rahmanian M. Pregnant women with COVID-19: the placental involvement and consequences. J Mol Histol 2021; 52(3): 427-35.
[http://dx.doi.org/10.1007/s10735-021-09970-4] [PMID: 33871721]
[69]
Ana Orostizaga A, Francisca Apablaza R, Bárbara Garrido L, Paulina Zúñiga F, Italo Vaccarezza P, Wittkopf D. Case Report: Multidisciplinary Management in Case of 31 Weeks Pregnant Woman and COVID 19 Infection with Severe Disease Presentation | Reporte de Caso: Manejo Multidisciplinario En Gestante Con Embarazo de 31 Semanas y COVID-19 Positivo Con Evolución Grav. Rev Chil Obstet Ginecol 2020; 85: S97-S100.
[http://dx.doi.org/10.4067/S0717-75262020000700013]
[70]
Andrikopoulou M, Madden N, Wen T, et al. Symptoms and Critical Illness Among Obstetric Patients With Coronavirus Disease 2019 (COVID-19) Infection. Obstet Gynecol 2020; 136(2): 291-9.
[http://dx.doi.org/10.1097/AOG.0000000000003996] [PMID: 32459701]
[71]
Karimi-Zarchi M, Neamatzadeh H, Dastgheib SA, et al. Vertical transmission of coronavirus disease 19 (COVID-19) from infected pregnant mothers to neonates: A review. Fetal Pediatr Pathol 2020; 39(3): 246-50.
[http://dx.doi.org/10.1080/15513815.2020.1747120] [PMID: 32238084]
[72]
Liu W, Cheng H, Wang J, et al. Clinical analysis of neonates born to mothers with or without COVID-19: A retrospective analysis of 48 cases from two neonatal intensive care units in hubei province. Am J Perinatol 2020; 37(13): 1317-23.
[http://dx.doi.org/10.1055/s-0040-1716505] [PMID: 32892325]
[73]
Joma M, Fovet CM, Seddiki N, Gressens P, Laforge M. COVID-19 and pregnancy: Vertical transmission and inflammation impact on newborns. Vaccines (Basel) 2021; 9(4): 391.
[http://dx.doi.org/10.3390/vaccines9040391] [PMID: 33921113]
[74]
Vivanti AJ, Vauloup-Fellous C, Prevot S, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun 2020; 11(1): 3572.
[http://dx.doi.org/10.1038/s41467-020-17436-6] [PMID: 32665677]
[75]
Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med 2020; 144(7): 799-805.
[http://dx.doi.org/10.5858/arpa.2020-0901-SA] [PMID: 32180426]
[76]
Gulersen M, Prasannan L, Tam Tam H, et al. Histopathologic evaluation of placentas after diagnosis of maternal severe acute respiratory syndrome coronavirus 2 infection. Am J Obstet Gynecol MFM 2020; 2(4): 100211.
[http://dx.doi.org/10.1016/j.ajogmf.2020.100211] [PMID: 32838277]
[77]
Springer D, Jiskra J, Limanova Z, Zima T, Potlukova E. Thyroid in pregnancy: From physiology to screening. Crit Rev Clin Lab Sci 2017; 54(2): 102-16.
[http://dx.doi.org/10.1080/10408363.2016.1269309] [PMID: 28102101]
[78]
Ana KMS, Karina MS, Thaíla CC. Immunological aspects of pregnancy (Obzor Literature). J Clin Neonatol 2013; 4(4): 31-4.
[http://dx.doi.org/10.24966/NCP-878X/100016]
[79]
Vasilopoulou E, Loubière LS, Lash GE, et al. Triiodothyronine regulates angiogenic growth factor and cytokine secretion by isolated human decidual cells in a cell-type specific and gestational age-dependent manner. Hum Reprod 2014; 29(6): 1161-72.
[http://dx.doi.org/10.1093/humrep/deu046] [PMID: 24626803]
[80]
Ferreira G, Blasina F, Rodríguez Rey M, et al. Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases. Biochim Biophys Acta Mol Basis Dis 2022; 1868(1): 166285.
[http://dx.doi.org/10.1016/j.bbadis.2021.166285] [PMID: 34624499]
[81]
Abbas-Hanif A, Rezai H, Ahmed SF, Ahmed A. The Impact of COVID-19 on Pregnancy and Therapeutic Drug Development. Br J Pharmacol 2022; 179(10): 2108-20.
[http://dx.doi.org/10.1111/bph.15582] [PMID: 34085281]
[82]
Marzoog B. Anticoagulant status under COVID-19: The potential pathophysiological mechanism. J App Hematoly 2022; 13(4): 167.
[http://dx.doi.org/10.4103/joah.joah_154_21]
[83]
Organizm Women in Pregnancy: Extragenital Changes (Obzor Literature). In: Federal State Unitary Enterprise «Izdatelstvo Sibirskogo otsadeniya Rossiiskoi Akademii Nauk» 2005.
[84]
Madjunkov M, Dviri M, Librach C. A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective. J Ovarian Res 2020; 13(1): 140.
[http://dx.doi.org/10.1186/s13048-020-00737-1]
[85]
Shatunova PO, Bykov AS, Svitich OA, Zverev VV. Angiotensin-converting enzyme 2. Approaches to pathogenetic therapy of COVID-19. Journal of microbiology, epidemiology and immunobiology 2020; 97(4): 339-45.
[http://dx.doi.org/10.36233/0372-9311-2020-97-4-6]
[86]
Allotey J, Fernandez S, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020; 370: m3320.
[http://dx.doi.org/10.1136/bmj.m3320] [PMID: 32873575]
[87]
Vousden N, Bunch K, Morris E, et al. The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS). PLoS One 2021; 16(5): e0251123.
[http://dx.doi.org/10.1371/journal.pone.0251123] [PMID: 33951100]
[88]
Laresgoiti-Servitje E, Cardona-Pérez JA, Hernández-Cruz RG. COVID-19 infection in pregnancy: PCR cycle thresholds, placental pathology, and perinatal outcomes. Viruses 2021; 13(9): 188.
[http://dx.doi.org/10.3390/v13091884]
[89]
Şahi̇n D, Tanaçan A, Webster SNE, Moraloğlu Teki̇n Ö. Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. Turk J Med Sci 2021; 51(SI-1): 3312-26.
[http://dx.doi.org/10.3906/sag-2106-134]
[90]
Karasek D, Baer RJ, McLemore MR, et al. The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California. Lancet Regional Health - Americas 2021; 2: 100027.
[http://dx.doi.org/10.1016/j.lana.2021.100027] [PMID: 34642685]
[91]
Nana M, Nelson-Piercy C. COVID-19 in Pregnancy. Clin Med 2021; 21(5): e446.
[http://dx.doi.org/10.7861/clinmed.2021-0503]
[92]
Yan J, Guo J, Fan C, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol 2020; 223(1): 111.e1-111.e14.
[http://dx.doi.org/10.1016/j.ajog.2020.04.014] [PMID: 32335053]
[93]
Eleje GU, Ugwu EO, Enebe JT, et al. Cesarean section rate and outcomes during and before the first wave of COVID-19 pandemic. SAGE Open Med 2022; 10
[http://dx.doi.org/10.1177/20503121221085453] [PMID: 35342633]
[94]
Bandyopadhyay D, Akhtar T, Hajra A, et al. COVID-19 Pandemic: Cardiovascular Complications and Future Implications. Am J Cardiovasc Drugs 2020; 20(4): 311-24.
[http://dx.doi.org/10.1007/s40256-020-00420-2] [PMID: 32578167]
[95]
Mitrani RD, Dabas N, Goldberger JJ. COVID-19 cardiac injury: Implications for long-term surveillance and outcomes in survivors. Heart Rhythm 2020; 17(11): 1984-90.
[http://dx.doi.org/10.1016/j.hrthm.2020.06.026] [PMID: 32599178]
[96]
Juusela A, Nazir M, Gimovsky M. Two cases of coronavirus 2019–related cardiomyopathy in pregnancy. Am J Obstet Gynecol MFM 2020; 2(2): 100113.
[http://dx.doi.org/10.1016/j.ajogmf.2020.100113] [PMID: 32363336]
[97]
Hammad WAB, Al Beloushi M, Ahmed B, Konje JC. Severe acute respiratory syndrome (SARS) coronavirus-2 infection (COVID-19) in pregnancy – An overview. Eur J Obstet Gynecol Reprod Biol 2021; 263: 106-16.
[http://dx.doi.org/10.1016/j.ejogrb.2021.06.001] [PMID: 34225131]
[98]
Karimi-Zarchi M, Schwartz DA, Bahrami R, et al. A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. J Turkish Soci Obstet Gynecol 2021; 18(3): 224-35.
[http://dx.doi.org/10.4274/tjod.galenos.2021.66750] [PMID: 34580872]
[99]
Rosenbloom JI, Raghuraman N, Carter EB, Kelly JC. Coronavirus disease 2019 infection and hypertensive disorders of pregnancy. Am J Obstet Gynecol 2021; 224(6): 623-4.
[http://dx.doi.org/10.1016/j.ajog.2021.03.001] [PMID: 33675794]
[100]
Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand 2020; 99(7): 823-9.
[http://dx.doi.org/10.1111/aogs.13867] [PMID: 32259279]
[101]
Dashraath P, Wong JLJ, Lim MXK, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol 2020; 222(6): 521-31.
[http://dx.doi.org/10.1016/j.ajog.2020.03.021] [PMID: 32217113]
[102]
Di Mascio D, Buca D, Berghella V, et al. Counseling in maternal–fetal medicine: SARS-COV-2 infection in pregnancy. Ultrasound Obstet Gynecol 2021; 57(5): 687-97.
[http://dx.doi.org/10.1002/uog.23628] [PMID: 33724545]
[103]
Siddiqui S, Najam R. Pregnancy outcomes with COVID-19 lessons learned from the pandemic. Cureus 2021; 13(7): e16358.
[http://dx.doi.org/10.7759/cureus.16358] [PMID: 34395135]
[104]
DeBolt CA, Bianco A, Limaye MA, et al. Pregnant women with severe or critical coronavirus disease 2019 have increased composite morbidity compared with nonpregnant matched controls. Am J Obstet Gynecol 2021; 224(5): 510.e1-510.e12.
[http://dx.doi.org/10.1016/j.ajog.2020.11.022] [PMID: 33221292]
[105]
Jafari M, Pormohammad A, Sheikh Neshin SA, et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis. Rev Med Virol 2021; 31(5): 1-16.
[http://dx.doi.org/10.1002/rmv.2208] [PMID: 33387448]
[106]
Molteni E, Astley CM, Ma W, et al. SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology. medRxiv 2020; 2020.08.17.20161760.
[http://dx.doi.org/10.1101/2020.08.17.20161760]
[107]
Adhikari EH, Moreno W, Zofkie AC, et al. Pregnancy outcomes among women with and without severe acute respiratory syndrome coronavirus 2 infection. JAMA Netw Open 2020; 3(11): e2029256.
[http://dx.doi.org/10.1001/jamanetworkopen.2020.29256] [PMID: 33211113]
[108]
Vergara-Merino L, Meza N, Couve-Pérez C, et al. Maternal and perinatal outcomes related to COVID-19 and pregnancy: An overview of systematic reviews. Acta Obstet Gynecol Scand 2021; 100(7): 1200-18.
[http://dx.doi.org/10.1111/aogs.14118] [PMID: 33560530]
[109]
Taghavi SA, Heidari S, Jahanfar S, et al. Obstetric, maternal, and neonatal outcomes in COVID-19 compared to healthy pregnant women in Iran: a retrospective, case-control study. Middle East Fertil Soc J 2021; 26(1): 17.
[http://dx.doi.org/10.1186/s43043-021-00059-2] [PMID: 34149282]
[110]
Edlow AG, Li JZ, Collier AY, et al. Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. JAMA Netw Open 2020; 3(12): e2030455.
[http://dx.doi.org/10.1001/jamanetworkopen.2020.30455] [PMID: 33351086]
[111]
Delahoy MJ, Whitaker M, O’Halloran A, et al. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19 — COVID-NET, 13 States, March 1–August 22, 2020. MMWR Morb Mortal Wkly Rep 2020; 69(38): 1347-54.
[http://dx.doi.org/10.15585/mmwr.mm6938e1] [PMID: 32970655]
[112]
Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol 2020; 37(8): 861-5.
[http://dx.doi.org/10.1055/s-0040-1710050] [PMID: 32305046]
[113]
SeyedAlinaghi S, Mirzapour P, Dadras O, et al. Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review. Eur J Med Res 2021; 26(1): 51.
[http://dx.doi.org/10.1186/s40001-021-00524-8] [PMID: 34103090]
[114]
SeyedAlinaghi S, Afsahi AM, MohsseniPour M, et al. Late complications of COVID-19; a systematic review of current evidence. Arch Acad Emerg Med 2021; 9(1): e14-4.
[http://dx.doi.org/10.22037/AAEM.V9I1.1058] [PMID: 33681819]
[115]
Marzoog BA. Coagulopathy and brain injury pathogenesis in post-covid-19 syndrome. Cardiovasc Hematol Agents Med Chem 2022; 20(3): 178-88.
[http://dx.doi.org/10.2174/1871525720666220405124021] [PMID: 35382728]
[116]
Vouga M, Favre G, Martinez-Perez O, et al. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Sci Rep 2021; 11(1): 13898.
[http://dx.doi.org/10.1038/s41598-021-92357-y] [PMID: 34230507]
[117]
Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 2020; 368: m1091.
[http://dx.doi.org/10.1136/bmj.m1091] [PMID: 32217556]
[118]
Grechukhina O, Greenberg V, Lundsberg LS, et al. Coronavirus disease 2019 pregnancy outcomes in a racially and ethnically diverse population. Am J Obstet Gynecol MFM 2020; 2(4): 100246.
[http://dx.doi.org/10.1016/j.ajogmf.2020.100246] [PMID: 33047100]

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