Generic placeholder image

Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Research Article

Diterpenoid Tanshinone Attenuates the Metastasis of Non-small-cell Lung Cancer (NSCLC) Cells by Inhibiting the Cavin-1-mediated ERK/Smad2 Signaling Pathway

Author(s): Lu Wang, Gangdan Jiang and Xiaojuan Li*

Volume 23, Issue 14, 2023

Published on: 01 June, 2023

Page: [1618 - 1625] Pages: 8

DOI: 10.2174/1871520623666230417090504

Price: $65

Abstract

Background: Non-small cell lung cancer (NSCLC) is a common malignant cancer with high incidence and mortality. In recent decade, despite the progress in the treatment and prevention of NSCLC, its prognosis still remains poor. It is urgently needed to identify new potential mechanism and efficacious drugs for NSCLC patients.

Objective: The objective of this study is to explore the potential therapeutic role of diterpenoid tanshinone (DT) against non-small cell lung cancer (NSCLC) in vitro and elucidate the molecular mechanism involved in tumor metastasis.

Methods: Human NSCLC lines (A549 and NCI-H1299) were transfected with pcDNA3.1-Cavin-1 plasmids and corresponding controls. We tested the effects of DT on migration and invasion of lung cancer cells using transwell filters coated with fibronectin and Matrigel. Next, Quantitative Real-Time PCR and western blot were used to determine the transcriptional and protein levels of epithelial-mesenchymal transition (EMT) markers, transcription factors (Snail, Slug), and matrix metalloproteinases.

Results: As expected, Cavin-1 related to the enhanced ability of cell migration and invasion. DT not only inhibited the migratory and invasive capacity of Cavin-1-transfected NSCLC cells but also significantly increased the expression of ZEB1 and E-cadherin and decreased the level of N-cadherin, Vimentin, Snail, and Slug. Moreover, DT treatment obviously alleviated Cavin-1 overexpression-induced high levels of MMP2, MMP7, and MMP9 at both the protein and transcriptional levels. Furthermore, overexpressed Cavin-1 upregulated ERK and Smad2 signaling pathways in NSCLC cells, which were also strongly weakened by DT administration.

Conclusion: Our results suggested that DT effectively attenuates Cavin-1-mediated NSCLC metastasis via the ERK/Smad2 signaling pathway.

Graphical Abstract

[1]
Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 2021, 71(3), 209-249.
[http://dx.doi.org/10.3322/caac.21660] [PMID: 33538338]
[2]
Siegel, R.L.; Miller, K.D.; Fuchs, H.E.; Jemal, A. Cancer Statistics, 2021. CA Cancer J. Clin., 2021, 71(1), 7-33.
[http://dx.doi.org/10.3322/caac.21654] [PMID: 33433946]
[3]
Zheng, R.S.; Sun, K.X.; Zhang, S.W.; Zeng, H.M.; Zou, X.N.; Chen, R.; Gu, X.Y.; Wei, W.W.; He, J. Report of cancer epidemiology in China, 2015. Zhonghua Zhong Liu Za Zhi, 2019, 41(1), 19-28.
[PMID: 30678413]
[4]
Allemani, C.; Matsuda, T.; Di Carlo, V.; Harewood, R.; Matz, M. Nikšić M.; Bonaventure, A.; Valkov, M.; Johnson, C.J.; Estève, J.; Ogunbiyi, O.J.; Azevedo e Silva, G.; Chen, W.Q.; Eser, S.; Engholm, G.; Stiller, C.A.; Monnereau, A.; Woods, R.R.; Visser, O.; Lim, G.H.; Aitken, J.; Weir, H.K.; Coleman, M.P.; Bouzbid, S.; Hamdi-Chérif, M.; Zaidi, Z.; Meguenni, K.; Regagba, D.; Bayo, S.; Bougadari, C.T.; Manraj, S.S.; Bendahhou, K.; Fabowale, A.; Bradshaw, D.; Somdyala, N.I.M.; Kumcher, I.; Moreno, F.; Calabrano, G.H.; Espinola, S.B.; Quintero, C.B.; Fita, R.; Diumenjo, M.C.; Laspada, W.D.; Ibañez, S.G.; Lima, C.A.; De Souza, P.C.F.; Del Pino, K.; Laporte, C.; Curado, M.P.; de Oliveira, J.C.; Veneziano, C.L.A.; Veneziano, D.B.; Latorre, M.R.D.O.; Tanaka, L.F.; Rebelo, M.S.; Santos, M.O.; Galaz, J.C.; Aravena, A.M.; Monsalve, S.J.; Herrmann, D.A.; Vargas, S.; Herrera, V.M.; Uribe, C.J.; Bravo, L.E.; Garcia, L.S.; Arias-Ortiz, N.E.; Morantes, D.; Jurado, D.M.; Yépez Chamorro, M.C.; Delgado, S.; Ramirez, M.; Alvarez, G.Y.H.; Torres, P.; Martínez-Reyes, F.; Jaramillo, L.; Quinto, R.; Castillo, J.; Mendoza, M.; Cueva, P.; Yépez, J.G.; Bhakkan, B.; Deloumeaux, J.; Joachim, C.; Macni, J.; Carrillo, R.; Klincovstein, S.J.; Gomez, R.R.; Poquioma, E.; Tortolero-Luna, G.; Zavala, D.; Alonso, R.; Barrios, E.; Eckstrand, A.; Nikiforuk, C.; Noonan, G.; Turner, D.; Kumar, E.; Zhang, B.; McCrate, F.R.; Ryan, S.; MacIntyre, M.; Saint-Jacques, N.; Nishri, D.E.; McClure, C.A.; Vriends, K.A.; Kozie, S.; Stuart-Panko, H.; Freeman, T.; George, J.T.; Brockhouse, J.T.; O’Brien, D.K.; Holt, A.; Almon, L.; Kwong, S.; Morris, C.; Rycroft, R.; Mueller, L.; Phillips, C.E.; Brown, H.; Cromartie, B.; Schwartz, A.G.; Vigneau, F.; Levin, G.M.; Wohler, B.; Bayakly, R.; Ward, K.C.; Gomez, S.L.; McKinley, M.; Cress, R.; Green, M.D.; Miyagi, K.; Ruppert, L.P.; Lynch, C.F.; Huang, B.; Tucker, T.C.; Deapen, D.; Liu, L.; Hsieh, M.C.; Wu, X.C.; Schwenn, M.; Gershman, S.T.; Knowlton, R.C.; Alverson, G.; Copeland, G.E.; Bushhouse, S.; Rogers, D.B.; Jackson-Thompson, J.; Lemons, D.; Zimmerman, H.J.; Hood, M.; Roberts-Johnson, J.; Rees, J.R.; Riddle, B.; Pawlish, K.S.; Stroup, A.; Key, C.; Wiggins, C.; Kahn, A.R.; Schymura, M.J.; Radhakrishnan, S.; Rao, C.; Giljahn, L.K.; Slocumb, R.M.; Espinoza, R.E.; Khan, F.; Aird, K.G.; Beran, T.; Rubertone, J.J.; Slack, S.J.; Garcia, L.; Rousseau, D.L.; Janes, T.A.; Schwartz, S.M.; Bolick, S.W.; Hurley, D.M.; Whiteside, M.A.; Miller-Gianturco, P.; Williams, M.A.; Herget, K.; Sweeney, C.; Johnson, A.T.; Cheteri, K.M.B.; Santiago, M.P.; Blankenship, S.E.; Farley, S.; Borchers, R.; Malicki, R.; Espinoza, J.R.; Grandpre, J.; Wilson, R.; Edwards, B.K.; Mariotto, A.; Lei, Y.; Wang, N.; Chen, J.S.; Zhou, Y.; He, Y.T.; Song, G.H.; Gu, X.P.; Mei, D.; Mu, H.J.; Ge, H.M.; Wu, T.H.; Li, Y.Y.; Zhao, D.L.; Jin, F.; Zhang, J.H.; Zhu, F.D.; Junhua, Q.; Yang, Y.L.; Jiang, C.X.; Biao, W.; Wang, J.; Li, Q.L.; Yi, H.; Zhou, X.; Dong, J.; Li, W.; Fu, F.X.; Liu, S.Z.; Chen, J.G.; Zhu, J.; Li, Y.H.; Lu, Y.Q.; Fan, M.; Huang, S.Q.; Guo, G.P.; Zhaolai, H.; Wei, K.; Zeng, H.; Demetriou, A.V.; Mang, W.K.; Ngan, K.C.; Kataki, A.C.; Krishnatreya, M.; Jayalekshmi, P.A.; Sebastian, P.; Nandakumar, A.; Malekzadeh, R.; Roshandel, G.; Keinan-Boker, L.; Silverman, B.G.; Ito, H.; Nakagawa, H.; Sato, M.; Tobori, F.; Nakata, I.; Teramoto, N.; Hattori, M.; Kaizaki, Y.; Moki, F.; Sugiyama, H.; Utada, M.; Nishimura, M.; Yoshida, K.; Kurosawa, K.; Nemoto, Y.; Narimatsu, H.; Sakaguchi, M.; Kanemura, S.; Naito, M.; Narisawa, R.; Miyashiro, I.; Nakata, K.; Sato, S.; Yoshii, M.; Oki, I.; Fukushima, N.; Shibata, A.; Iwasa, K.; Ono, C.; Nimri, O.; Jung, K.W.; Won, Y.J.; Alawadhi, E.; Elbasmi, A.; Ab Manan, A.; Adam, F.; Sanjaajmats, E.; Tudev, U.; Ochir, C.; Al Khater, A.M.; El Mistiri, M.M.; Teo, Y.Y.; Chiang, C.J.; Lee, W.C.; Buasom, R.; Sangrajrang, S.; Kamsa-ard, S.; Wiangnon, S.; Daoprasert, K.; Pongnikorn, D.; Leklob, A.; Sangkitipaiboon, S.; Geater, S.L.; Sriplung, H.; Ceylan, O.; Kög, I.; Dirican, O.; Köse, T.; Gurbuz, T.; Karaşahin, F.E.; Turhan, D.; Aktaş U.; Halat, Y.; Yakut, C.I.; Altinisik, M.; Cavusoglu, Y.; Türkköylü, A.; Üçüncü, N.; Hackl, M.; Zborovskaya, A.A.; Aleinikova, O.V.; Henau, K.; Van Eycken, L.; Valerianova, Z.; Yordanova, M.R.; Šekerija, M.; Dušek, L.; Zvolský, M.; Storm, H.; Innos, K.; Mägi, M.; Malila, N.; Seppä, K.; Jégu, J.; Velten, M.; Cornet, E.; Troussard, X.; Bouvier, A.M.; Guizard, A.V.; Bouvier, V.; Launoy, G.; Arveux, P.; Maynadié, M.; Mounier, M.; Woronoff, A.S.; Daoulas, M.; Robaszkiewicz, M.; Clavel, J.; Goujon, S.; Lacour, B.; Baldi, I.; Pouchieu, C.; Amadeo, B.; Coureau, G.; Orazio, S.; Preux, P.M.; Rharbaoui, F.; Marrer, E.; Trétarre, B.; Colonna, M.; Delafosse, P.; Ligier, K.; Plouvier, S.; Cowppli-Bony, A.; Molinié, F.; Bara, S.; Ganry, O.; Lapôtre-Ledoux, B.; Grosclaude, P.; Bossard, N.; Uhry, Z.; Bray, F.; Piñeros, M.; Stabenow, R.; Wilsdorf-Köhler, H.; Eberle, A.; Luttmann, S.; Löhden, I.; Nennecke, A.L.; Kieschke, J.; Sirri, E.; Emrich, K.; Zeissig, S.R.; Holleczek, B.; Eisemann, N.; Katalinic, A.; Asquez, R.A.; Kumar, V.; Petridou, E.; Ólafsdóttir, E.J.; Tryggvadóttir, L.; Clough-Gorr, K.; Walsh, P.M.; Sundseth, H.; Mazzoleni, G.; Vittadello, F.; Coviello, E.; Cuccaro, F.; Galasso, R.; Sampietro, G.; Giacomin, A.; Magoni, M.; Ardizzone, A.; D’Argenzio, A.; Castaing, M.; Grosso, G.; Lavecchia, A.M.; Sutera Sardo, A.; Gola, G.; Gatti, L.; Ricci, P.; Ferretti, S.; Serraino, D.; Zucchetto, A.; Celesia, M.V.; Filiberti, R.A.; Pannozzo, F.; Melcarne, A.; Quarta, F.; Russo, A.G.; Carrozzi, G.; Cirilli, C.; Cavalieri d’Oro, L.; Rognoni, M.; Fusco, M.; Vitale, M.F.; Usala, M.; Cusimano, R.; Mazzucco, W.; Michiara, M.; Sgargi, P.; Boschetti, L.; Borciani, E.; Seghini, P.; Maule, M.M.; Merletti, F.; Tumino, R.; Mancuso, P.; Vicentini, M.; Cassetti, T.; Sassatelli, R.; Falcini, F.; Giorgetti, S.; Caiazzo, A.L.; Cavallo, R.; Cesaraccio, R.; Pirino, D.R.; Contrino, M.L.; Tisano, F.; Fanetti, A.C.; Maspero, S.; Carone, S.; Mincuzzi, A.; Candela, G.; Scuderi, T.; Gentilini, M.A.; Piffer, S.; Rosso, S.; Barchielli, A.; Caldarella, A.; Bianconi, F.; Stracci, F.; Contiero, P.; Tagliabue, G.; Rugge, M.; Zorzi, M.; Beggiato, S.; Brustolin, A.; Berrino, F.; Gatta, G.; Sant, M.; Buzzoni, C.; Mangone, L.; Capocaccia, R.; De Angelis, R.; Zanetti, R.; Maurina, A.; Pildava, S.; Lipunova, N.; Vincerževskiené, I.; Agius, D.; Calleja, N.; Siesling, S.; Larønningen, S.; Møller, B.; Dyzmann-Sroka, A.; Trojanowski, M.; Góźdź, S.; Mężyk, R.; Mierzwa, T.; Molong, L.; Rachtan, J.; Szewczyk, S.; Błaszczyk, J.; Kępska, K.; Kościańska, B.; Tarocińska, K.; Zwierko, M.; Drosik, K.; Maksimowicz, K.M.; Purwin-Porowska, E.; Reca, E.; Wójcik-Tomaszewska, J.; Tukiendorf, A.; Grądalska-Lampart, M.; Radziszewska, A.U.; Gos, A.; Talerczyk, M.; Wyborska, M.; Didkowska, J.A.; Wojciechowska, U.; Bielska-Lasota, M.; Forjaz de Lacerda, G.; Rego, R.A.; Bastos, J.; Silva, M.A.; Antunes, L.; Laranja Pontes, J.; Mayer-da-Silva, A.; Miranda, A.; Blaga, L.M.; Coza, D.; Gusenkova, L.; Lazarevich, O.; Prudnikova, O.; Vjushkov, D.M.; Egorova, A.G.; Orlov, A.E.; Kudyakov, L.A.; Pikalova, L.V.; Adamcik, J.; Safaei Diba, C.; Primic-Žakelj, M.; Zadnik, V.; Larrañaga, N.; Lopez de Munain, A.; Herrera, A.A.; Redondas, R.; Marcos-Gragera, R.; Vilardell Gil, M.L.; Molina, E.; Perez, S.M.J.; Sureda, F.P.; Montserrat, R.M.; Chirlaque, M.D.; Navarro, C.; Ardanaz, E.E.; Guevara, M.M.; Fernández-Delgado, R.; Peris-Bonet, R.; Carulla, M.; Galceran, J.; Alberich, C.; Vicente-Raneda, M.; Khan, S.; Pettersson, D.; Dickman, P.; Avelina, I.; Staehelin, K.; Camey, B.; Bouchardy, C.; Schaffar, R.; Frick, H.; Herrmann, C.; Bulliard, J.L.; Maspoli-Conconi, M.; Kuehni, C.E.; Redmond, S.M.; Bordoni, A.; Ortelli, L.; Chiolero, A.; Konzelmann, I.; Matthes, K.L.; Rohrmann, S.; Broggio, J.; Rashbass, J.; Fitzpatrick, D.; Gavin, A.; Clark, D.I.; Deas, A.J.; Huws, D.W.; White, C.; Montel, L.; Rachet, B.; Turculet, A.D.; Stephens, R.; Chalker, E.; Phung, H.; Walton, R.; You, H.; Guthridge, S.; Johnson, F.; Gordon, P.; D’Onise, K.; Priest, K.; Stokes, B.C.; Venn, A.; Farrugia, H.; Thursfield, V.; Dowling, J.; Currow, D.; Hendrix, J.; Lewis, C. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet, 2018, 391(10125), 1023-1075.
[http://dx.doi.org/10.1016/S0140-6736(17)33326-3] [PMID: 29395269]
[5]
Xu, J.; Wei, K.; Zhang, G.; Lei, L.; Yang, D.; Wang, W.; Han, Q.; Xia, Y.; Bi, Y.; Yang, M.; Li, M. Ethnopharmacology, phytochemistry, and pharmacology of Chinese Salvia species: A review. J. Ethnopharmacol., 2018, 225, 18-30.
[http://dx.doi.org/10.1016/j.jep.2018.06.029] [PMID: 29935346]
[6]
Estolano-Cobián, A.; Alonso, M.M.; Díaz-Rubio, L.; Ponce, C.N.; Córdova-Guerrero, I.; Marrero, J.G. Tanshinones and their derivatives: Heterocyclic ring-fused diterpenes of biological interest. Mini Rev. Med. Chem., 2021, 21(2), 171-185.
[http://dx.doi.org/10.2174/1389557520666200429103225] [PMID: 32348220]
[7]
Li, Z.; Zou, J.; Cao, D.; Ma, X. Pharmacological basis of tanshinone and new insights into tanshinone as a multitarget natural product for multifaceted diseases. Biomed. Pharmacother., 2020, 130, 110599.
[http://dx.doi.org/10.1016/j.biopha.2020.110599] [PMID: 33236719]
[8]
Li, N.; Yang, L.; Zhang, B.; Chen, S. Tanshinone IIA effects on ovarian cancer cell line. J. Pharm. Pharmacol., 2018, 70(10), 1369-1377.
[http://dx.doi.org/10.1111/jphp.12961] [PMID: 29943422]
[9]
Li, S.; Zhaohuan, L.; Guangshun, Z.; Guanhua, X.; Guangji, Z. Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines. J. Tradit. Chin. Med., 2016, 36(4), 514-521.
[http://dx.doi.org/10.1016/S0254-6272(16)30069-3] [PMID: 28459519]
[10]
Lou, Z.H.; Xia, R.M.; Li, X.J.; Cheng, R.B.; Shao, K.D.; Zhang, G.J. Anti-lung cancer mechanisms of diterpenoid tanshinone via endoplasmic reticulum stress-mediated apoptosis signal pathway. Zhongguo Zhongyao Zazhi, 2018, 43(24), 4900-4907.
[PMID: 30717537]
[11]
Chettimada, S.; Yang, J.; Moon, H.G.; Jin, Y. Caveolae, caveolin-1 and cavin-1: Emerging roles in pulmonary hypertension. World J. Respirol., 2015, 5(2), 126-134.
[http://dx.doi.org/10.5320/wjr.v5.i2.126] [PMID: 28529892]
[12]
Hill, M.M.; Bastiani, M.; Luetterforst, R.; Kirkham, M.; Kirkham, A.; Nixon, S.J.; Walser, P.; Abankwa, D.; Oorschot, V.M.J.; Martin, S.; Hancock, J.F.; Parton, R.G. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell, 2008, 132(1), 113-124.
[http://dx.doi.org/10.1016/j.cell.2007.11.042] [PMID: 18191225]
[13]
Liu, L.; Xu, H-X.; Wang, W-Q.; Wu, C-T.; Chen, T.; Qin, Y.; Liu, C.; Xu, J.; Long, J.; Zhang, B.; Xu, Y-F.; Ni, Q-X.; Li, M.; Yu, X-J. Cavin-1 is essential for the tumor-promoting effect of caveolin-1 and enhances its prognostic potency in pancreatic cancer. Oncogene, 2014, 33(21), 2728-2736.
[http://dx.doi.org/10.1038/onc.2013.223] [PMID: 23770857]
[14]
Tulchinsky, E.; Demidov, O.; Kriajevska, M.; Barlev, N.A.; Imyanitov, E. EMT: A mechanism for escape from EGFR-targeted therapy in lung cancer. Biochim. Biophys. Acta Rev. Cancer, 2019, 1871(1), 29-39.
[http://dx.doi.org/10.1016/j.bbcan.2018.10.003] [PMID: 30419315]
[15]
Zhu, X.; Chen, L.; Liu, L.; Niu, X. EMT-mediated acquired EGFR-TKI resistance in NSCLC: Mechanisms and strategies. Front. Oncol., 2019, 9, 1044.
[http://dx.doi.org/10.3389/fonc.2019.01044] [PMID: 31681582]
[16]
Götte, M.; Kovalszky, I. Extracellular matrix functions in lung cancer. Matrix Biol., 2018, 73, 105-121.
[http://dx.doi.org/10.1016/j.matbio.2018.02.018] [PMID: 29499357]
[17]
Lin, L.; Cheng, K.; He, Z.; Lin, Q.; Huang, Y.; Chen, C.; Xie, Z.; Chen, L.; Liang, Z. A polysaccharide from Hedyotis diffusa interrupts metastatic potential of lung adenocarcinoma A549 cells by inhibiting EMT via EGFR/Akt/ERK signaling pathways. Int. J. Biol. Macromol., 2019, 129, 706-714.
[http://dx.doi.org/10.1016/j.ijbiomac.2019.02.040] [PMID: 30738900]
[18]
Wu, N.; Jiang, M.; Liu, H.; Chu, Y.; Wang, D.; Cao, J.; Wang, Z.; Xie, X.; Han, Y.; Xu, B. LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway. Cell Death Differ., 2021, 28(1), 219-232.
[http://dx.doi.org/10.1038/s41418-020-0596-y] [PMID: 32737443]
[19]
Livak, K.J.; Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Method. Methods, 2001, 25(4), 402-408.
[http://dx.doi.org/10.1006/meth.2001.1262] [PMID: 11846609]
[20]
Tao, X.; Ning, Y.; Zhao, X.; Pan, T. The effects of cordycepin on the cell proliferation, migration and apoptosis in human lung cancer cell lines A549 and NCI-H460. J. Pharm. Pharmacol., 2016, 68(7), 901-911.
[http://dx.doi.org/10.1111/jphp.12544] [PMID: 27138740]
[21]
Gupta, R.; Toufaily, C.; Annabi, B. Caveolin and cavin family members: Dual roles in cancer. Biochimie, 2014, 107(Pt B), Pt B.
[http://dx.doi.org/10.1016/j.biochi.2014.09.010] [PMID: 25241255]
[22]
Low, J.Y.; Brennen, W.N.; Meeker, A.K.; Ikonen, E.; Simons, B.W.; Laiho, M. Stromal CAVIN1 controls prostate cancer microenvironment and metastasis by modulating lipid distribution and inflammatory signaling. Mol. Cancer Res., 2020, 18(9), 1414-1426.
[http://dx.doi.org/10.1158/1541-7786.MCR-20-0364] [PMID: 32493699]
[23]
Lin, S.; Zhang, X.; Huang, G.; Cheng, L.; Lv, J.; Zheng, D.; Lin, S.; Wang, S.; Wu, Q.; Long, Y.; Li, B.; Wei, W.; Liu, P.; Pei, D.; Li, Y.; Wen, Z.; Cui, S.; Li, P.; Sun, X.; Wu, Y.; Yao, Y. Myeloid-derived suppressor cells promote lung cancer metastasis by CCL11 to activate ERK and AKT signaling and induce epithelial-mesenchymal transition in tumor cells. Oncogene, 2021, 40(8), 1476-1489.
[http://dx.doi.org/10.1038/s41388-020-01605-4] [PMID: 33452453]
[24]
Salvador, M.M.; Gómez de Cedrón, M.; Rubio, M.J.; Martínez, F.S.; Martínez, S.R.; Casado, E.; Ramírez de Molina, A.; Sereno, M. Lipid metabolism and lung cancer. Crit. Rev. Oncol. Hematol., 2017, 112, 31-40.
[http://dx.doi.org/10.1016/j.critrevonc.2017.02.001] [PMID: 28325263]
[25]
Luo, X.; Cheng, C.; Tan, Z.; Li, N.; Tang, M.; Yang, L.; Cao, Y. Emerging roles of lipid metabolism in cancer metastasis. Mol. Cancer, 2017, 16(1), 76.
[http://dx.doi.org/10.1186/s12943-017-0646-3] [PMID: 28399876]
[26]
Svensson, R.U.; Shaw, R.J. Lipid synthesis is a metabolic liability of non-small cell lung cancer. Cold Spring Harb. Symp. Quant. Biol., 2016, 81, 93-103.
[http://dx.doi.org/10.1101/sqb.2016.81.030874] [PMID: 28062532]
[27]
Yi, K.; Zhan, Q.; Wang, Q.; Tan, Y.; Fang, C.; Wang, Y.; Zhou, J.; Yang, C.; Li, Y.; Kang, C. PTRF/cavin-1 remodels phospholipid metabolism to promote tumor proliferation and suppress immune responses in glioblastoma by stabilizing cPLA2. Neuro-oncol., 2021, 23(3), 387-399.
[http://dx.doi.org/10.1093/neuonc/noaa255] [PMID: 33140095]
[28]
Moon, H.; Lee, C.S.; Inder, K.L.; Sharma, S.; Choi, E.; Black, D.M.; Lê Cao, K-A.; Winterford, C.; Coward, J.I.; Ling, M.T.; Craik, D.J.; Parton, R.G.; Russell, P.J.; Hill, M.M. PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer. Oncogene, 2014, 33(27), 3561-3570.
[http://dx.doi.org/10.1038/onc.2013.315] [PMID: 23934189]
[29]
Liu, L. Lessons from cavin-1 deficiency. Biochem. Soc. Trans., 2020, 48(1), 147-154.
[http://dx.doi.org/10.1042/BST20190380] [PMID: 31922193]
[30]
Nassar, Z.D.; Parat, M.O. Caveola-forming proteins and prostate cancer. Cancer Metastasis Rev., 2020, 39(2), 415-433.
[http://dx.doi.org/10.1007/s10555-020-09874-x] [PMID: 32358634]
[31]
Gámez-Pozo, A.; Sánchez-Navarro, I.; Calvo, E.; Agulló-Ortuño, M.T.; López-Vacas, R.; Díaz, E.; Camafeita, E.; Nistal, M.; Madero, R.; Espinosa, E.; López, J.A.; Vara, J.Á.F. PTRF/cavin-1 and MIF proteins are identified as non-small cell lung cancer biomarkers by label-free proteomics. PLoS One, 2012, 7(3), e33752.
[http://dx.doi.org/10.1371/journal.pone.0033752] [PMID: 22461895]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy