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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Review Article

An Insight View on the Role of Herbal Medicines in Infectious Diseases

Author(s): Smriti Parashar, Rupesh K. Gautam*, Rajat Goyal, Sanjay Sharma, Sumeet Gupta and Pooja Mittal

Volume 9, Issue 4, 2023

Published on: 03 November, 2022

Article ID: e061022209653 Pages: 12

DOI: 10.2174/2215083808666221006120944

Price: $65

Abstract

Nature always has enough spirit and resilience to transform our limited vision. Herbal medicines include products prepared from natural herbs which are employed to treat several diseases. In India, about 80% of drugs are of herbal origin. Nowadays, people are much more aware of the various side effects of synthetic drugs, which have molded their interest in herbal products and herbal remedies. In history, various infectious diseases or pandemic conditions have been treated or controlled with herbal medicines. Many herbal plants like Emblica officinalis (Euphorbiaceae), Withania somnifera (Solanaceae), Swertia chirata (Gentianaceae), Asparagus racemosus (Liliaceae), and Vinca rosea/Catharanthus roseus (Apocynaceae) have been reported to be of high medicinal values and preferred in the development of many newer drugs. The active component from plant extract is isolated, standardized, and undergoes safety trials for validation. Novel drug development from herbs is the amalgamation of practices of native systems of medicine and quite a lot of therapeutic experience of earlier generations. It is also believed that most herbal contents are safe, cheap, and easily available. Herbal drugs are useful in various diseased and pathogenic conditions like tuberculosis, cancer, diabetes, AIDS, jaundice, skin diseases, etc. Many countries with ancient cultures like India, Egypt, and America still use various herbal-based medications. Research for future herbal product development is increasing worldwide. Therefore, taking into consideration future perceptions of herbal remedies, this review deals with the present status and future exploration in the development of herbal drugs as modern beneficial agents for treating various infectious diseases and related pharmacological problems.

Graphical Abstract

[1]
Goyal R, Sharma A, Thakur VK, Ola M, Sharma PC. Green chemistry approaches towards the design and synthesis of anti-infective fluoroquinolone derivatives. Curr Res Green Sust Chem 2021; 4: 100044.
[http://dx.doi.org/10.1016/j.crgsc.2020.100044]
[2]
Firenzuoli F, Gori L. Herbal medicine today: Clinical and research issues. Evid Based Complement Alternat Med 2007; 4(S1): 37-40.
[http://dx.doi.org/10.1093/ecam/nem096] [PMID: 18227931]
[3]
Aboelsoud NH. Herbal medicine in ancient Egypt. J Med Plant Res 2010; 4(2): 082-6.
[4]
Sen S, Chakraborty R, De B. Challenges and opportunities in the advancement of herbal medicine: India’s position and role in a global context. J Herb Med 2011; 1(3-4): 67-75.
[http://dx.doi.org/10.1016/j.hermed.2011.11.001]
[5]
Wachtel-Galor S, Benzie IF. Herbal medicine 2011. 1
[6]
Wang W, Xu J, Fang H, Li Z, Li M. Advances and challenges in medicinal plant breeding. Plant Sci 2020; 298: 110573.
[http://dx.doi.org/10.1016/j.plantsci.2020.110573] [PMID: 32771174]
[7]
Garg V, Dhar VJ, Sharma A, Dutt R. Facts about standardization of herbal medicine: A review. J Chin Integr Med 2012; 10(10): 1077-83.
[http://dx.doi.org/10.3736/jcim20121002] [PMID: 23073189]
[8]
Tilburt J, Kaptchuk TJ. Herbal medicine research and global health: An ethical analysis. Bull World Health Organ 2008; 86(8): 594-9.
[http://dx.doi.org/10.2471/BLT.07.042820] [PMID: 18797616]
[9]
Li JWH, Vederas JC. Drug discovery and natural products: End of an era or an endless frontier? Science 2009; 325(5937): 161-5.
[http://dx.doi.org/10.1126/science.1168243] [PMID: 19589993]
[10]
Baharvand-Ahmadi B, Bahmani M, Naghdi N, Saki K, Baharvand A, Rafieian-Kopaei M. Medicinal plants used to treat infectious and non-infectious diseases of skin and skin appendages in city of Urmia, northwest Iran. Pharm Lett 2015; 7(11): 189-96.
[11]
Huntley A, Ernst E. Herbal medicines for asthma: A systematic review. Thorax 2000; 55(11): 925-9.
[http://dx.doi.org/10.1136/thorax.55.11.925] [PMID: 11050261]
[12]
Touiti N, Houssaini TS, Iken I, Benslimane A, Achour S. Prevalence of herbal medicine use among patients with kidney disease: A cross-sectional study from Morocco. Nephrol Ther 2020; 16(1): 43-9.
[http://dx.doi.org/10.1016/j.nephro.2019.01.007] [PMID: 31383617]
[13]
Soilemezi D, Leydon GM, Yan R, et al. Herbal medicine for acute bronchitis: A qualitative interview study of patients’ and health professionals’ views. Complement Ther Med 2020; 55: 102-613.
[http://dx.doi.org/10.1016/j.ctim.2020.102613] [PMID: 33221589]
[14]
Ang L, Lee HW, Kim A, Lee MS. Herbal medicine for the management of COVID-19 during the medical observation period: A review of guidelines. Integr Med Res 2020; 9(3): 100465.
[http://dx.doi.org/10.1016/j.imr.2020.100465] [PMID: 32691000]
[15]
Qais FA, Khan MS, Althubiani AS, Al-Ghamdi SB, Ahmad I. Understanding biochemical and molecular mechanism of complications of glycation and its management by herbal medicine. In: New Look to Phytomedicine. Academic Press 2019; pp. 331-66.
[http://dx.doi.org/10.1016/B978-0-12-814619-4.00013-6]
[16]
Li R, Zhang Q, Liu J, et al. Processing methods and mechanisms for alkaloid-rich Chinese herbal medicines: A review. J Integr Med 2021; 19(2): 89-103.
[http://dx.doi.org/10.1016/j.joim.2020.12.003] [PMID: 33349610]
[17]
Sahoo N, Manchikanti P, Dey S. Herbal drugs: Standards and regulation. Fitoterapia 2010; 81(6): 462-71.
[http://dx.doi.org/10.1016/j.fitote.2010.02.001] [PMID: 20156530]
[18]
Ortiz S, Lecsö-Bornet M, Bonnal C, et al. Bioguided identification of triterpenoids and neolignans as bioactive compounds from anti-infectious medicinal plants of the Taira Atacama’s community (Calama, Chile). J Ethnopharmacol 2019; 231: 217-29.
[http://dx.doi.org/10.1016/j.jep.2018.10.029] [PMID: 30412750]
[19]
Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: Executive summary of the GINA dissemination committee report. Allergy 2004; 59(5): 469-78.
[http://dx.doi.org/10.1111/j.1398-9995.2004.00526.x] [PMID: 15080825]
[20]
Braman SS. The global burden of asthma. Chest 2006; 130(S1): 4S-12S.
[http://dx.doi.org/10.1378/chest.130.1_suppl.4S] [PMID: 16840363]
[21]
Mintah SO, Asafo-Agyei T, Archer MA, et al. Medicinal plants for treatment of prevalent diseases. In: Perveen S, Al-Taweel A, Eds. Pharmacognosy-Medicinal Plants. London: IntechOpen 2019.
[22]
Rajagopal PL, Premaletha K, Sreejith KR, Chacko IA, Nimisha KV. A critical review on herbal management of asthma in Kannur district of Kerala state. WWJMRD 2016; 2(3): 48-52.
[23]
Rahman MA, Islam MS. Alpinia calcarata Roscoe: A potential phytopharmacological source of natural medicine. Pharmacogn Rev 2015; 9(17): 55-62.
[http://dx.doi.org/10.4103/0973-7847.156350] [PMID: 26009694]
[24]
Seo JW, Cho SC, Park SJ, et al. 1′-Acetoxychavicol acetate isolated from Alpinia galanga ameliorates ovalbumin-induced asthma in mice. PLoS One 2013; 8(2): e56447.
[http://dx.doi.org/10.1371/journal.pone.0056447] [PMID: 23451048]
[25]
Sarkar S, Zaidi S, Chaturvedi AK, Srivastava R, Dwivedi PK, Shukla R. Search for a herbal medicine: Anti-asthmatic activity of methanolic extract of Curcuma longa. J Pharmacogn Phytochem 2015; 3: 59-72.
[26]
Okyere I, Aheto DW, Aggrey-Fynn J. Pelagia research library. Eur J Exp Biol 2011; 1(2): 178-88.
[27]
Saxena P, Saxena P. In-vitro and in-vivo evaluation of anti asthmatic activity of rhizomes extract of Acorus calamus (Linn.) in Guinea Pigs. Res J Pharm Sci 2014; 3: 1-6.
[28]
WHO. World Malaria Report 2014. WHO. 2015. Available from: http://www.who.int/malaria/publications/world_malaria_report_2014/en/ (Accessed on: 2021 Jan 29).
[29]
Tabuti JRS. Herbal medicines used in the treatment of malaria in Budiope county, Uganda. J Ethnopharmacol 2008; 116(1): 33-42.
[http://dx.doi.org/10.1016/j.jep.2007.10.036] [PMID: 18054454]
[30]
Chiyaka C, Garira W, Dube S. Effects of treatment and drug resistance on the transmission dynamics of malaria in endemic areas. Theor Popul Biol 2009; 75(1): 14-29.
[http://dx.doi.org/10.1016/j.tpb.2008.10.002] [PMID: 19013477]
[31]
Zirihi GN, Mambu L, Guédé-Guina F, Bodo B, Grellier P. In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. J Ethnopharmacol 2005; 98(3): 281-5.
[http://dx.doi.org/10.1016/j.jep.2005.01.004] [PMID: 15814260]
[32]
El Tahir A, Satti GMH, Khalid SA. Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell. J Ethnopharmacol 1999; 64(3): 227-33.
[http://dx.doi.org/10.1016/S0378-8741(98)00129-9] [PMID: 10363837]
[33]
de Mesquita ML, Grellier P, Mambu L, de Paula JE, Espindola LS. In vitro antiplasmodial activity of Brazilian cerrado plants used as traditional remedies. J Ethnopharmacol 2007; 110(1): 165-70.
[http://dx.doi.org/10.1016/j.jep.2006.09.015] [PMID: 17097251]
[34]
Wright CW, Phillipson JD, Awe SO, et al. Antimalarial activity of cryptolepine and some other anhydronium bases. Phytother Res 1996; 10(4): 361-3.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199606)10:4<361:AID-PTR845>3.0.CO;2-N]
[35]
Bugyei KA, Boye GL, Addy ME. Clinical efficacy of a tea-bag formulation of Cryptolepis sanguinolenta root in the treatment of acute uncomplicated falciparum malaria. Ghana Med J 2010; 44(1): 3-9.
[PMID: 21326984]
[36]
Paulo A, Gomes ET, Steele J, Warhurst DC, Houghton PJ. Antiplasmodial activity of Cryptolepis sanguinolenta alkaloids from leaves and roots. Planta Med 2000; 66(1): 30-4.
[http://dx.doi.org/10.1055/s-2000-11106] [PMID: 10705730]
[37]
Gaire BP, Subedi L. Phytochemistry, pharmacology and medicinal properties of Phyllanthus emblica Linn. Chin J Integr Med 2014; 2014: 1-8.
[http://dx.doi.org/10.1007/s11655-014-1984-2] [PMID: 25491539]
[38]
Bagavan A, Rahuman AA, Kaushik NK, Sahal D. In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum. Parasitol Res 2011; 108(1): 15-22.
[http://dx.doi.org/10.1007/s00436-010-2034-4] [PMID: 20809417]
[39]
Krishnaveni M, Mirunalini S. Therapeutic potential of Phyllanthus emblica (amla): The ayurvedic wonder. J Basic Clin Physiol Pharmacol 2010; 21(1): 93-105.
[PMID: 20506691]
[40]
De Wet H, Nzama VN, Van Vuuren SF. Medicinal plants used for the treatment of sexually transmitted infections by lay people in northern Maputaland, KwaZulu–Natal Province, South Africa. S Afr J Bot 2012; 78: 12-20.
[http://dx.doi.org/10.1016/j.sajb.2011.04.002]
[41]
Vermani K, Garg S. Herbal medicines for sexually transmitted diseases and AIDS. J Ethnopharmacol 2002; 80(1): 49-66.
[http://dx.doi.org/10.1016/S0378-8741(02)00009-0] [PMID: 11891087]
[42]
Kambizi L, Afolayan AJ. An ethnobotanical study of plants used for the treatment of sexually transmitted diseases (njovhera) in Guruve District, Zimbabwe. J Ethnopharmacol 2001; 77(1): 5-9.
[http://dx.doi.org/10.1016/S0378-8741(01)00251-3] [PMID: 11483371]
[43]
Koch F. Book review: A field guide to wild flowers Kwazulu‐natal and eastern region. and mountain flowers. Zoosyst Evol 2005; 81(1): 3-109.
[44]
Makunga NP. Turning folklore into an ethnomedicinal catalogue Medicinal Plants of South Africa, BE. van Wyk, B. van Oudtshoorn and N. Gericke: Book review. S Afr J Sci 2009; 105(7): 250.
[45]
Ndubani P, Höjer B. Traditional healers and the treatment of sexually transmitted illnesses in rural Zambia. J Ethnopharmacol 1999; 67(1): 15-25.
[http://dx.doi.org/10.1016/S0378-8741(99)00075-6] [PMID: 10616956]
[46]
Mabogo DE. The ethnobotany of the Vhavenda 1990.
[47]
Arnold HJ, Gulumian M. Pharmacopoeia of traditional medicine in Venda. J Ethnopharmacol 1984; 12(1): 35-74.
[http://dx.doi.org/10.1016/0378-8741(84)90086-2] [PMID: 6521492]
[48]
WHO. Fact sheets on tuberculosis WHO 2020. Available from: http://www.who.int/tb/publications/factsheets/en/ (Accessed on: 2021 Jan 29).
[49]
Van Soolingen D, Hoogenboezem T, De Haas PEW, et al. A novel pathogenic taxon of the Mycobacterium tuberculosis complex, Canetti: Characterization of an exceptional isolate from Africa. Int J Syst Bacteriol 1997; 47(4): 1236-45.
[http://dx.doi.org/10.1099/00207713-47-4-1236] [PMID: 9336935]
[50]
Mann A, Amupitan JO, Oyewale AO, Okogun JI, Ibrahim K. An Ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria. J Phytomed Therap 2007; 12: 1-21.
[51]
Mann A, Amupitan JO, Oyewale AO, et al. Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr J Biotechnol 2008; 7(11): 1630-6.
[52]
Block E. Allium botany and cultivation, ancient and mdern. Garlic and other alliums: The lore and the science 2010; 1-3.
[53]
Tattelman E. Health effects of garlic. Am Fam Physician 2005; 72(1): 103-6.
[PMID: 16035690]
[54]
Sivakumar A, Jayaraman G. Anti-tuberculosis activity of commonly used medicinal plants of south India. J Med Plants Res 2011; 5(31): 6881-4.
[http://dx.doi.org/10.5897/JMPR11.1397]
[55]
Gupta R, Thakur B, Singh P, et al. Anti-tuberculosis activity of selected medicinal plants against multi-drug resistant Mycobacterium tuberculosis isolates. Indian J Med Res 2010; 131(6): 809-13.
[PMID: 20571171]
[56]
Fern K, Fern AMR. Useful tropical plants Available from: http://tropical.theferns.info/ (Accessed on: 2021 Jan 29).
[57]
Dawid-Pać R. Medicinal plants used in treatment of inflammatory skin diseases. Adv Dermatol Allergol 2013; 30(3): 170.
[http://dx.doi.org/10.5114/pdia.2013.35620]
[58]
Ikeda Y, Murakami A, Ohigashi H. Ursolic acid: An anti- and pro-inflammatory triterpenoid. Mol Nutr Food Res 2008; 52(1): 26-42.
[http://dx.doi.org/10.1002/mnfr.200700389] [PMID: 18203131]
[59]
E. K. Systemic inflammatory response mediators the importance in clinical practice and intensive care. Anest Inten Ter 2001; 3: 181-9.
[60]
Andrographidis H. WHO monographs on selected medicinal plants. Geneva: WHO 2002; pp. 12-24.
[61]
Choi SW, Son BW, Son YS, Park YI, Lee SK, Chung MH. The wound-healing effect of a glycoprotein fraction isolated from aloe vera. Br J Dermatol 2001; 145(4): 535-45.
[http://dx.doi.org/10.1046/j.1365-2133.2001.04410.x] [PMID: 11703278]
[62]
Femenia A, Sánchez ES, Simal S, Rosselló C. Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr Polym 1999; 39(2): 109-17.
[http://dx.doi.org/10.1016/S0144-8617(98)00163-5]
[63]
Choi S, Chung MH. A review on the relationship between Aloe vera components and their biologic effects. Semin Integr Med 2003; 1(1): 53-62.
[http://dx.doi.org/10.1016/S1543-1150(03)00005-X]
[64]
Jia Y, Zhao G, Jia J. Preliminary evaluation: The effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing. J Ethnopharmacol 2008; 120(2): 181-9.
[http://dx.doi.org/10.1016/j.jep.2008.08.008] [PMID: 18773950]
[65]
Blumenthal M, Goldberg A, Brinckmann J. Herbal medicine. Expanded commission E monographs. In: Integrative Medicine Communications Newton. 2000; pp. 78-83.
[66]
Aries MF, Vaissiere C, Fabre B, Charveron M, Gall Y. Avena rhealba inhibits arachidonic acid cascade, CPLA2 and COX expression in human keratinocytes. Interest in cutaneous inflammatory disorders. J Invest Dermatol 2003; 121.
[67]
Aries MF, Vaissiere C, Fabre B, Charveron M, Gall Y. Immunomodulatory activity of Avena rhealba: Interest in skin inflammatory disorders. J Investig Dermatol 1999; 113(3): 485.
[68]
HMPC. Assessment Report on Avena Sativa L. In: Herba and Avena Sativa L. Fructus 2008.
[69]
Monographs ES. European scientific cooperative on phytotherapy. United Kingdom: ESCOP 2003.
[70]
Vyas S, Agrawal RP, Solanki P, Trivedi P. Analgesic and anti-inflammatory activities of Trigonella foenum-graecum (seed) extract. Acta Pol Pharm 2008; 65(4): 473-6.
[PMID: 19051589]
[71]
European Scientific Cooperative on Phytotherapy. Millefolii Herba 2009.
[72]
Finkelstein RA. Cholera, Vibrio cholerae O1 and O139, and other pathogenic vibrios. (4th ed.), Medical Microbiology 1996.
[73]
Acharyya S, Patra A, Bag PK. Evaluation of the antimicrobial activity of some medicinal plants against enteric bacteria with particular reference to multi-drug resistant Vibrio cholerae. Trop J Pharm Res 2009; 8(3): 231-7.
[http://dx.doi.org/10.4314/tjpr.v8i3.44538]
[74]
Sánchez E, García S, Heredia N. Extracts of edible and medicinal plants damage membranes of Vibrio cholerae. Appl Environ Microbiol 2010; 76(20): 6888-94.
[http://dx.doi.org/10.1128/AEM.03052-09] [PMID: 20802077]
[75]
Mackenzie JS, Smith DW. COVID-19: A novel zoonotic disease caused by a coronavirus from China: What we know and what we don’t. Microbiol Aust 2020; 41(1): 45.
[http://dx.doi.org/10.1071/MA20013] [PMID: 32226946]
[76]
Ding Y, Zeng L, Li R, et al. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function. BMC Complement Altern Med 2017; 17(1): 130.
[http://dx.doi.org/10.1186/s12906-017-1585-7] [PMID: 28235408]
[77]
Benarba B, Pandiella A. Medicinal plants as sources of active molecules against COVID-19. Front Pharmacol 2020; 11: 1189.
[http://dx.doi.org/10.3389/fphar.2020.01189] [PMID: 32848790]

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