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Therapeutic Potential of Gut Microbiota in Child Health

Author(s): Ratnadeep Bhattacharjee, Kalyani Pathak*, Jyotirmoy Das, Smita Bordoloi, Manash Pratim Pathak, Pervej Alom Barbhuiya and Riya Saikia

Volume 21, Issue 4, 2023

Published on: 09 August, 2023

Article ID: e180523217048 Pages: 9

DOI: 10.2174/2211352521666230518115214

Price: $65

Abstract

Gut or intestinal microbiota inhabit our body and are well nurtured by the body’s ambiance of its preference. Gut microorganisms include bacteria, archae, and fungi that primarily inhabit the digestive tracts of animals. Bacteria like Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 have been studied on a wide scale for their potential therapeutic applications. These bacteria are used as probiotics, most often as dietary supplements. They increase the population of the gut microbiota required for normal metabolic activities of the body. Recently, efforts have been made to analyze the effects of these probiotics and gut microbiota in the treatment of various diseases in children. In recent years, research has been conducted to investigate the effects of probiotics and microbiota in the gut on the prevention and treatment of a wide range of childhood disorders. Studies have been carried out to investigate the gut microbiota's effects on the function of beta cells in children recently diagnosed with type 1 diabetes. In this review article, a few applications and research of microbiota on children have been highlighted.

Graphical Abstract

[1]
Mishra, S.; Wang, S.; Nagpal, R.; Miller, B.; Singh, R.; Taraphder, S.; Yadav, H. Probiotics and prebiotics for the amelioration of type 1 diabetes: Present and future perspectives. Microorganisms, 2019, 7(3), 67.
[http://dx.doi.org/10.3390/microorganisms7030067] [PMID: 30832381]
[2]
(a) Qin, J.; Li, R.; Raes, J.; Arumugam, M.; Burgdorf, K.; Manichanh, C. A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 2010, 464(7285), 59-65.
[http://dx.doi.org/10.1038/nature08821];
(b) Rio, M.E.; Zago, L.B.; Garcia, H. [Influence of nutritional status on the effectiveness of a dietary supplement of live lactobacillus to prevent and cure diarrhoea in children]. Arch. Latinoam. Nutr., 2004, 54(3), 287-292.
[3]
Schwiertz, A.; Taras, D.; Schäfer, K.; Beijer, S.; Bos, N.A.; Donus, C.; Hardt, P.D. Microbiota and SCFA in lean and overweight healthy subjects. Obesity, 2010, 18(1), 190-195.
[http://dx.doi.org/10.1038/oby.2009.167] [PMID: 19498350]
[4]
Han, H.; Li, Y.; Fang, J.; Liu, G.; Yin, J.; Li, T.; Yin, Y. Gut microbiota and type 1 diabetes. Int. J. Mol. Sci., 2018, 19(4), 995.
[http://dx.doi.org/10.3390/ijms19040995] [PMID: 29584630]
[5]
Del Chierico, F.; Rapini, N.; Deodati, A.; Matteoli, M.C.; Cianfarani, S.; Putignani, L. Pathophysiology of type 1 diabetes and gut microbiota role. Int. J. Mol. Sci., 2022, 23(23), 14650.
[http://dx.doi.org/10.3390/ijms232314650] [PMID: 36498975]
[6]
Nissle, A. [Old and new experiences on therapeutic successes by restoration of the colonic flora with mutaflor in gastrointestinal diseases]. Med. Welt, 1961, 29-30, 1519-1523.
[PMID: 13729275]
[7]
Draper, K.; Ley, C.; Parsonnet, J. A survey of probiotic use practices among patients at a tertiary medical centre. Benef. Microbes, 2017, 8(3), 345-351.
[http://dx.doi.org/10.3920/BM2016.0148] [PMID: 28403649]
[8]
Selders, G.S.; Fetz, A.E.; Radic, M.Z.; Bowlin, G.L. An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration. Regen. Biomater., 2017, 4(1), 55-68.
[http://dx.doi.org/10.1093/rb/rbw041] [PMID: 28149530]
[9]
Lozupone, C.A.; Stombaugh, J.I.; Gordon, J.I.; Jansson, J.K.; Knight, R. Diversity, stability and resilience of the human gut microbiota. Nature, 2012, 489(7415), 220-230.
[http://dx.doi.org/10.1038/nature11550] [PMID: 22972295]
[10]
Adak, A.; Khan, M.R. An insight into gut microbiota and its functionalities. Cell. Mol. Life Sci., 2019, 76(3), 473-493.
[http://dx.doi.org/10.1007/s00018-018-2943-4] [PMID: 30317530]
[11]
Baas-Becking, L.G.M. Geobiologie; of inleiding tot de milieukunde. In: Dutch; W.P. Van Stockum & Zoon, Den Haag, 1934.
[12]
Nardone, G.; Compare, D. The human gastric microbiota: Is it time to rethink the pathogenesis of stomach diseases? United European Gastroenterol. J., 2015, 3(3), 255-260.
[http://dx.doi.org/10.1177/2050640614566846] [PMID: 26137299]
[13]
Mariat, D.; Firmesse, O.; Levenez, F.; Guimarăes, V.D.; Sokol, H.; Doré, J.; Corthier, G.; Furet, J-P. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol., 2009, 9(1), 123.
[http://dx.doi.org/10.1186/1471-2180-9-123] [PMID: 19508720]
[14]
Groussin, M.; Mazel, F.; Alm, E.J. Co-evolution and co-speciation of host-gut bacteria systems. Cell Host Microbe, 2020, 28(1), 12-22.
[http://dx.doi.org/10.1016/j.chom.2020.06.013] [PMID: 32645351]
[15]
Lombard, V.; Golaconda, R.H.; Drula, E.; Coutinho, P.M.; Henrissat, B. The carbohydrate-active enzymes database (CAZy) in 2013. Nucleic Acids Res., 2014, 42(D1), D490-D495.
[http://dx.doi.org/10.1093/nar/gkt1178] [PMID: 24270786]
[16]
Clark, J.A.; Coopersmith, C.M. Intestinal crosstalk: A new paradigm for understanding the gut as the “motor” of critical illness. Shock, 2007, 28(4), 384-393.
[http://dx.doi.org/10.1097/shk.0b013e31805569df] [PMID: 17577136]
[17]
Sarkar, A.; Lehto, S.M.; Harty, S.; Dinan, T.G.; Cryan, J.F.; Burnet, P.W.J. Psychobiotics and the manipulation of bacteria–gut–brain signals. Trends Neurosci., 2016, 39(11), 763-781.
[http://dx.doi.org/10.1016/j.tins.2016.09.002] [PMID: 27793434]
[18]
Knip, M.; Siljander, H. The role of the intestinal microbiota in type 1 diabetes mellitus. Nat. Rev. Endocrinol., 2016, 12(3), 154-167.
[http://dx.doi.org/10.1038/nrendo.2015.218] [PMID: 26729037]
[19]
Fraher, M.H.; O’Toole, P.W.; Quigley, E.M.M. Techniques used to characterize the gut microbiota: A guide for the clinician. Nat. Rev. Gastroenterol. Hepatol., 2012, 9(6), 312-322.
[http://dx.doi.org/10.1038/nrgastro.2012.44] [PMID: 22450307]
[20]
Kankainen, M.; Paulin, L.; Tynkkynen, S.; von Ossowski, I.; Reunanen, J.; Partanen, P.; Satokari, R.; Vesterlund, S.; Hendrickx, A.P.A.; Lebeer, S.; De Keersmaecker, S.C.J.; Vanderleyden, J.; Hämäläinen, T.; Laukkanen, S.; Salovuori, N.; Ritari, J.; Alatalo, E.; Korpela, R.; Mattila-Sandholm, T.; Lassig, A.; Hatakka, K.; Kinnunen, K.T.; Karjalainen, H.; Saxelin, M.; Laakso, K.; Surakka, A.; Palva, A.; Salusjärvi, T.; Auvinen, P.; de Vos, W.M. Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus bind-ing protein. Proc. Natl. Acad. Sci., 2009, 106(40), 17193-17198.
[http://dx.doi.org/10.1073/pnas.0908876106] [PMID: 19805152]
[21]
Conway, P.L.; Gorbach, S.L.; Goldin, B.R. Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells. J. Dairy Sci., 1987, 70(1), 1-12.
[http://dx.doi.org/10.3168/jds.S0022-0302(87)79974-3] [PMID: 3106442]
[22]
Ceapa, C.; Davids, M.; Ritari, J.; Lambert, J.; Wels, M.; Douillard, F.P.; Smokvina, T.; de Vos, W.M.; Knol, J.; Kleerebezem, M. The variable regions of lactobacillus rhamnosus genomes reveal the dynamic evolution of metabolic and host-adaptation repertoires. Genome Biol. Evol., 2016, 8(6), 1889-1905.
[http://dx.doi.org/10.1093/gbe/evw123] [PMID: 27358423]
[23]
Sales-Campos, H.; Soares, S.C.; Oliveira, C.J.F. An introduction of the role of probiotics in human infections and autoimmune diseases. Crit. Rev. Microbiol., 2019, 45(4), 413-432.
[http://dx.doi.org/10.1080/1040841X.2019.1621261] [PMID: 31157574]
[24]
Lawrence, J.M.; Divers, J.; Isom, S.; Saydah, S.; Imperatore, G.; Pihoker, C.; Marcovina, S.M.; Mayer-Davis, E.J.; Hamman, R.F.; Dolan, L.; Dabelea, D.; Pettitt, D.J.; Liese, A.D. Trends in prevalence of type 1 and type 2 diabetes in children and adolescents in the US, 2001–2017. JAMA, 2021, 326(8), 717-727.
[http://dx.doi.org/10.1001/jama.2021.11165] [PMID: 34427600]
[25]
Streisand, R.; Monaghan, M. Young children with type 1 diabetes: Challenges, research, and future directions. Curr. Diab. Rep., 2014, 14(9), 520.
[http://dx.doi.org/10.1007/s11892-014-0520-2] [PMID: 25009119]
[26]
Jamshidi, P.; Hasanzadeh, S.; Tahvildari, A.; Farsi, Y.; Arbabi, M.; Mota, J.F.; Sechi, L.A.; Nasiri, M.J. Is there any association between gut microbiota and type 1 diabetes? A systematic review. Gut Pathog., 2019, 11(1), 49.
[http://dx.doi.org/10.1186/s13099-019-0332-7] [PMID: 31636716]
[27]
(a) Weizman, Z.; Asli, G.; Alsheikh, A. Effect of a probiotic infant formula on infections in child care centers: Comparison of two probiotic agents. Pediatrics, 2005, 115(1), 5-9.2005.
[http://dx.doi.org/10.1542/peds.2004-1815];
(b) Weston, S. Effects of probiotics on atopic dermatitis: A randomised controlled trial. Arch. Dis. Child., 2005, 90(9), 892-897.
[28]
Sarker, S.A.; Sultana, S.; Fuchs, G.J.; Alam, N.H.; Azim, T.; Brüssow, H.; Hammarström, L. Lactobacillus paracasei strain ST11 has no effect on rotavirus but ameliorates the outcome of nonrotavirus diarrhea in children from Bangladesh. Pediatrics, 2005, 116(2), e221-e228.
[http://dx.doi.org/10.1542/peds.2004-2334] [PMID: 15995003]
[29]
Szajewska, H.; Ruszczyński, M.; Radzikowski, A. Probiotics in the prevention of antibiotic-associated diarrhea in children: A meta-analysis of randomized controlled trials. J. Pediatr., 2006, 149(3), 367-372.e1.
[http://dx.doi.org/10.1016/j.jpeds.2006.04.053] [PMID: 16939749]
[30]
Laursen, R.P.; Larnkjær, A.; Ritz, C.; Hauger, H.; Michaelsen, K.F.; Mølgaard, C. Probiotics and child care absence due to infections: A randomized controlled trial. Pediatrics, 2017, 140(2), e20170735.
[http://dx.doi.org/10.1542/peds.2017-0735] [PMID: 28674113]
[31]
Sazawal, S.; Hiremath, G.; Dhingra, U.; Malik, P.; Deb, S.; Black, R.E. Efficacy of probiotics in prevention of acute diarrhoea: A meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect. Dis., 2006, 6(6), 374-382.
[http://dx.doi.org/10.1016/S1473-3099(06)70495-9] [PMID: 16728323]
[32]
Johnston, B.C.; Supina, A.L.; Vohra, S. Probiotics for pediatric antibiotic-associated diarrhea: A meta-analysis of randomized placebo-controlled trials. CMAJ, 2006, 175(4), 377-383.
[http://dx.doi.org/10.1503/cmaj.051603] [PMID: 16908901]
[33]
Kligler, B.; Hanaway, P.; Cohrssen, A. Probiotics in children. Pediatr. Clin. North Am., 2007, 54(6), 949-967. xi.
[http://dx.doi.org/10.1016/j.pcl.2007.10.002] [PMID: 18061785]
[34]
Szymański, H.; Pejcz, J.; Jawień, M.; Chmielarczyk, A.; Strus, M.; Heczko, P.B. Treatment of acute infectious diarrhoea in infants and chil-dren with a mixture of three Lactobacillus rhamnosus strains - a randomized, double-blind, placebo-controlled trial. Aliment. Pharmacol. Ther., 2006, 23(2), 247-253.
[http://dx.doi.org/10.1111/j.1365-2036.2006.02740.x] [PMID: 16393304]
[35]
Billoo, A.G.; Memon, M.A.; Khaskheli, S.A.; Murtaza, G.; Iqbal, K.; Saeed Shekhani, M.; Siddiqi, A.Q. Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea. World J. Gastroenterol., 2006, 12(28), 4557-4560.
[http://dx.doi.org/10.3748/wjg.v12.i28.4557] [PMID: 16874872]
[36]
Oberhelman, R.A.; Gilman, R.H.; Sheen, P.; Taylor, D.N.; Black, R.E.; Cabrera, L.; Lescano, A.G.; Meza, R.; Madico, G. A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children. J. Pediatr., 1999, 134(1), 15-20.
[http://dx.doi.org/10.1016/S0022-3476(99)70366-5] [PMID: 9880443]
[37]
Chouraqui, J.P.J.; Van Egroo, L.D.L.; Fichot, M.C.M. Does a probiotic added to an infant acidified formula prevent diarrhea? A multicenter controlled trial. Gastroenterology, 2000, 118(4), A852.
[http://dx.doi.org/10.1016/S0016-5085(00)85552-3]
[38]
Thibault, H.; Aubert-Jacquin, C.; Goulet, O. Effects of long-term consumption of a fermented infant formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on acute diarrhea in healthy infants. J. Pediatr. Gastroenterol. Nutr., 2004, 39(2), 147-152.
[http://dx.doi.org/10.1097/00005176-200408000-00004] [PMID: 15269618]
[39]
Bin-Nun, A.; Bromiker, R.; Wilschanski, M.; Kaplan, M.; Rudensky, B.; Caplan, M.; Hammerman, C. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J. Pediatr., 2005, 147(2), 192-196.
[http://dx.doi.org/10.1016/j.jpeds.2005.03.054] [PMID: 16126048]
[40]
Lin, H.C.; Su, B.H.; Chen, A.C.; Lin, T.W.; Tsai, C.H.; Yeh, T.F.; Oh, W. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics, 2005, 115(1), 1-4.
[http://dx.doi.org/10.1542/peds.2004-1463] [PMID: 15629973]
[41]
Bausserman, M.; Michail, S. The use of Lactobacillus GG in irritable bowel syndrome in children: A double-blind randomized control trial. J. Pediatr., 2005, 147(2), 197-201.
[http://dx.doi.org/10.1016/j.jpeds.2005.05.015] [PMID: 16126049]
[42]
Banaszkiewicz, A.; Szajewska, H. Ineffectiveness of Lactobacillus GG as an adjunct to lactulose for the treatment of constipation in children: A double-blind, placebo-controlled randomized trial. J. Pediatr., 2005, 146(3), 364-369.
[http://dx.doi.org/10.1016/j.jpeds.2004.10.022] [PMID: 15756221]
[43]
Savino, F.; Pelle, E.; Palumeri, E.; Oggero, R.; Miniero, R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: A prospective randomized study. Pediatrics, 2007, 119(1), e124-e130.
[http://dx.doi.org/10.1542/peds.2006-1222] [PMID: 17200238]
[44]
Kalliomäki, M.; Salminen, S.; Arvilommi, H.; Kero, P.; Koskinen, P.; Isolauri, E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet, 2001, 357(9262), 1076-1079.
[http://dx.doi.org/10.1016/S0140-6736(00)04259-8] [PMID: 11297958]
[45]
Taylor, A.L.; Dunstan, J.A.; Prescott, S.L. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial. J. Allergy Clin. Immunol., 2007, 119(1), 184-191.
[http://dx.doi.org/10.1016/j.jaci.2006.08.036] [PMID: 17208600]
[46]
Miura, K.; Ohnishi, H. Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease. World J. Gastroenterol., 2014, 20(23), 7381-7391.
[http://dx.doi.org/10.3748/wjg.v20.i23.7381] [PMID: 24966608]
[47]
Tilg, H.; Cani, P.D.; Mayer, E.A. Gut microbiome and liver diseases. Gut, 2016, 65(12), 2035-2044.
[http://dx.doi.org/10.1136/gutjnl-2016-312729] [PMID: 27802157]
[48]
Song, W.; Sun, L.Y.; Zhu, Z.J.; Wei, L.; Qu, W.; Zeng, Z.G.; Yang, Y.S. Characteristics of gut microbiota in children with biliary atresia after liver transplantation. Front. Physiol., 2021, 12, 704313.
[http://dx.doi.org/10.3389/fphys.2021.704313] [PMID: 34262484]
[49]
De Groote, M.A.; Frank, D.N.; Dowell, E.; Glode, M.P.; Pace, N.R. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr. Infect. Dis. J., 2005, 24(3), 278-280.
[http://dx.doi.org/10.1097/01.inf.0000154588.79356.e6] [PMID: 15750472]
[50]
Srinivasan, R.; Meyer, R.; Padmanabhan, R.; Britto, J. Clinical safety of Lactobacillus casei shirota as a probiotic in critically ill children. J. Pediatr. Gastroenterol. Nutr., 2006, 42(2), 171-173.
[http://dx.doi.org/10.1097/01.mpg.0000189335.62397.cf] [PMID: 16456410]
[51]
Hammerman, C.; Bin-Nun, A.; Kaplan, M. Safety of probiotics: Comparison of two popular strains. BMJ, 2006, 333(7576), 1006-1008.
[http://dx.doi.org/10.1136/bmj.39010.630799.53]

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