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The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Review Article

Herbal Components for the Treatment of Various Kidney Disorders

Author(s): Javed Khan, Shikha Yadav* and Md. Aftab Alam

Volume 14, Issue 1, 2024

Published on: 19 May, 2023

Article ID: e180423215970 Pages: 12

DOI: 10.2174/2210315513666230418104500

Price: $65

Abstract

Acute kidney injury is described as a loss of renal excretory function that occurs suddenly. AKI is one of several ailments grouped together as acute kidney diseases and disorders (AKD), in which progressive degradation of kidney function or persistent renal dysfunction is associated with irreversible loss of kidney cells and nephrons, potentially leading to chronic kidney disease (CKD). The prevalence and incidence of KDs are assessed in light of population disparities in the prevalence of risk factors such as diabetes, hypertension, and obesity. However, the presence of these associated illnesses does not fully explain the increased rate of progression of chronic renal disease in high-risk patients (CKD). The development of renal disease is accompanied by a decline in renal function, which eventually leads to renal failure. The current status of diagnostic testing does not allow for accurate early disease diagnosis, prognosis, or therapy efficacy monitoring. Despite significant advances in care and understanding of the causes of acute renal failure (ARF), many aspects of ARF remain controversial, confusing, and uncertain. Accurate information on the disease's prevalence, genesis, and clinical manifestations is required to successfully advocate for enough funding and resources to manage the disease. Herbal components for the treatment of a variety of kidney disorders, and the page includes a list of plants that are good for kidney treatment. This review focuses on several herbal products used to treat renal problems. It is clear from this study that medicinal plants play an important role in the fight against many different diseases. Several different plants and plant extracts have been shown to have beneficial effects in treating renal disease. These medications have great promise for use in treating kidney damage because of their nephroprotective, cytoprotective, immunomodulatory, antioxidant, anti-inflammatory, and reducing effects on oxidative stress, renal hypertension, and blood toxins such as urea, creatinine, and others. Therefore, India's traditional medicine offers a wide variety of medications that can be utilized in renal illnesses due to their effectiveness in both treating the ailment and restoring normal kidney function. Therefore, it is suggested that additional research be conducted to learn many aspects and mechanisms of medications.

Graphical Abstract

[1]
Muniz-Junqueira, M.I.; Braga Lopes, C.; Magalhães, C.A.M.; Schleicher, C.C.; Veiga, J.P.R. Acute and chronic influence of hemodialysis according to the membrane used on phagocytic function of neutrophils and monocytes and pro-inflammatory cytokines production in chronic renal failure patients. Life Sci., 2005, 77(25), 3141-3155.
[http://dx.doi.org/10.1016/j.lfs.2005.03.034] [PMID: 16005905]
[2]
Schlaich, M.P.; Socratous, F.; Hennebry, S.; Eikelis, N.; Lambert, E.A.; Straznicky, N.; Esler, M.D.; Lambert, G.W. Sympathetic activation in chronic renal failure. J. Am. Soc. Nephrol., 2009, 20(5), 933-939.
[http://dx.doi.org/10.1681/ASN.2008040402] [PMID: 18799718]
[3]
Jiang, S.; Chuang, P.Y.; Liu, Z.H.; He, J.C. The primary glomerulonephritides: A systems biology approach. Nat. Rev. Nephrol., 2013, 9(9), 500-512.
[http://dx.doi.org/10.1038/nrneph.2013.129] [PMID: 23856995]
[4]
Solhaug, M.J.; Bolger, P.M.; Jose, P.A. The developing kidney and environmental toxins. Pediatrics, 2004, 113(4)(Suppl. 3), 1084-1091.
[http://dx.doi.org/10.1542/peds.113.S3.1084] [PMID: 15060203]
[5]
Xu, X.; Nie, S.; Ding, H.; Hou, F.F. Environmental pollution and kidney diseases. Nat. Rev. Nephrol., 2018, 14(5), 313-324.
[http://dx.doi.org/10.1038/nrneph.2018.11] [PMID: 29479079]
[6]
Wedekin, M.; Ehrich, J.H.; Offner, G.; Pape, L. Aetiology and outcome of acute and chronic renal failure in infants. Nephrol. Dial. Transplant., 2008, 23(5), 1575-1580.
[http://dx.doi.org/10.1093/ndt/gfm863] [PMID: 18182406]
[7]
Bellomo, R.; Ronco, C.; Kellum, J.A.; Mehta, R.L.; Palevsky, P. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: The second international consensus conference of the acute dialysis quality initiative (ADQI) Group. Crit. Care, 2004, 8(4), R204-R212.
[http://dx.doi.org/10.1186/cc2872] [PMID: 15312219]
[8]
Cole, L.; Bellomo, R.; Silvester, W.; Reeves, J.H. Victorian severe acute renal failure study group a prospective, multicenter study of the epidemiology, management, and outcome of severe acute renal failure in a “Closed” ICU system. Am. J. Respir. Crit. Care Med., 2000, 162(1), 191-196.
[http://dx.doi.org/10.1164/ajrccm.162.1.9907016] [PMID: 10903628]
[9]
Schrier, R.W. Need to intervene in established acute renal failure. J. Am. Soc. Nephrol., 2004, 15(10), 2756-2758.
[http://dx.doi.org/10.1097/01.ASN.0000141324.49873.11] [PMID: 15466282]
[10]
Venkataraman, R.; Kellum, J.A. Defining acute renal failure: The RIFLE criteria. J. Intensive Care Med., 2007, 22(4), 187-193.
[http://dx.doi.org/10.1177/0885066607299510] [PMID: 17712054]
[11]
Bonventre, J.V. Mechanisms of ischemic acute renal failure. Kidney Int., 1993, 43(5), 1160-1178.
[http://dx.doi.org/10.1038/ki.1993.163] [PMID: 8510397]
[12]
Kaur, G.; Hussain, M.S.; Mohit, K.T. A review of acute or chronic renal failure, common kidney diseases, and herbal plants used for management. Int. J. Bot. Stud., 2021, 6, 50-56.
[13]
Bonventre, J.V.; Zuk, A. Ischemic acute renal failure: An inflammatory disease? Kidney Int., 2004, 66(2), 480-485.
[http://dx.doi.org/10.1111/j.1523-1755.2004.761_2.x] [PMID: 15253693]
[14]
Mehta, R.L.; Pascual, M.T.; Soroko, S.; Chertow, G.M. Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA, 2002, 288(20), 2547-2553.
[http://dx.doi.org/10.1001/jama.288.20.2547] [PMID: 12444861]
[15]
Converse, R.L., Jr; Jacobsen, T.N.; Toto, R.D.; Jost, C.M.T.; Cosentino, F.; Fouad-Tarazi, F.; Victor, R.G. Sympathetic overactivity in patients with chronic renal failure. N. Engl. J. Med., 1992, 327(27), 1912-1918.
[http://dx.doi.org/10.1056/NEJM199212313272704] [PMID: 1454086]
[16]
Silverberg, D.S.; Wexler, D.; Blum, M.; Keren, G.; Sheps, D.; Leibovitch, E.; Brosh, D.; Laniado, S.; Schwartz, D.; Yachnin, T.; Shapira, I.; Gavish, D.; Baruch, R.; Koifman, B.; Kaplan, C.; Steinbruch, S.; Iaina, A. The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J. Am. Coll. Cardiol., 2000, 35(7), 1737-1744.
[http://dx.doi.org/10.1016/S0735-1097(00)00613-6] [PMID: 10841219]
[17]
Samaké, M.; Sy, S.; Yattara, H.; Coulibaly, M.; Sanogo, M.B.; Fofana, A.S.; Dolo, A.M.; Maiga, D.; Diallo, D.; Kodio, A.; Diarra, B.; Djiguiba, K.; Sy, D.; Fongoro, S. Digestive pathologies during chronic renal failure in the nephrology and haemodialysis department at the university hospital center of point G in mali. Open J. Clin. Diagn., 2020, 10(1), 41-48.
[http://dx.doi.org/10.4236/ojcd.2020.101004]
[18]
Kaufman, J.M.; Hatzichristou, D.G.; Mulhall, J.P.; Fitch, W.P.; Goldstein, I. Impotence and chronic renal failure: A study of the hemodynamic pathophysiology. J. Urol., 1994, 151(3), 612-618.
[http://dx.doi.org/10.1016/S0022-5347(17)35030-9] [PMID: 8308970]
[19]
Daschner, M.; Tönshoff, B.; Blum, W.F.; Englaro, P.; Wingen, A.M.; Schaefer, F.; Wühl, E.; Rascher, W.; Mehls, O. Inappropriate elevation of serum leptin levels in children with chronic renal failure. J. Am. Soc. Nephrol., 1998, 9(6), 1074-1079.
[http://dx.doi.org/10.1681/ASN.V961074] [PMID: 9621291]
[20]
Ristikankare, A.; Kuitunen, T.; Kuitunen, A.; Uotila, L.; Vento, A.; Suojaranta-Ylinen, R.; Salmenperä, M.; Pöyhiä, R. Lack of renoprotective effect of i.v. N -acetylcysteine in patients with chronic renal failure undergoing cardiac surgery. Br. J. Anaesth., 2006, 97(5), 611-616.
[http://dx.doi.org/10.1093/bja/ael224] [PMID: 16914459]
[21]
Chukwu, C.A.; Middleton, R.; Kalra, P.A. Recurrent glomerulonephritis after renal transplantation. Curr. Opin. Nephrol. Hypertens., 2020, 29(6), 636-644.
[http://dx.doi.org/10.1097/MNH.0000000000000643] [PMID: 33009132]
[22]
Briganti, E.M.; Russ, G.R.; McNeil, J.J.; Atkins, R.C.; Chadban, S.J. Risk of renal allograft loss from recurrent glomerulonephritis. N. Engl. J. Med., 2002, 347(2), 103-109.
[http://dx.doi.org/10.1056/NEJMoa013036] [PMID: 12110738]
[23]
Mason, P.D.; Pusey, C.D. Fortnightly Review: Glomerulonephritis: Diagnosis and treatment. BMJ, 1994, 309(6968), 1557-1563.
[http://dx.doi.org/10.1136/bmj.309.6968.1557] [PMID: 7819900]
[24]
Hricik, D.E.; Chung-Park, M.; Sedor, J.R. Glomerulonephritis. N. Engl. J. Med., 1998, 339(13), 888-899.
[http://dx.doi.org/10.1056/NEJM199809243391306] [PMID: 9744974]
[25]
Ibraghimov-Beskrovnaya, O.; Bukanov, N. Polycystic kidney diseases: From molecular discoveries to targeted therapeutic strategies. Cell. Mol. Life Sci., 2008, 65(4), 605-619.
[http://dx.doi.org/10.1007/s00018-007-7362-x] [PMID: 17975706]
[26]
Igarashi, P.; Somlo, S. Genetics and pathogenesis of polycystic kidney disease. J. Am. Soc. Nephrol., 2002, 13(9), 2384-2398.
[http://dx.doi.org/10.1097/01.ASN.0000028643.17901.42] [PMID: 12191984]
[27]
Kaplan, B.S.; Kaplan, P.; Rosenberg, H.K.; Lamothe, E.; Rosenblatt, D.S. Polycystic kidney diseases in childhood. J. Pediatr., 1989, 115(6), 867-880.
[http://dx.doi.org/10.1016/S0022-3476(89)80735-8] [PMID: 2685218]
[28]
Wilson, P.D. Polycystic kidney disease. N. Engl. J. Med., 2004, 350(2), 151-164.
[http://dx.doi.org/10.1056/NEJMra022161] [PMID: 14711914]
[29]
Christensen, A.J.; Ehlers, S.L. Psychological factors in end-stage renal disease: An emerging context for behavioral medicine research. J. Consult. Clin. Psychol., 2002, 70(3), 712-724.
[http://dx.doi.org/10.1037/0022-006X.70.3.712] [PMID: 12090378]
[30]
Scales, C.D., Jr; Smith, A.C.; Hanley, J.M.; Saigal, C.S. Prevalence of kidney stones in the United States. Eur. Urol., 2012, 62(1), 160-165.
[http://dx.doi.org/10.1016/j.eururo.2012.03.052] [PMID: 22498635]
[31]
Alelign, T.; Petros, B. Kidney stone disease: An update on current concepts. Adv. Urol., 2018, 2018, 3068365.
[http://dx.doi.org/10.1155/2018/3068365]
[32]
Hussain, M.S.; Singh, M.; Kumar, B.; Tewari, D.; Mansoor, S.; Ganesh, N. Antimicrobial activity in ethanolic extracts of Bixa orellana L., Simarouba glauca DC and Ocimum tenuiflorum L. collected from JNCH herbal garden. World J. Pharm. Res., 2020, 9(4), 650-663.
[33]
Musabayane, C.T. The effects of medicinal plants on renal function and blood pressure in diabetes mellitus: Review article. Cardiovasc. J. Afr., 2012, 23(8), 462-468.
[http://dx.doi.org/10.5830/CVJA-2012-025] [PMID: 23044503]
[34]
Isnard Bagnis, C.; Deray, G.; Baumelou, A.; Le Quintrec, M.; Vanherweghem, J.L. Herbs and the kidney. Am. J. Kidney Dis., 2004, 44(1), 1-11.
[http://dx.doi.org/10.1053/j.ajkd.2004.02.009] [PMID: 15211432]
[35]
Karimi, M.; Naghdi, N.; Naji-Haddadi, S.; Bahmani, F. Medicinal plants used for kidney pain. J. Pharm. Sci. Res., 2017, 9(5), 542-546.
[36]
Li, L. Rheum officinale: A new lead in preventing progression of chronic renal failure. Chin. Med. J., 1996, 109(1), 35-37.
[PMID: 8758359]
[37]
Singh, P.; Negi, J.S.; Rawat, M.S.M. nee Pant, G.J. Quantification of mineral elements of Rheum emodi Wallr. (Polygonaceae). Biol. Trace Elem. Res., 2010, 138(1-3), 293-299.
[http://dx.doi.org/10.1007/s12011-009-8603-7] [PMID: 20084467]
[38]
Yokozawa, T.; Suzuki, N.; Zheng, P.D.; Oura, H.; Nishioka, I. Effect of orally administered rhubarb extract in rats with chronic renal failure. Chem. Pharm. Bull., 1984, 32(11), 4506-4513.
[http://dx.doi.org/10.1248/cpb.32.4506] [PMID: 6532552]
[39]
Yin, X.; Gong, X.; Jiang, R.; Kuang, G.; Wang, B.; Zhang, L.; Xu, G.; Wan, J. Emodin ameliorated lipopolysaccharide-induced fulminant hepatic failure by blockade of TLR4/MD2 complex expression in D-galactosamine-sensitized mice. Int. Immunopharmacol., 2014, 23(1), 66-72.
[http://dx.doi.org/10.1016/j.intimp.2014.08.018] [PMID: 25173984]
[40]
Zheng, J-M.; Zhu, J-M.; Li, L-S.; Liu, Z-H. Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway. Br. J. Pharmacol., 2008, 153(7), 1456-1464.
[http://dx.doi.org/10.1038/bjp.2008.26] [PMID: 18264122]
[41]
Zhang, G.; El Nahas, A.M. The effect of rhubarb extract on experimental renal fibrosis. Nephrol. Dial. Transplant., 1996, 11(1), 186-190.
[http://dx.doi.org/10.1093/oxfordjournals.ndt.a027039] [PMID: 8649632]
[42]
Gao, Q.; Qin, W.S.; Jia, Z.H.; Zheng, J.M.; Zeng, C.H.; Li, L.S.; Liu, Z.H. Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy. Planta Med., 2010, 76(1), 27-33.
[http://dx.doi.org/10.1055/s-0029-1185948] [PMID: 19639539]
[43]
Zhang, Z.C.; Li, S.J.; Yang, Y.Z.; Chen, R.Z.; Ge, J.B.; Chen, H.Z. Effect of astragaloside on cardiomyocyte apoptosis in murine coxsackievirus B3 myocarditis. J. Asian Nat. Prod. Res., 2007, 9(2), 145-151.
[http://dx.doi.org/10.1080/10286020412331286506] [PMID: 17454311]
[44]
Wang, H.; Song, H.; Yue, J.; Li, J.; Hou, YB.; Deng, J.L. Rheum officinale (a traditional Chinese medicine) for chronic kidney disease. Cochrane Database Syst. Rev., 2012.
[45]
Yang, J. Clinical use and side effects of Rheum palmatum L. China Practical Medicine., 2012, 7, 131-230.
[46]
Zhong, Y.; Deng, Y.; Chen, Y.; Chuang, P.Y.; Cijiang He, C. J. Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases. Kidney Int., 2013, 84(6), 1108-1118.
[http://dx.doi.org/10.1038/ki.2013.276] [PMID: 23868014]
[47]
Huang, L.; Yao, Y.; Li, J.; Zhang, S.; Li, W.; Dong, N.; Yu, Y.; Sheng, Z. The effect of Astragaloside IV on immune function of regulatory T cell mediated by high mobility group box 1 protein in vitro. Fitoterapia, 2012, 83(8), 1514-1522.
[http://dx.doi.org/10.1016/j.fitote.2012.08.019] [PMID: 22981502]
[48]
Qin, Q.; Niu, J.; Wang, Z.; Xu, W.; Qiao, Z.; Gu, Y. Astragalus membranaceus inhibits inflammation via phospho-P38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB pathways in advanced glycation end product-stimulated macrophages. Int. J. Mol. Sci., 2012, 13(7), 8379-8387.
[http://dx.doi.org/10.3390/ijms13078379] [PMID: 22942709]
[49]
Nalbantsoy, A.; Nesil, T. Yılmaz-Dilsiz, Ö.; Aksu, G.; Khan, S.; Bedir, E. Evaluation of the immunomodulatory properties in mice and in vitro anti-inflammatory activity of cycloartane type saponins from Astragalus species. J. Ethnopharmacol., 2012, 139(2), 574-581.
[http://dx.doi.org/10.1016/j.jep.2011.11.053] [PMID: 22155389]
[50]
Zhao, J.; Yang, P.; Li, F.; Tao, L.; Ding, H.; Rui, Y.; Cao, Z.; Zhang, W. Therapeutic effects of astragaloside IV on myocardial injuries: Multi-target identification and network analysis. PLoS One, 2012, 7(9), e44938.
[http://dx.doi.org/10.1371/journal.pone.0044938]
[51]
Kajiwara, K.; Arai, M.; Nakada, Y.; Kinoue, T. Administration of Astragalus membranaceus prevented kidney dysfunction in older mice following renal ischemia-reperfusion. Int. Med. J., 2019, 26(5), 366-369.
[52]
You, H.; Lu, Y.; Gui, D.; Peng, A.; Chen, J.; Gu, Y. Aqueous extract of Astragali radix ameliorates proteinuria in adriamycin nephropathy rats through inhibition of oxidative stress and endothelial nitric oxide synthase. J. Ethnopharmacol., 2011, 134(1), 176-182.
[http://dx.doi.org/10.1016/j.jep.2010.11.064] [PMID: 21130857]
[53]
Zuo, C.; Xie, X.; Qiu, H.; Deng, Y.; Zhu, D.; Fan, J. Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-β in rats with unilateral ureteral obstruction. J. Zhejiang Univ. Sci. B, 2009, 10(5), 380-390.
[http://dx.doi.org/10.1631/jzus.B0820230] [PMID: 19434765]
[54]
Li, S.; Zhang, Y.; Zhao, J. Preparation and suppressive effect of astragalus polysaccharide in glomerulonephritis rats. Int. Immunopharmacol., 2007, 7(1), 23-28.
[http://dx.doi.org/10.1016/j.intimp.2006.08.016] [PMID: 17161813]
[55]
Zhang, Y.W.; Wu, C.Y.; Cheng, J.T. Merit of Astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mRNA expressions of NF-κB and IκB in renal cortex of streptozotoxin-induced diabetic rats. J. Ethnopharmacol., 2007, 114(3), 387-392.
[http://dx.doi.org/10.1016/j.jep.2007.08.024] [PMID: 17900838]
[56]
Wang, H.; Li, J.; Yu, L.; Zhao, Y.; Ding, W. Antifibrotic effect of the Chinese herbs, Astragalus mongholicus and Angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis. Life Sci., 2004, 74(13), 1645-1658.
[http://dx.doi.org/10.1016/j.lfs.2003.08.036] [PMID: 14738908]
[57]
Meng, L.; Van Putten, V.; Qu, L.; Nemenoff, R.; Shang, M.Y.; Cai, S.Q.; Li, X. Altered expression of genes profiles modulated by a combination of Astragali radix and Angelicae sinensis Radix in obstructed rat kidney. Planta Med., 2010, 76(13), 1431-1438.
[http://dx.doi.org/10.1055/s-0029-1240943] [PMID: 20195958]
[58]
Li, M.; Wang, W.; Xue, J.; Gu, Y.; Lin, S. Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. J. Ethnopharmacol., 2011, 133(2), 412-419.
[http://dx.doi.org/10.1016/j.jep.2010.10.012] [PMID: 20951192]
[59]
Zhang, J.; Xie, X.; Li, C.; Fu, P. Systematic review of the renal protective effect of Astragalus membranaceus (root) on diabetic nephropathy in animal models. J. Ethnopharmacol., 2009, 126(2), 189-196.
[http://dx.doi.org/10.1016/j.jep.2009.08.046] [PMID: 19735713]
[60]
Ahmed, M.S.; Hou, S.H.; Battaglia, M.C.; Picken, M.M.; Leehey, D.J. Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus. Am. J. Kidney Dis., 2007, 50(6), 1028-1032.
[http://dx.doi.org/10.1053/j.ajkd.2007.07.032] [PMID: 18037104]
[61]
Pao, L.H.; Hu, O.Y.P.; Fan, H.Y.; Lin, C.C.; Liu, L.C.; Huang, P.W. Herb-drug interaction of 50 Chinese herbal medicines on CYP3A4 activity in vitro and in vivo. Am. J. Chin. Med., 2012, 40(1), 57-73.
[http://dx.doi.org/10.1142/S0192415X1250005X] [PMID: 22298448]
[62]
Chen, S.; Li, Z.; Krochmal, R.; Abrazado, M.; Kim, W.; Cooper, C.B. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: A double-blind, placebo-controlled trial. J. Altern. Complement. Med., 2010, 16(5), 585-590.
[http://dx.doi.org/10.1089/acm.2009.0226] [PMID: 20804368]
[63]
Paterson, R.R.M. Cordyceps – A traditional Chinese medicine and another fungal therapeutic biofactory? Phytochemistry, 2008, 69(7), 1469-1495.
[http://dx.doi.org/10.1016/j.phytochem.2008.01.027] [PMID: 18343466]
[64]
Ng, T.B.; Wang, H.X. Pharmacological actions of Cordyceps, a prized folk medicine. J. Pharm. Pharmacol., 2010, 57(12), 1509-1519.
[http://dx.doi.org/10.1211/jpp.57.12.0001] [PMID: 16354395]
[65]
Yang, L.Y.; Huang, W.J.; Hsieh, H.G.; Lin, C.Y. H1-A extracted from Cordyceps sinensis suppresses the proliferation of human mesangial cells and promotes apoptosis, probably by inhibiting the tyrosine phosphorylation of Bcl-2 and Bcl-XL. J. Lab. Clin. Med., 2003, 141(1), 74-83.
[http://dx.doi.org/10.1067/mlc.2003.6] [PMID: 12518171]
[66]
Li, S.P.; Zhao, K.J.; Ji, Z.N.; Song, Z.H.; Dong, T.T.X.; Lo, C.K.; Cheung, J.K.H.; Zhu, S.Q.; Tsim, K.W.K. A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury. Life Sci., 2003, 73(19), 2503-2513.
[http://dx.doi.org/10.1016/S0024-3205(03)00652-0] [PMID: 12954458]
[67]
Shahed, AR.; Kim, SI.; Shoskes, DA. Down-regulation of apoptotic and inflammatory genes by Cordyceps sinensis extract in rat kidney following ischemia/reperfusion. Transpl. Proceed, 2001, 33(6), 2986-2987.
[68]
Yang, L.Y.; Chen, A.; Kuo, Y.C.; Lin, C.Y. Efficacy of a pure compound H1-A extracted from Cordyceps sinensis on autoimmune disease of MRL lpr/lpr mice. J. Lab. Clin. Med., 1999, 134(5), 492-500.
[http://dx.doi.org/10.1016/S0022-2143(99)90171-3] [PMID: 10560943]
[69]
Xu, F.; Huang, J.B.; Jiang, L.; Xu, J.; Mi, J. Amelioration of cyclosporin nephrotoxicity by Cordyceps sinensis in kidney-transplanted recipients. Nephrol. Dial. Transplant., 1995, 10(1), 142-143.
[PMID: 7724020]
[70]
Li, Y.; Fan, P.; Ding, X.M.; Tian, X.H.; Feng, X.S.; Yan, H.; Pan, X.M.; Tian, P.X.; Zheng, J.; Ding, C.G.; Xue, W.J. Polyglycolic acid fibrous scaffold improving endothelial cell coating and vascularization of islet. Chin. Med. J., 2017, 130(7), 832-839.
[http://dx.doi.org/10.4103/0366-6999.202730] [PMID: 28345548]
[71]
Zhang, Z.; Wang, X.; Zhang, Y.; Ye, G. Effect of Cordyceps sinensis on renal function of patients with chronic allograft nephropathy. Urol. Int., 2011, 86(3), 298-301.
[http://dx.doi.org/10.1159/000323655] [PMID: 21335937]
[72]
Shao, G. Treatment of hyperlipidemia with cultivated Cordyceps - A double-blind, randomized placebo control trial. Chin J. Mod. Develop. Traditional Med., 1985, 5(11), 652-654.
[73]
Xu, R.H.; Peng, X.E.; Chen, G.Z.; Chen, G.L. Effects of Cordyceps sinensis on natural killer activity and colony formation of B16 melanoma. Chin. Med. J., 1992, 105(2), 97-101.
[PMID: 1597083]
[74]
Zhou, Z.L.; Yang, Y.X.; Ding, J.; Li, Y.C.; Miao, Z.H. Triptolide: Structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms. Nat. Prod. Rep., 2012, 29(4), 457-475.
[http://dx.doi.org/10.1039/c2np00088a] [PMID: 22270059]
[75]
Liu, Q. Triptolide and its expanding multiple pharmacological functions. Int. Immunopharmacol., 2011, 11(3), 377-383.
[http://dx.doi.org/10.1016/j.intimp.2011.01.012] [PMID: 21255694]
[76]
Han, R.; Rostami-Yazdi, M.; Gerdes, S.; Mrowietz, U. Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases. Br. J. Clin. Pharmacol., 2012, 74(3), 424-436.
[http://dx.doi.org/10.1111/j.1365-2125.2012.04221.x] [PMID: 22348323]
[77]
Qiu, D.; Kao, P.N. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D., 2003, 4(1), 1-18.
[http://dx.doi.org/10.2165/00126839-200304010-00001] [PMID: 12568630]
[78]
Zheng, C.X.; Chen, Z.H.; Zeng, C.H.; Qin, W.S.; Li, L.S.; Liu, Z.H. Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro. Kidney Int., 2008, 74(5), 596-612.
[http://dx.doi.org/10.1038/ki.2008.203] [PMID: 18509322]
[79]
Chen, Z.H.; Qin, W.S.; Zeng, C.H.; Zheng, C.X.; Hong, Y.M.; Lu, Y.Z.; Li, L.S.; Liu, Z.H. Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro. Kidney Int., 2010, 77(11), 974-988.
[http://dx.doi.org/10.1038/ki.2010.41] [PMID: 20375980]
[80]
Leuenroth, S.J.; Bencivenga, N.; Igarashi, P.; Somlo, S.; Crews, C.M. Triptolide reduces cystogenesis in a model of ADPKD. J. Am. Soc. Nephrol., 2008, 19(9), 1659-1662.
[http://dx.doi.org/10.1681/ASN.2008030259] [PMID: 18650476]
[81]
Liu, J.; Jiang, Z.; Liu, L.; Zhang, Y.; Zhang, S.; Xiao, J.; Ma, M.; Zhang, L. Triptolide induces adverse effect on reproductive parameters of female Sprague-Dawley rats. Drug Chem. Toxicol., 2011, 34(1), 1-7.
[http://dx.doi.org/10.3109/01480541003774358] [PMID: 20954797]
[82]
Yang, Y.; Liu, Z.; Tolosa, E.; Yang, J.; Li, L. Triptolide induces apoptotic death of T lymphocyte. Immunopharmacology, 1998, 40(2), 139-149.
[http://dx.doi.org/10.1016/S0162-3109(98)00036-8] [PMID: 9826028]
[83]
Li, J.; Jin, J.; Li, M.; Guan, C.; Wang, W.; Zhu, S.; Qiu, Y.; Huang, M.; Huang, Z. Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells. Toxicol. Lett., 2012, 213(2), 194-202.
[http://dx.doi.org/10.1016/j.toxlet.2012.07.008] [PMID: 22820427]
[84]
Bomback, A.S.; Kshirsagar, A.V.; Amamoo, M.A.; Klemmer, P.J. Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: A systematic review. Am. J. Kidney Dis., 2008, 51(2), 199-211.
[http://dx.doi.org/10.1053/j.ajkd.2007.10.040] [PMID: 18215698]
[85]
Wu, M.F.; Li, P.C.; Chen, C.C.; Ye, S.S.; Chien, C.T.; Yu, C.C. Cordyceps sobolifera extract ameliorates lipopolysaccharide-induced renal dysfunction in the rat. Am. J. Chin. Med., 2011, 39(3), 523-535.
[http://dx.doi.org/10.1142/S0192415X11009007] [PMID: 21598419]
[86]
Ashour, M.L.; Wink, M. Genus Bupleurum: A review of its phytochemistry, pharmacology and modes of action. J. Pharm. Pharmacol., 2011, 63(3), 305-321.
[http://dx.doi.org/10.1111/j.2042-7158.2010.01170.x] [PMID: 21749378]
[87]
Kishida, Y.; Nishii, T.; Sugano, N.; Nakanishi, K.; Sakai, T.; Miki, H.; Ochi, T.; Yoshikawa, H. Measurement of lesion area and volume by three-dimensional spoiled gradient-echo MR imaging in osteonecrosis of the femoral head. J. Orthop. Res., 2003, 21(5), 850-858.
[http://dx.doi.org/10.1016/S0736-0266(03)00043-3] [PMID: 12919873]
[88]
Awazu, M.; Fujita, H.; Omori, S.; Hida, M. The herbal medicine Sairei-to inhibits proliferation of rat mesangial cells. Nephron J., 2002, 92(3), 652-659.
[http://dx.doi.org/10.1159/000064112] [PMID: 12372950]
[89]
Lu, C.N.; Yuan, Z.G.; Zhang, X.L.; Yan, R.; Zhao, Y.Q.; Liao, M.; Chen, J.X. Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway. Int. Immunopharmacol., 2012, 14(1), 121-126.
[http://dx.doi.org/10.1016/j.intimp.2012.06.010] [PMID: 22728095]
[90]
Zu, N.; Li, P.; Li, N.; Choy, P.; Gong, Y. Mechanism of saikosaponin-d in the regulation of rat mesangial cell proliferation and synthesis of extracellular matrix proteins. Biochem. Cell Biol., 2007, 85(2), 169-174.
[http://dx.doi.org/10.1139/O07-002] [PMID: 17534396]
[91]
Wong, V.K.W.; Zhou, H.; Cheung, S.S.F.; Li, T.; Liu, L. Mechanistic study of saikosaponin-d (Ssd) on suppression of murine T lymphocyte activation. J. Cell. Biochem., 2009, 107(2), 303-315.
[http://dx.doi.org/10.1002/jcb.22126] [PMID: 19301261]
[92]
Ono, T.; Liu, N.; Makino, T.; Nogaki, F.; Muso, E.; Honda, G.; Kita, T. Suppressive mechanisms of Sairei-to on mesangial matrix expansion in rat mesangioproliferative glomerulonephritis. Nephron, Exp. Nephrol., 2005, 100(3), e132-e142.
[http://dx.doi.org/10.1159/000085059] [PMID: 15824516]
[93]
Kimura, K.; Ogawa, S.; Tojo, A.; Nanba, S. Effects of a Japanese medicinal plant on the rat subtotal nephrectomy model: Evaluation of its effect by microvascular casts. Am. J. Chin. Med., 1990, 18(3-4), 167-174.
[http://dx.doi.org/10.1142/S0192415X90000216]
[94]
Kawachi, H.; Takashima, N.; Orikasa, M.; Oite, T.; Shimizu, F. Effect of traditional Chinese medicine (Sairei-to) on monoclonal antibody-induced proteinuria in rats. Pathol. Int., 1994, 44(5), 339-344.
[http://dx.doi.org/10.1111/j.1440-1827.1994.tb02933.x] [PMID: 8044302]
[95]
Satoh, S.; Kaneko, T.; Omori, S.; Sugimura, J.; Ujiie, T.; Fujioka, T.; Kubo, T. The effect of enalapril and sairei-to on survival-time for the rat with subtotal nephrectomy. Nippon Jinzo Gakkai Shi, 1995, 37(2), 112-118.
[PMID: 7752502]
[96]
Ohno, I.; Shibasaki, T.; Nakano, H.; Matsuda, H.; Matsumoto, H.; Misawa, T.; Ishimoto, F.; Sakai, O. Effect of Sairei-to on gentamicin nephrotoxicity in rats. Arch. Toxicol., 1993, 67(2), 145-147.
[http://dx.doi.org/10.1007/BF01973686] [PMID: 8481103]
[97]
Yoshioka, K.; Ohashi, Y.; Sakai, T.; Ito, H.; Yoshikawa, N.; Nakamura, H.; Tanizawa, T.; Wada, H.; Maki, S. A multicenter trial of mizoribine compared with placebo in children with frequently relapsing nephrotic syndrome. Kidney Int., 2000, 58(1), 317-324.
[http://dx.doi.org/10.1046/j.1523-1755.2000.00168.x] [PMID: 10886577]
[98]
Lu, P.; Wang, Z.H. Discussion on Xiao Chai Hu Tang clinical application and its side effects. Chinese Primary Health Care., 2008, 22, 80-82.
[99]
Asano, T.; Fujii, Y.; Numao, N.; Kageyama, Y.; Kihara, K. The efficiency of Sairei-to for retroperitoneal fibrosis: Two case reports. Hinyokika Kiyo, 2006, 52(7), 543-547.
[PMID: 16910587]
[100]
Miyagawa, T.; Mochizuki, Y.; Nakahara, Y.; Kawamura, T.; Sasaki, S.; Tsukamoto, H.; Tabata, H.; Okada, H. A case of drug-induced pneumonitis due to Sai-rei-to. Nihon Kokyuki Gakkai Zasshi, 2009, 47(1), 47-51.
[101]
Aiba, T.; Takahashi, T.; Suzuki, K.; Okoshi, S.; Nomoto, M.; Uno, K.; Aoyagi, Y. Liver injury induced by a Japanese herbal medicine, sairei-to (TJ-114, Bupleurum and Hoelen Combination, Chai-Ling-Tang) R1. J. Gastroenterol. Hepatol., 2007, 22(5), 762-763.
[http://dx.doi.org/10.1111/j.1440-1746.2006.03373.x] [PMID: 17444872]

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