Login Register Cart 0
Generic placeholder image

Current Aging Science

Editor-in-Chief

ISSN (Print): 1874-6098
ISSN (Online): 1874-6128

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Editorial

Aging, Sleep and Sleepiness Self-Assessment, and the Underlying Drives for Sleep and Wake

Author(s): Arcady A. Putilov*

Volume 16, Issue 2, 2023

Published on: 03 January, 2023

Page: [85 - 88] Pages: 4

DOI: 10.2174/1874609816666221209151012

Price: $65

Abstract

In 2016, a mini-issue of Current Aging Science (CAS) entitled “Effects of Aging on Circadian and Sleep Timing” has been published to report the state of the art in the studies of the effects of aging on the circadian and sleep regulating processes. The emphasis has been given to the regulatory processes involved in age-specific problems with sleep timing, continuity, and duration. Such problems can serve as targets for novel treatments for geriatric and sleep disorders. In the following 6 years, some new findings provided further insight into the previously recognized age-specific problems and highlighted new questions of research on the relation of aging to the regulatory mechanisms underlying circadian rhythmicity, sleep, and sleepiness. The theoretic framework of one of the directions of this research regards the interaction between the competing drives for sleep and wake as one of the basic features of regulatory processes underlying circadian rhythms, including such rhythms as the sleep-wake cycle and the diurnal variation in alertnesssleepiness levels. Here, earlier and more recently highlighted questions of the research in this framework were briefly reviewed.

« Previous Next »
Graphical Abstract

[1]
Putilov A. Editorial (Mini-Thematic Issue: Effects of Aging on Circadian and Sleep Timing). Curr Aging Sci 2015; 9(1): 3-4.
[http://dx.doi.org/10.2174/187460980901151229124215] [PMID: 26758413]
[2]
Edgar DM, Dement WC, Fuller CA. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J Neurosci 1993; 13(3): 1065-79.
[http://dx.doi.org/10.1523/JNEUROSCI.13-03-01065.1993] [PMID: 8441003]
[3]
Dijk DJ, Czeisler CA. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neurosci 1995; 15(5): 3526-38.
[http://dx.doi.org/10.1523/JNEUROSCI.15-05-03526.1995] [PMID: 7751928]
[4]
Putilov AA, Donskaya OG, Verevkin EG. Can we feel like being neither alert nor sleepy? The electroencephalographic signature of this subjective sub-state of wake state yields an accurate measure of objective sleepiness level. Int J Psychophysiol 2019; 135: 33-43.
[http://dx.doi.org/10.1016/j.ijpsycho.2018.11.005] [PMID: 30468756]
[5]
Dorokhov VB, Taranov AO, Sakharov DS, et al. Linking stages of non-rapid eye movement sleep to the spectral EEG markers of the drives for sleep and wake. J Neurophysiol 2021; 126(6): 1991-2000.
[http://dx.doi.org/10.1152/jn.00364.2021] [PMID: 34817290]
[6]
Putilov A, Münch M, Cajochen C. Principal component structuring of the non-REM Sleep EEG spectrum in older adults yields age-related changes in the sleep and wake drives. Curr Aging Sci 2013; 6(3): 280-93.
[http://dx.doi.org/10.2174/187460980603140101203412] [PMID: 23855458]
[7]
Putilov AA, Donskaya OG. Evidence for age-associated disinhibition of the wake drive provided by scoring principal components of the resting EEG spectrum in sleep-provoking conditions. Chronobiol Int 2016; 33(8): 995-1008.
[http://dx.doi.org/10.1080/07420528.2016.1189431] [PMID: 27253971]
[8]
Putilov A. Age-associated advance of sleep times relative to the circadian phase of alertness-sleepiness rhythm: Can it be explained by changes in ratios between strengths of the underlying oscillatory processes? Curr Aging Sci 2015; 9(1): 44-56.
[http://dx.doi.org/10.2174/1874609809666151130220442] [PMID: 26632431]
[9]
Driscoll HC, Serody L, Patrick S, et al. Sleeping well, aging well: a descriptive and cross-sectional study of sleep in “successful agers” 75 and older. Am J Geriatr Psychiatry 2008; 16(1): 74-82.
[http://dx.doi.org/10.1097/JGP.0b013e3181557b69] [PMID: 18070833]
[10]
Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: Developing normative sleep values across the human lifespan. Sleep 2004; 27(7): 1255-73.
[http://dx.doi.org/10.1093/sleep/27.7.1255] [PMID: 15586779]
[11]
Vitiello MV, Larsen LH, Moe KE. Age-related sleep change. J Psychosom Res 2004; 56(5): 503-10.
[http://dx.doi.org/10.1016/S0022-3999(04)00023-6] [PMID: 15172206]
[12]
Åkerstedt T, Schwarz J, Gruber G, Lindberg E, Theorell-Haglöw J. The relation between polysomnography and subjective sleep and its dependence on age - poor sleep may become good sleep. J Sleep Res 2016; 25(5): 565-70.
[http://dx.doi.org/10.1111/jsr.12407] [PMID: 27122391]
[13]
Redline S, Kirchner HL, Quan SF, Gottlieb DJ, Kapur V, Newman A. The effects of age, sex, ethnicity, and sleep-disordered breathing on sleep architecture. Arch Intern Med 2004; 164(4): 406-18.
[http://dx.doi.org/10.1001/archinte.164.4.406] [PMID: 14980992]
[14]
Putilov AA. Age-related changes in the association of sleep satisfaction with sleep quality and sleep–wake pattern. Sleep Biol Rhythms 2018; 16(2): 169-75.
[15]
Zilli I, Ficca G, Salzarulo P. Factors involved in sleep satisfaction in the elderly. Sleep Med 2009; 10(2): 233-9.
[http://dx.doi.org/10.1016/j.sleep.2008.01.004] [PMID: 18387848]
[16]
Duffy JF, Willson HJ, Wang W, Czeisler CA. Healthy older adults better tolerate sleep deprivation than young adults. J Am Geriatr Soc 2009; 57(7): 1245-51.
[http://dx.doi.org/10.1111/j.1532-5415.2009.02303.x] [PMID: 19460089]
[17]
Zitting KM, Münch MY, Cain SW, et al. Young adults are more vulnerable to chronic sleep deficiency and recurrent circadian disruption than older adults. Sci Rep 2018; 8(1): 11052.
[http://dx.doi.org/10.1038/s41598-018-29358-x] [PMID: 30038272]
[18]
Putilov AA. Time course of a new spectral electroencephalographic marker of sleep homeostasis. Somnologie 2016; 20(2): 134-43.
[http://dx.doi.org/10.1007/s11818-016-0051-y]
[19]
Åkerstedt T, Gillberg M. Subjective and objective sleepiness in the active individual. Int J Neurosci 1990; 52(1-2): 29-37.
[http://dx.doi.org/10.3109/00207459008994241] [PMID: 2265922]
[20]
Putilov AA, Donskaya OG, Poluektov MG, Dorokhov VB. Age- and gender-associated differences in the sleepy brain’s electroencephalogram. Physiol Meas 2021; 42(4): 044005.
[http://dx.doi.org/10.1088/1361-6579/abcdf3] [PMID: 33238257]
[21]
Johns MW. A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep 1991; 14(6): 540-5.
[http://dx.doi.org/10.1093/sleep/14.6.540] [PMID: 1798888]
[22]
Dorokhov VB, Sveshnikov DS, Puchkova AN, et al. Differential relationship of two measures of sleepiness with the drives for sleep and wake. Sleep Breath 2021; 25(4): 2179-87.
[http://dx.doi.org/10.1007/s11325-020-02269-w] [PMID: 33404964]
[23]
Mehra R, Wang L, Andrews N, et al. Dissociation of objective and subjective daytime sleepiness and biomarkers of systemic inflammation in sleep-disordered breathing and systolic heart failure. J Clin Sleep Med 2017; 13(12): 1411-22.
[http://dx.doi.org/10.5664/jcsm.6836] [PMID: 29065958]
[24]
Trotti LM. Characterizing sleepiness: Are we drawing the right line in the sand? J Clin Sleep Med 2017; 13(12): 1369-70.
[http://dx.doi.org/10.5664/jcsm.6824] [PMID: 29151431]
[25]
Duffy JF, Dijk DJ, Klerman EB, Czeisler CA. Later endogenous circadian temperature nadir relative to an earlier wake time in older people. Am J Physiol 1998; 275(5 Pt 2): R1478-87.
[PMID: 9791064]
[26]
Axelsson J, Ingre M, Kecklund G, Lekander M, Wright KP Jr, Sundelin T. Sleepiness as motivation: A potential mechanism for how sleep deprivation affects behavior. Sleep 2020; 43(6): zsz291.
[http://dx.doi.org/10.1093/sleep/zsz291] [PMID: 31782961]
[27]
Shochat T, Santhi N, Herer P, Dijk DJ, Skeldon AC. Sleepiness is a signal to go to bed: data and model simulations. Sleep 2021; 44(10): zsab123.
[http://dx.doi.org/10.1093/sleep/zsab123] [PMID: 33991415]
[28]
Kent BA, Feldman HH, Nygaard HB. Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer’s disease. Prog Neurobiol 2021; 197: 101902.
[http://dx.doi.org/10.1016/j.pneurobio.2020.101902] [PMID: 32877742]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy