Login Register Cart 0
Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Case Report

Cerebellar Hemangioblastomas in a High-risk Pregnancy: A Case Report and Review of Literature

Author(s): Xue Wang, Yang Liu* and Da-Ping Song

Volume 19, Issue 6, 2023

Published on: 31 October, 2022

Article ID: e171022210070 Pages: 4

DOI: 10.2174/1573405619666221017114922

Price: $65

Abstract

Introduction: Hemangioblastomas are highly vascular benign tumors that may increase in size during pregnancy. The concurrence of cerebellar hemangioblastoma in high-risk pregnancy is extremely rare and the treatment in this situation can be challenged.

Case: Here, we report a case of a 30-year-old woman in the 33rd PW who had experienced a severe headache, dizziness, vomiting, and limb weakness. Cesarean section was performed in the 34th PW, followed by neurosurgery under multidisciplinary discussion.

Discussion: The pathological exam suggested hemangioblastomas. Finally, both the pregnancy and the fetus had a good outcome.

Conclusion: This case emphasizes that the timing of surgery should be determined according to the neurological symptoms of the pregnancy and the gestational age (GA) and condition of the fetus.

Graphical Abstract

[1]
Nail Ö, Asiyan KA, Mustafa FG. Recurrence of cystic part of cerebellar hemangioblastoma at early postoperative period and its spontaneous resolution: A pregnant patient with serial magnetic resonance imaging findings. J Neurol Sci 2012; 29(2): 385-92.
[2]
Ma X, Zhang G, Guo T, et al. Management and outcomes of pregnant patients with central nervous system hemangioblastoma. J Clin Neurosci 2018; 57: 126-30.
[http://dx.doi.org/10.1016/j.jocn.2018.08.009] [PMID: 30262382]
[3]
Laviv Y, Wang JL, Anderson MP, Kasper EM. Accelerated growth of hemangioblastoma in pregnancy: The role of proangiogenic factors and upregulation of hypoxia-inducible factor (HIF) in a non-oxygen-dependent pathway. Neurosurg Rev 2019; 42(2): 209-26.
[http://dx.doi.org/10.1007/s10143-017-0910-4] [PMID: 29027018]
[4]
Bhigjee AI, Naidoo K. Multiple cerebellar haemangioblastomas symptomatic during pregnancy. Br J Neurosurg 1998; 12(3): 281-4.
[http://dx.doi.org/10.1080/02688699845168] [PMID: 11013697]
[5]
Vaquero J, Martínez R. Progesterone receptor proteins in cerebellar hemangioblastoma. Surg Neurol 1984; 21(1): 99.
[http://dx.doi.org/10.1016/0090-3019(84)90421-X] [PMID: 6537790]
[6]
Wiestler OD, Wolf HK. [Revised WHO classification and new developments in diagnosis of central nervous system tumors Pathologe 1995; 16(4): 245-55.
[http://dx.doi.org/10.1007/s002920050098] [PMID: 7667206]
[7]
Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007; 114(2): 97-109.
[http://dx.doi.org/10.1007/s00401-007-0243-4] [PMID: 17618441]
[8]
Ahadi M, Zham H, Rakhshan A, et al. Hemangioblastoma of the Central Nervous System: A Case Series of Patients Surgically Treated at Shohada-e-Tajrish Hospital, Tehran, Iran during 2004-2014. Iran J Child Neurol 2019; 13(2): 163-9.
[http://dx.doi.org/10.1055/s-2004-817695] [PMID: 31037089]
[9]
Erdogan B, Sen O, Aydin MV, Bagis T, Bavbek M. Cerebellar hemangioblastoma in pregnancy. A case report. J Reprod Med 2002; 47(10): 864-6.
[http://dx.doi.org/10.1007/s10143-017-0910-4] [PMID: 12418073]
[10]
Nayak SB, Sumalatha S, Shetty SD. A rare additional lobe of cerebellum, projecting from its superior surface. Anat Cell Biol 2022; 55(3): 376-9.
[http://dx.doi.org/10.5115/acb.22.048] [PMID: 35692090]
[11]
Hellams SE, Cohen RJ, Young HF. Cerebellar hemangioblastomas and von Hippel-Lindau syndrome. Va Med 1981; 108(1): 42-5.
[http://dx.doi.org/10.1007/s00401-007-0243-4] [PMID: 7210854]
[12]
Nathan L, Satin AJ, Twickler DM. Cerebellar hemangioblastoma complicating pregnancy. A case report. J Reprod Med 1995; 40(9): 662-4.
[http://dx.doi.org/10.1016/j.jocn.2018.08.009] [PMID: 8576886]
[13]
Rehman T, Ali R, Yonas H. Cerebellar haemangioblastoma: Temporising treatment in a high risk pregnancy. BMJ Case Rep 2009; 2009(may21 1): bcr0120091413.
[http://dx.doi.org/10.1136/bcr.01.2009.1413] [PMID: 21687031]
[14]
Delisle MF, Valimohamed F, Money D, Douglas MJ. Central nervous system complications of von Hippel-Lindau disease and pregnancy; perinatal considerations: Case report and literature review. J Matern Fetal Med 2000; 9(4): 242-7.
[http://dx.doi.org/10.1002/1520-6661(200007/08)9:4<242:AID-MFM11>3.0.CO;2-5] [PMID: 11048837]
[15]
Kanaan I, Jallu A, Kanaan H. Management strategy for meningioma in pregnancy: A clinical study. Skull Base 2003; 13(4): 197-204.
[http://dx.doi.org/10.1055/s-2004-817695] [PMID: 15912178]
[16]
Isla A, Alvarez F, Gonzalez A, García-Grande A, Perez-Alvarez M, García-Blazquez M. Brain tumor and pregnancy. Obstet Gynecol 1987; 26(2): 157-64.
[http://dx.doi.org/10.1016/0028-2243(87)90051-7] [PMID: 3601276]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy