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Current Bioactive Compounds

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ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

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Review Article

Bioactive Compound Containing Hepatoprotective Activity

Author(s): Amarjeet Yadav, Nirbhay Narayan Tiwari, Shobhit Prakash Srivastava, Shivendra Mani Tripathi and Sudhanshu Mishra*

Volume 19, Issue 9, 2023

Published on: 15 May, 2023

Article ID: e110423215658 Pages: 8

DOI: 10.2174/1573407219666230411111304

Price: $65

Abstract

The liver is an essential organ that aids in the metabolism and elimination of xenobiotics from the body and dysfunction of the liver is a serious health issue that concerns physicians, pharmaceutical companies, and regulatory bodies. The effects of numerous hazardous substances, particularly antibiotics, chemotherapeutics, carbon tetrachloride (CCl4), thioacetamide (TAA), and microorganisms on liver cells have been extensively researched. Synthetic drugs used to treat liver abnormalities in this condition can also harm the liver in other ways. The bioactivation of medicines into chemically reactive metabolites, which can interact with cellular macromolecules like proteins, lipids, and nucleic acids, causing protein malfunction, lipid peroxidation, DNA damage, and oxidative stress, causes liver damage. Natural medications have proven to preserve normal and useful liver stats while causing fewer adverse effects. The use of medicinal plants in the treatment of liver disorders has a long history. This review article aims to gather information about prospective phytochemicals from medicinal plants that have been investigated in modern scientific hepatotoxicity models. During this review process, we concluded that some medicinal plants were showing potent effects against liver damage due to their ability to minimize oxidative stress and modulate the metabolic pathway responsible for liver damage.

Graphical Abstract

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