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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Case Report

Cryptosporidiosis in Yellow Nail Syndrome – A Rare Case Report

Author(s): Aditya Kundu, Saumya Srivastava, Vibhor Tak* and Jagdish Prasad Goyal

Volume 23, Issue 2, 2023

Published on: 21 October, 2022

Article ID: e200922208989 Pages: 3

DOI: 10.2174/1871526522666220920142423

Price: $65

Abstract

Background: Cryptosporidium species infection causes malabsorption and severe diarrhea in immunocompromised hosts. Association of Yellow Nail Syndrome (YNS) and Cryptosporidiosis is rare and has not been reported till date. Immunity can also be affected in this case of YNS is associated with autoimmune disorders.

Case Presentation: Here, we describe a case of persistent diarrhea in an 8 month old YNS patient. Modified Ziehl-Neelsen staining and Saffranine-Methylene blue revealed oocyts of Cryptosporidium species. Following appropriate treatment, the patient’s symptoms improved and the patient was discharged in a hemodynamically stable condition.

Discussion: Cryptosporidiosis is a significant cause of morbidity and mortality in immunocompromised patients. YNS per se as well as treatment including steroids leads to immunosuppression in individuals making them susceptible host for opportunistic infections like Cryptosporidiosis.

Conclusion: Clinicians should be aware of the condition and screen for Cryptosporidiosis in any immunocompromised patients with diarrheal symptoms, as parasitic infection like this are opportunistic in them.

Keywords: Cryptosporidium, yellow nail syndrome, modified ziehl neelsen, saffranine-methylene blue, cryptosporidiosis, opportunistic infections

Graphical Abstract

[1]
Nime FA, Burek JD, Page DL, Holscher MA, Yardley JH. Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology 1976; 70(4): 592-8.
[http://dx.doi.org/10.1016/S0016-5085(76)80503-3] [PMID: 815126]
[2]
Cama VA, Bern C, Roberts J, et al. Cryptosporidium species and subtypes and clinical manifestations in children, Peru. Emerg Infect Dis 2008; 14(10): 1567-74.
[http://dx.doi.org/10.3201/eid1410.071273] [PMID: 18826821]
[3]
Kotloff KL, Blackwelder WC, Nasrin D, et al. The Global Enteric Multicenter Study (GEMS) of diarrheal disease in infants and young chil-dren in developing countries: Epidemiologic and clinical methods of the case/control study. Clinical infectious diseases 2012; 55 (Suppl. 4): S232-45.
[4]
Ajjampur SSR, Muliyil J, Ward H, et al. Symptomatic and asymptomatic Cryptosporidium infections in children in a semi-urban slum community in southern India. Am J Trop Med Hyg 2010; 83(5): 1110-5.
[http://dx.doi.org/10.4269/ajtmh.2010.09-0644] [PMID: 21036847]
[5]
Clode PL, Koh WH, Thompson RCA. Life without a host cell: What is Cryptosporidium? Trends Parasitol 2015; 31(12): 614-24.
[http://dx.doi.org/10.1016/j.pt.2015.08.005] [PMID: 26440789]
[6]
Kaushik K, Khurana S, Wanchu A, Malla N. Evaluation of staining techniques, antigen detection and nested PCR for the diagnosis of cryptosporidiosis in HIV seropositive and seronegative patients. Acta Trop 2008; 107(1): 1-7.
[http://dx.doi.org/10.1016/j.actatropica.2008.02.007] [PMID: 18479668]
[7]
Gupta S, Samra D, Yel L, Agrawal S. T and B cell deficiency associated with yellow nail syndrome Scand J Immunol 2012; 75(3): 329-35.
[http://dx.doi.org/10.1111/j.1365-3083.2011.02653.x] [PMID: 21995335]
[8]
Agnamey P, Djeddi D, Diallo A, et al. Childhood cryptosporidiosis: A case report. J Parasitol Res 2010; 2010: 935625.
[http://dx.doi.org/10.1155/2010/935625] [PMID: 20936160]
[9]
Maldonado F, Tazelaar HD, Wang CW, Ryu JH. Yellow nail syndrome: Analysis of 41 consecutive patients. Chest 2008; 134(2): 375-81.
[http://dx.doi.org/10.1378/chest.08-0137] [PMID: 18403655]
[10]
Emerson PA. Yellow nails, lymphoedema, and pleural effusions. Thorax 1966; 21(3): 247-53.
[http://dx.doi.org/10.1136/thx.21.3.247] [PMID: 5914998]
[11]
Hiller E, Rosenow EC III, Olsen AM. Pulmonary manifestations of the yellow nail syndrome. Chest 1972; 61(5): 452-8.
[http://dx.doi.org/10.1378/chest.61.5.452] [PMID: 5046843]
[12]
Abell E, Samman PD. Yellow nail syndrome treated by intralesional triamcinolone acetonide. Br J Dermatol 1973; 88(2): 200-1.
[PMID: 4706464]
[13]
Imadojemu S, Rubin A. Dramatic improvement of yellow nail syndrome with a combination of intralesional triamcinolone, fluconazole, and sinusitis management. Int J Dermatol 2015; 54(11): e497-9.
[http://dx.doi.org/10.1111/ijd.12916] [PMID: 26226835]
[14]
Williams HC, Buffham R, du Vivier A. Successful use of topical vitamin E solution in the treatment of nail changes in yellow nail syn-drome. Arch Dermatol 1991; 127(7): 1023-8.
[http://dx.doi.org/10.1001/archderm.1991.01680060097012] [PMID: 2064401]

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