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New Emirates Medical Journal

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ISSN (Online): 0250-6882

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Research Article

Type 1 Diabetes Mellitus Clinical Profile and Follow-up: North Emirate Hospitals’ Experience

Author(s): Ghofran Osman, Areen Yousef, Malay Jhancy*, Sarmini Dana and Subhranshu Sekhar Kar

Volume 4, Issue 2, 2023

Published on: 18 July, 2023

Article ID: e080523216645 Pages: 5

DOI: 10.2174/0250688204666230508115858

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Abstract

Background: Type 1 Diabetes mellitus (DM) is a chronic metabolic disorder in children and adolescents due to insulin deficiency. The disease is more common below 19 years of age with two peaks of incidence, one at 4-6 years and the other peak at early puberty (10-14 years). There is a gradual increase in the incidence of type 1 DM and a rise in incidence at 10,200 cases per year in the Middle East. Chronic type-1 diabetic patients develop microvascular and macrovascular complications.

Methods: The present retrospective cross-sectional study aims to describe the experience on the clinical profile, morbidity profile, and comorbidities of Type1 DM in children below 15 years of age admitted to the SAQR and Fujairah hospitals in the Northern part of United Arab Emirates (UAE) from 1st January 2017 to 31st December 2019. The study material was the digital medical records of children below 15 years who got admitted to emergency and pediatric wards with type 1 Diabetes mellitus (T1DM) in SAQR and Fujairah hospitals.

Results: Total admissions during the study period were 98. At the time of diagnosis, 12.2% of children were below five years of age, whereas 87.75% were more than five years. All 98 children were UAE nationals, of which 52% were males and 48% were females. 50% of our study population has a strong family history of either type 1 or type 2 diabetes mellitus, of which 12.2% of siblings of the study population had T1DM. The first symptoms in 58% and 57% of children were polyuria and polydipsia. Among 90% of children under follow-up for three years, one child developed microalbuminuria, three developed systolic hypertension, and 8% were lost to follow-up.

Conclusion: The present study highlights the need for future prospective studies in the UAE to know the actual burden of the disease with an emphasis on early screening.

[1]
Katsarou A, Gudbjörnsdottir S, Rawshani A, et al. Type 1 diabetes mellitus. Nat Rev Dis Primers 2017; 3(1): 17016.
[http://dx.doi.org/10.1038/nrdp.2017.16] [PMID: 28358037]
[2]
Lynne LL. Management of type1 diabetes mellitus in children and adolescents. Literature review 2019.
[3]
IDF diabetes atlas. (7th ed.), International Diabetes Federation 2015.
[4]
Robert AA, Al-Dawish A, Mujammami M, Dawish MAA. Type 1 diabetes mellitus in Saudi Arabia: A soaring epidemic. Int J Pediatr 2018; 2018: 1-9.
[http://dx.doi.org/10.1155/2018/9408370] [PMID: 29853923]
[5]
UAE Population Statistics in 2019 (Infographics). GMI 2019. Available from: https://www.globalmediainsight.com
[6]
Health statistics 2015, Health Authority Abudhabi. 2016. Available from: www.haad.ae/statistics2015-xl
[7]
American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care 2017; 40(S1): S11-24.
[http://dx.doi.org/10.2337/dc17-S005] [PMID: 27979889]
[8]
Melendez-Ramirez LY, Richards RJ, Cefalu WT. Complications of type 1 diabetes. Endocrinol Metab Clin North Am 2010; 39(3): 625-40.
[http://dx.doi.org/10.1016/j.ecl.2010.05.009] [PMID: 20723824]
[9]
Saydah SH, Imperatore G, Henkin L, et al. Trends and characteristics of self-reported case presentation of diabetes diagnosis among youth from 2002 to 2010: Findings from the SEARCH for diabetes in youth study. Diabetes Care 2015; 38(6): e84-5.
[http://dx.doi.org/10.2337/dc15-0157] [PMID: 25998301]
[10]
Nathan DM. The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: Overview. Diabetes Care 2014; 37(1): 9-16.
[http://dx.doi.org/10.2337/dc13-2112] [PMID: 24356592]
[11]
Anderzén J, Samuelsson U, Gudbjörnsdottir S, Hanberger L, Åkesson K. Teenagers with poor metabolic control already have a higher risk of microvascular complications as young adults. J Diabetes Complications 2016; 30(3): 533-6.
[http://dx.doi.org/10.1016/j.jdiacomp.2015.12.004] [PMID: 26775554]
[12]
Al-Maskari F, El-Sadig M. Prevalence of diabetic retinopathy in the United Arab Emirates: A cross-sectional survey. BMC Ophthalmol 2007; 7(1): 11.
[http://dx.doi.org/10.1186/1471-2415-7-11] [PMID: 17572909]
[13]
Raile K, Galler A, Hofer S, et al. Diabetic nephropathy in 27,805 children, adolescents, and adults with type 1 diabetes: effect of diabetes duration, A1C, hypertension, dyslipidemia, diabetes onset, and sex. Diabetes Care 2007; 30(10): 2523-8.
[http://dx.doi.org/10.2337/dc07-0282] [PMID: 17630266]
[14]
Gross JL, de Azevedo MJ, Silveiro SP, Canani LH, Caramori ML, Zelmanovitz T. Diabetic nephropathy: Diagnosis, prevention, and treatment. Diabetes Care 2005; 28(1): 164-76.
[http://dx.doi.org/10.2337/diacare.28.1.164] [PMID: 15616252]
[15]
Al-Maskari F, El-Sadig M, Obineche E. Prevalence and determinants of microalbuminuria among diabetic patients in the United Arab Emirates. BMC Nephrol 2008; 9(1): 1.
[http://dx.doi.org/10.1186/1471-2369-9-1] [PMID: 18230135]
[16]
Gerstein HC. Dysglycaemia as a cause of cardiovascular outcomes. Nat Rev Endocrinol 2015; 11(9): 508-10.
[http://dx.doi.org/10.1038/nrendo.2015.118] [PMID: 26215261]
[17]
Al-Maskari F, El-Sadig M, Norman JN. The prevalence of macrovascular complications among diabetic patients in the United Arab Emirates. Cardiovasc Diabetol 2007; 6(1): 24.
[http://dx.doi.org/10.1186/1475-2840-6-24] [PMID: 17880686]
[18]
Jelinek HF, Osman WM, Khandoker AH, et al. Clinical profiles, comorbidities and complications of type 2 diabetes mellitus in patients from United Arab Emirates. BMJ Open Diabetes Res Care 2017; 5(1): e000427.
[http://dx.doi.org/10.1136/bmjdrc-2017-000427] [PMID: 28878941]
[19]
Fazeli Farsani S, Souverein PC, van der Vorst MMJ, Knibbe CAJ, de Boer A, Mantel-Teeuwisse AK. Chronic comorbidities in children with type 1 diabetes: A population-based cohort study. Arch Dis Child 2015; 100(8): 763-8.
[http://dx.doi.org/10.1136/archdischild-2014-307654] [PMID: 25877155]
[20]
Britta M, Nicholas J. classification of diabetes mellitus, Nelson textbook of pediatrics. (20th ed.). 2761.
[21]
Parkkola A, Härkönen T, Ryhänen SJ, Ilonen J, Knip M. Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children. Diab Care 2013; 36(2): 348-54.
[http://dx.doi.org/10.2337/dc12-0445] [PMID: 23033245]
[22]
Turtinen M, Härkönen T, Parkkola A, Ilonen J, Knip M. Characteristics of familial type 1 diabetes: Effects of the relationship to the affected family member on phenotype and genotype at diagnosis. Diabetologia 2019; 62(11): 2025-39.
[http://dx.doi.org/10.1007/s00125-019-4952-8] [PMID: 31346657]

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